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Advanced pharmaceutics : physicochemical principles

Author: Cherng-ju Kim
Publisher: Boca Raton, Fla. : CRC Press, ©2004.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:

Discussing a comprehensive range of topics, this book reviews various aspects of physical pharmacy. It explains the basic, mechanistic, and quantitative interpretation skills needed to solve physical  Read more...

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Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Cherng-ju Kim
ISBN: 0849317290 9780849317293
OCLC Number: 53231840
Notes: Includes index.
Description: 498 pages : illustrations ; 24 cm
Contents: Thermodynamics --
Ideal Gases --
Real Gases --
Thermodynamics --
The First Law of Thermodynamics --
Enthalpy (Heat Content) and Heat Capacity --
Thermochemistry --
Heat Engine and the Carnot Cycle --
The Second Law of Thermodynamics and Entropy --
The Third Law of Thermodynamics --
Free Energy --
Free Energy Functions --
Fundamental Equations of Thermodynamics and Their Uses --
Free Energy of Formation and Standard Free Energy Change --
Free Energy and Chemical Equilibrium --
The Thermodynamics of Mixing --
Ionic Equilibrium --
Strong Acids and Strong Bases --
pH of the Solution of a Strong Acid or Strong Base --
Titration Curve of a Strong Base with a Strong Acid --
Monoprotic Weak Acids and Weak Bases --
pH of the Solution of a Monoprotic Weak Acid or Weak Base --
Titration Curve of a Weak Acid with a Strong Base --
pH of the Solution of Salts of Weak Acids or Weak Bases --
pH of the Solution of a Mixture of Conjugate Acids and Bases: Henderson-Hasselbalch Equation --
Buffer Solutions and Buffer Capacity --
Effect of Ionic Strength on Buffers --
Solubility of Weak Electrolytes and Ampholytes --
Polyprotic Weak Acids and Weak Bases --
pH of the Solution of a Diprotic Weak Acid, Weak Base, or Ampholyte --
pH of the Solution of a Triprotic Weak Acid, Weak Base, or Polyprotic Amino Acid --
Titration Curves of a Polyprotic Weak Acid, Weak Base, or Polyampholyte --
Buffer Capacity of a Buffer Solution Containing a Polyprotic Weak Acid or Weak Base and Its Conjugate Base or Acid --
Sparingly Soluble Salts. Solubility Product Constant and Solubility of Sparingly Soluble Salts --
Solubility of Sparingly Soluble Salts of Weak Acids or Weak Bases --
Effect of Ionic Strength on Solubility of Sparingly Soluble Salts --
Solutions and Distribution --
Solutions of Solids and Nonvolatile Liquids in Liquids --
Ideal Solutions --
Nonideal Solutions and the Solubility Parameter --
Intermolecular and Intramolecular Interactions between Molecules --
Prediction of Solubility --
Solubilization of Weak Acids or Weak Bases in Cosolvent Systems --
Dissolution Kinetics of Solids in Liquids --
Solutions of Volatile Liquids in Liquids --
Raoult's Law --
Two-Component Liquid Systems --
Three-Component Liquid Systems --
Solutions of Gases in Liquids (Henry's Law) --
Colligative Properties --
Freezing Point Depression and Boiling Point Elevation --
Osmotic Pressure --
Vapor Pressure Lowering --
Isotonic Solutions --
Freezing Point Method --
NaCl Equivalent Method --
Distribution Law (Partition Coefficient) --
Nondissociated and Nonassociated Systems --
Association of a Solute in One Phase --
Dissociation in Aqueous Phase and Association in Oil Phase --
Distribution and Solubilization of Weak Acids or Weak Bases in Micelles and the Aqueous Phase --
Distribution and Solubilization of Drug Chemicals by Inclusion Complex Formation --
Distribution of Drugs in Proteins (Protein Binding) --
Surface Chemistry and Colloids --
Adsorption from Solutions --
Adsorption Processes --
Adsorption Isotherms --
Langmuir Isotherm --
Freundlich Isotherm --
BET Isotherm. Competitive Adsorption --
Factors Affecting Adsorption --
Nature of the Adsorbent --
Nature of the Adsorbate --
pH --
Temperature --
Liquid-Liquid Systems (Emulsions) --
Liquid-Liquid Interfacial Tension --
Adsorption of Surfactants at Interfaces --
Surfactants and Theory of Emulsification --
Surface-Active Materials --
Naturally Occurring and Semisynthetic Materials --
Finely Divided Solids --
Type of Emulsion and HLB System --
Instability of Emulsions --
Micellization and Solubilization --
Microemulsions --
Solid-Liquid Systems (Suspensions) --
Wetting and Wetting Agents --
Surfactants --
Hydrocolloids --
Solvents --
Electrical Double Layer and Stabilization of Colloidal Particles --
The Electric Double Layer --
The Stabilization and Destabilization of Colloid Systems --
Sedimentation of Dilute Suspensions --
Prevention of Cake Formation --
Kinetics --
Pathways of Drug Degradation --
Hydrolysis --
Oxidation --
Photolysis --
Single and Multiple Reactions, Elementary Reactions, Molecularity, and Order of Reactions --
Irreversible Reactions --
Zero-Order Reactions --
First-Order Reactions --
Apparent Zero-Order Reactions --
Second-Order Reactions --
Determination of the Order of Reaction and Its Rate Constant --
Differentiation Method --
Integration Method --
Other Irreversible Reactions --
Autocatalytic Reactions --
Parallel Reactions --
Consecutive Reactions --
Reversible Reactions --
Reversible First-Order Reactions --
Reversible Second-Order Reactions --
Reversible and Series Reactions (Eigenvalue Method). Use of Laplace Transform for Differential Rate Equations --
Definitions and Properties --
Applications of Laplace Transforms for Drug Degradation and Biotransformation --
Enzyme-Substrate Reactions --
Enzyme-Substrate Reactions without Inhibition --
Enzyme-Substrate Reaction with Inhibition --
Acid-Base Catalyzed Degradation Kinetics --
Acid-Base Catalyzed Hydrolysis of Neutral Chemicals --
Acid-Base Catalyzed Hydrolysis of Polyprotic Weak Acids and Weak Bases --
Oxidation (Free Radical Reaction) --
Degradation Kinetics in Inclusion Complexes, Micelles, and Liposomes --
Temperature Effects on the Reaction Rate Constants --
Diffusion --
Transport Processes --
Diffusion Coefficients --
Diffusion through a Membrane --
Unsteady-State Diffusion through a Membrane --
Steady-State Diffusion through a Membrane --
Constant Activity Reservoir Systems --
Nonconstant Activity Reservoir Systems --
Multilayer Membrane Devices --
Diffusion in a Monolithic Matrix --
Dissolved Drug in Polymeric Drug Carriers --
Dispersed Drug in Polymeric Drug Carriers --
Diffusion in a Membrane-Matrix System --
Diffusion during the Swelling of a Matrix --
Diffusion in Matrix Erosion/Degradation --
Homogeneous Erosion/Degradation --
Heterogeneous Erosion/Degradation --
Diffusion in a Matrix Swelling/Erosion --
Diffusion with Chemical Reaction in a Membrane --
Surface Area and Concentration Gradient Systems --
Osmotically Controlled Systems --
Polymer Science --
Classification of Polymers --
Molecular Weight and Molecular Weight Distribution of Polymers. Characterization of Polymers --
Viscosity Method --
Osmometry --
Light Scattering --
Size Exclusion Chromatography (SEC) --
Effective Linear Calibration Method without Peak Broadening Correction --
Effective Linear Calibration Method with Peak Broadening Correction --
Universal Calibration Method --
Multiple Detector System (e.g., Concentration and Light-Scattering Detectors) --
Polymer Synthesis --
Addition Homo-Polymerization (Free-Radical Homo-Polymerization) --
Polyvinylpyrrolidone (PVP) and Its Copolymers --
Polyvinylacetate and Its Derivatives --
Polyvinylchloride (PVC) --
Polyisobutylene (PIB) --
Free-Radical Copolymerization --
Eudragit and Kollicoat Series --
Ion Exchange Resins --
Carbopol or Carbomer --
Poly(ethylene-co-vinyl acetate) (PEVAc) --
Poly(vinyl alcohol-grafted-ethylene glycol) (Kollicoat, IR) --
Step Polymerization (Condensation Polymerization) --
Acid-Catalyzed Esterification Polymerization of A-A and B-B --
Self-Catalyzed Condensation Polymerization --
Molecular Weight Control --
Polyanhydrides --
Poly(orthoesters) --
Poly(amino acids) --
Silicone Polymers --
Ring-Opening Polymerization --
Polylactic Acid, Polyglycolic Acid, and Polycaprolactone --
Polyethylene Glycol (PEG), Polyethylene Oxide (PEO), and Block Copolymers of Ethylene Oxide and Propylene Oxide (PEOPO) --
Polyphosphazene (PPP) --
Natural Polymers and Their Modification --
Cellulose --
Cellulose Derivatives --
Chitosan --
Polysaccharides --
Gelatin.
Responsibility: Cherng-Ju Kim.
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"The book contains 22 chapters and covers a very wide range of topics. With a few exceptions, these contributions are from leaders in the field of drug delivery. The ideas and results presented are Read more...

 
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