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Advanced purchase commitments for a malaria vaccine : estimating costs and effectiveness

Author: Ernst R Berndt; National Bureau of Economic Research.
Publisher: Cambridge, Mass. : National Bureau of Economic Research, 2005.
Series: Working paper series (National Bureau of Economic Research), no. 11288.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
"To overcome the problem of insufficient research and development (R & D) on vaccines for diseases concentrated in low-income countries, sponsors could commit to purchase viable vaccines if and when they are developed. One or more sponsors would commit to a minimum price that would be paid per person immunized for an eligible product, up to a certain number of individuals immunized. For additional purchases, the  Read more...
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Details

Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Ernst R Berndt; National Bureau of Economic Research.
OCLC Number: 60035295
Notes: April 2005.
Title from first page of PDF document.
Description: 1 online resource (29 pages) : illustrations.
Series Title: Working paper series (National Bureau of Economic Research), no. 11288.
Responsibility: Ernst R. Berndt [and others].

Abstract:

"To overcome the problem of insufficient research and development (R & D) on vaccines for diseases concentrated in low-income countries, sponsors could commit to purchase viable vaccines if and when they are developed. One or more sponsors would commit to a minimum price that would be paid per person immunized for an eligible product, up to a certain number of individuals immunized. For additional purchases, the price would eventually drop to short-run marginal cost. If no suitable product were developed, no payments would be made. We estimate the offer size which would make the revenues from R & D investments on a malaria vaccine similar to revenues realized from investments in typical existing commercial pharmaceutical products, as well as the degree to which various contract models and assumptions would affect the cost-effectiveness of such a commitment for the case of a malaria vaccine. Under conservative assumptions, we document that the intervention would be highly cost-effective from a public health perspective. Sensitivity analyses suggest most characteristics of a hypothetical malaria vaccine would have little effect on the cost-effectiveness, but that the duration of protection against malaria conferred by a vaccine strongly affects potential cost-effectiveness. Readers can conduct their own sensitivity analyses employing a web-based spreadsheet tool"--National Bureau of Economic Research web site.

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