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Advances in Bioactivation Research
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Advances in Bioactivation Research

Author: Adnan Elfarra
Publisher: New York, NY : Springer New York, 2008.
Series: Pharmaceutical Aspects.
Edition/Format:   Book : English : 1. EdView all editions and formats
Summary:

Provides researchers with information on bioactivation reactions of drugs and toxicants. This title contains examples of how molecular and genomic biology, proteomics, mass spectrometry, and  Read more...

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Document Type: Book
All Authors / Contributors: Adnan Elfarra
ISBN: 0387772995 ) 9780387772998 (Gb. (Pr. in Vorb.)
OCLC Number: 254296382
Description: 60 schw.-w. Ill ; 235 mm x 155 mm.
Contents: General Concepts and Basic Mechanisms.- Metabolic Concerns in Drug Design.- Role of Bioactivation in Idiosyncratic Drug Toxicity.- Michael Addition-Elimination Reactions.- Induction of Drug Metabolizing Enzymes.- Mechanism-Based Inactivation of Cytochrome P450 2A and 2B Enzymes.- CYP2E1-Biochemical and Toxicological Aspects and Role in Alcohol-Induced Liver Injury.- One and Two Electron Mediated Reduction of Quinones.- Lipoxidation-Derived Electrophiles as Biological Reactive Intermediates.- Bioactivation and Protein Modification Reactions of Unsaturated Aldehydes.- TISSUE-Specific Features And Risk Assessment Applications.- Adaptive Responses and Signal Transduction Pathways in Chemically Induced Mitochondrial Dysfunction and Cell Death.- Hepatic Bioactivation and Drug-Induced Liver Injury.- Role of Cysteine S-Conjugate ss-Lyases in the Bioactivation of Renal Toxicants.- Bioactivation of Xenobiotics in Lung: Role of CYPs and FMOs.- Generation of Reactive Metabolites and Associated DNA Adducts from Benzene, Butadiene, and Polycyclic Aromatic Hydrocarbons in Bone Marrow.- Butadiene-Mediated Mutagenesis and Carcinogenesis.- Pharmacogenetics of Drug Bioactivation Pathways.- Human Phenanthrene Metabolites as Probes for the Metabolic Activation and Detoxification of Carcinogenic Polycyclic Aromatic Hydrocarbons.
Series Title: Pharmaceutical Aspects.
Responsibility: Hrsg. Adnan Elfarra.

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