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Advances in biology and therapy of multiple myeloma. Volume 1, Basic science

Author: Nikhil C Munshi; Kenneth C Anderson
Publisher: New York ; London : Springer, 2012.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Despite the advances in conventional, and novel agent and high dose chemotherapy, multiple myeloma remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in multiple myeloma focusing on the development of molecularly-based novel targeted single-agent and combination  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Advances in biology and therapy of multiple myeloma. Volume 1, Basic science.
New York ; London : Springer, 2012
(OCoLC)817270588
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Nikhil C Munshi; Kenneth C Anderson
ISBN: 9781461446668 146144666X
OCLC Number: 819588275
Description: 1 online resource
Contents: Part 1. Myeloma Molecular Pathways and Cell Signaling --
Genomic Strategies Determining Progression from MGUS to Multiple Myeloma / Esteban Braggio and Rafael Fonseca --
Prognostic Implication of Genetic Changes (Cytogenetics, and FISH, Gains and Losses of DNA by SNP Array and aCGH) in Risk Stratification in Myeloma / Jill Corre and Hervé Avet-Loiseau --
Advances in Multiple Myeloma Gene-Expression Profiling / Saad Usmani, B. Barlogie and J.D. Shaughnessy Jr. --
Growth Factors in Multiple Myeloma / Jérôme Moreaux, Caroline Bret, Karène Mahtouk, Anne-Catherine Sprynski and Dirk Hose, et al. --
Role of Wnt Signaling Pathways in Multiple Myeloma Pathogenesis / Mariateresa Fulciniti and Daniel R. Carrasco --
The mTOR Pathway in Multiple Myeloma / Joseph Gera and Alan Lichtenstein --
Jak/STAT Signaling in the Pathogenesis and Treatment of Multiple Myeloma / Erik A. Nelson, Sarah R. Walker and David A. Frank. Part 2. Myeloma Microenvironment --
The Bone Marrow Microenvironment: Novel Targets to Circumvent Minimal Residual Disease and Drug Resistance in Multiple Myeloma / Kenneth H. Shain and William S. Dalton --
Osteoclasts: Potential Target for Blocking Microenvironmental Support of Myeloma / Deborah L. Galson, Sonia D'Souza and G. David Roodman --
Targeting the BAFF/APRIL Cytokine Network in Multiple Myeloma / Stephen A. Mihalcik and Diane F. Jelinek --
Role of Osteoblast in Myeloma Pathology / Sonia Vallet and Noopur Raje --
Migration and Homing in Multiple Myeloma / Giada Bianchi and Irene M. Ghobrial --
Genes and Proteins of Myeloma Endothelial Cells to Search Specific Targets of the Tumor Vasculature / Domenico Ribatti and Angelo Vacca --
Epigenetic Regulation of Myeloma Within Its Bone Marrow Microenvironment / Elke De Bruyne, Ken Maes, Sarah Deleu, Els Van Valckenborgh and Eline Menu, et al. --
Targeting Multiple Myeloma Tumor Angiogenesis: Focus on VEGF / Klaus Podar and Kenneth C. Anderson --
Novel In Vivo Models in Myeloma / Eric Sanchez, Haiming Chen and James R. Berenson.₉
Other Titles: Basic science
Responsibility: edited by Nikhil C. Munshi, Kenneth C. Anderson.

Abstract:

Multiple myeloma remains incurable, immune to developments in cancer treatment such as high-dose chemotherapy and new kinds of agents. This volume assesses new approaches currently being developed  Read more...

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