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Advances in DNA Repair in Cancer Therapy

Author: Lawrence Panasci; Raquel Aloyz; Moulay Alaoui-Jamali
Publisher: New York, NY : Springer New York : Imprint: Springer, 2013.
Series: Cancer Drug Discovery and Development, 72; Cancer drug discovery and development, 72.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
This book deals with the emerging role of various DNA repair proteins and the regulatory elements which are implicated in cancer therapy such as DNA cross-linking agents, radiotherapy and bleomycin. The DNA repair genes discussed include those involved in BRCA/Rad51-related homologous recombinational repair, DNA-PK related nonhomologous endjoining and the nucleotide excision repair gene, ERCC1. Moreover, the role  Read more...
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Additional Physical Format: Printed edition:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Lawrence Panasci; Raquel Aloyz; Moulay Alaoui-Jamali
ISBN: 9781461447412 1461447410 9781461447405 1461447402
OCLC Number: 841812634
Description: 1 online resource (VIII, 312 p. 35 illus., 25 illus. in color.)
Contents: Preface --
Repair of DNA Interstrand Cross-links Produced by Cancer Chemotherapeutic Drugs --
DNA-PK, a pharmacological target in cancer chemotherapy and radiotherapy? --
Growth factor receptor signaling, DNA damage response, and cancer cell susceptibility to chemotherapy and relapses --
The relationship between DNA-repair genes, cellular radiosensitivity and the response of tumors and normal tissues to radiotherapy --
Important Roles of ERCC1 in DNA Repair and Targeted Therapy --
The role of BRCA1 and BRCA2 in anticancer drug therapy --
DNA-PK in CLL Chemotherapy --
Poly(ADP) ribose polymerase at the interface of DNA damage signalling and DNA repair --
Cellular protection against the antitumor drug bleomycin --
ATR as a Therapeutic Target --
Telomeres, Telomerase and DNA Damage Response in Cancer Therapy --
RAD51 is a key protein of DNA repair and homologous recombination in humans --
Index. ỹ
Series Title: Cancer Drug Discovery and Development, 72; Cancer drug discovery and development, 72.
Responsibility: edited by Lawrence Panasci, Raquel Aloyz, Moulay Alaoui-Jamali.

Abstract:

This book details the biological mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. It also reviews the impact of such novel inhibitors of DNA  Read more...

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