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Advances in DNA Repair in Cancer Therapy

Author: Lawrence Panasci; Raquel Aloyz; Moulay Alaoui-Jamali
Publisher: New York, NY : Springer New York : Imprint: Springer, 2013.
Series: Cancer Drug Discovery and Development, 72.
Edition/Format:   Print book : Document   Computer File : EnglishView all editions and formats
Database:WorldCat
Summary:

This book details the biological mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. It also reviews the impact of such novel inhibitors of DNA  Read more...

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Additional Physical Format: Printed edition:
Advances in DNA Repair in Cancer Therapy
Material Type: Document
Document Type: Book, Computer File
All Authors / Contributors: Lawrence Panasci; Raquel Aloyz; Moulay Alaoui-Jamali
ISBN: 9781461447412 1461447410
OCLC Number: 939853324
Description: 1 online resource (VIII, 312 p. 35 illus., 25 illus. in color.)
Contents: Preface.- Repair of DNA Interstrand Cross-links Produced by Cancer Chemotherapeutic Drugs.- DNA-PK, a pharmacological target in cancer chemotherapy and radiotherapy?.- Growth factor receptor signaling, DNA damage response, and cancer cell susceptibility to chemotherapy and relapses.- The relationship between DNA-repair genes, cellular radiosensitivity and the response of tumors and normal tissues to radiotherapy.- Important Roles of ERCC1 in DNA Repair and Targeted Therapy.- The role of BRCA1 and BRCA2 in anticancer drug therapy.- DNA-PK in CLL Chemotherapy.- Poly(ADP) ribose polymerase at the interface of DNA damage signalling and DNA repair.- Cellular protection against the antitumor drug bleomycin.- ATR as a Therapeutic Target.- Telomeres, Telomerase and DNA Damage Response in Cancer Therapy.- RAD51 is a key protein of DNA repair and homologous recombination in humans.- Index.
Series Title: Cancer Drug Discovery and Development, 72.
Responsibility: edited by Lawrence Panasci, Raquel Aloyz, Moulay Alaoui-Jamali.
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