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Advances in immunology. Volume 133

Author: Frederick W Alt
Publisher: Cambridge, MA : Academic Press is an imprint of Elsevier, 2017.
Series: Advances in immunology, v. 133.
Edition/Format:   eBook : Document : English : First edition
Summary:
Advances in Immunology, a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
(OCoLC)957680867
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Frederick W Alt
ISBN: 9780128124109 0128124105
OCLC Number: 973396803
Description: 1 online resource.
Contents: Front Cover; Advances in Immunology; Copyright; Contents; Contributors; Chapter One: Macrophages and Mitochondria: A Critical Interplay Between Metabolism, Signaling, and the Functional Activity; 1. Introduction; 2. Mitochondrial Metabolism Governs Macrophage Activation State; 2.1. Metabolic Reprogramming in Proinflammatory Macrophages; 2.2. Metabolic Profile in IL-4-Activated Macrophages; 3. Mitochondrial ROS in Innate Immune Responses; 3.1. mROS Are Crucial Components of Inflammatory Signaling Pathways; 3.2. TLR Signaling Upregulates mROS Production 3.3.3. Recruiting AID Activity to the lg Locus Is a Team Effort 3.3.4. Contribution of RNA Processing to AID Targeting; 3.4. Phosphorylation Focuses AID Activity to the Ig Locus; 4. AID Initiates a DNA Repair Cascade; 4.1. Detecting Uracil; 4.2. The UNG and Base Excision Repair Arm; 4.3. The MutSa-Initiated Arm; 4.4. Interactions Between BER and MMR During Antibody Diversification; 4.5. DNA Nicks and Breaks; 4.6. Repairing the Breaks; 5. Postdeamination Roles of AID; 6. Perspectives; Acknowledgments; References 4. Mitochondrial-Mediated Antiviral Immunity4.1. RIG-I-Like Receptors; 4.2. Mitochondrial Antiviral Signaling; 4.3. Proteins That Regulate MAVS Signaling; 4.4. Mitochondrial Dynamics Regulate Antiviral Immunity; 4.5. ROS Regulation of Antiviral Signaling; 5. Inflammasome Activation and Mitochondria; 5.1. The Mitochondrion Is a Scaffold for Inflammasome Activation; 5.2. Mitochondrial Signals in Inflammasome Activation; 5.3. Mitophagy Restrains Inflammasome Activation; 6. Concluding Remarks; Acknowledgments; References Chapter Two: Molecular Mechanisms of Somatic Hypermutation and Class Switch Recombination1. Antibody Diversification During the Humoral Response; 2. Molecular Mechanisms of SHM and CSR; 2.1. Overview; 2.2. Relevance for Humoral Immunity; 3. DNA Deamination at the Igs; 3.1. Activation-Induced Deaminase; 3.2. Molecular Regulation of AID Activity; 3.2.1. Biochemical Activity of AID; 3.2.2. Limiting the Levels of AID in the Nucleus; 3.3. Targeting AID to the Ig Loci; 3.3.1. AID Piggybacks on Transcription to Access the DNA; 3.3.2. The Ig Loci Contribute to AID Activity Chapter Three: Emerging Major Histocompatibility Complex Class I-Related Functions of NLRC51. Background; 2. Lessons From CIITA; 2.1. CIITA: The Master Transcriptional Regulator of MHC Class II Genes; 2.2. Transcriptional Regulation of CIITA; 2.3. Transcriptional Regulation by CIITA; 2.4. Transcriptional Targets of CIITA; 3. NLRC5 and Its Role in Regulating MHC Class I Levels; 3.1. Complex Transcriptional Regulation of MHC Class I Genes; 3.2. NLRC5: A Transcriptional Regulator of MHC Class I Genes; 3.3. NLRC5 vs CIITA: Similarities and Differences
Series Title: Advances in immunology, v. 133.
Other Titles: Advances in immunology.
Responsibility: edited by Frederick W. Alt.

Abstract:

Advances in Immunology, a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

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