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Advances in immunology. / Volume 56

Author: Frank J Dixon
Publisher: San Diego ; New York ; Boston : Academic Press, ©1994.
Series: Advances in immunology.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
A Leader in Immunology.
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Genre/Form: Electronic books
Periodicals
Additional Physical Format: Print version:
Advances in immunology. Volume 56.
San Diego ; New York ; Boston : Academic Press, ©1994
(OCoLC)31138506
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Frank J Dixon
ISBN: 9780080578323 0080578322 0120224569 9780120224562
OCLC Number: 298976013
Description: 1 online resource (viii, 501 pages) : illustrations.
Contents: Front Cover; Advances in Immunology, Volume 56; Copyright Page; Contents; Chapter 1. Properties and Functions of Interleukin-10; I. Introduction; II. Discovery; III. Physical Properties; IV. cDNA Cloning; V. Gene Structure; VI. Production; VII. Biological Effects of ILl0; VIII. Two Herpesviruses Have Acquired an ILl0 Gene; IX. Functional Similarities between ILl0 and Other TH2 Cytokines; X. Expression of ILl0 Correlates with TH2 Responses; XI. Effects of in Vivo Manipulation of ILl0 Levels; XII. ILl0 in Pregnancy; XIII. The ILl0 Receptor; XIV. Conclusions; References. Chapter 2. The Mechanism of V(D)J Joining: Lessons from Molecular, Immunological, and Comparative AnalysesI. Introduction; II. V(D)J Joining Basics; III. The Endogenous Substrate; IV. Model Systems; V. Fine-Structure of Recombinants: Clues to the Mechanism; VI. Agents of Joining; VII. The Origins of Order in V(D)J Joining; VIII. Fidelity and Pathogenesis; IX. The Joining Mechanism: A Working Hypothesis; X. Conclusion; Appendix; References; Chapter 3. Involvement of the Protein Tyrosine Kinase p56lck in T Cell Signaling and Thymocyte Development; I. Introduction. II. Regulation of lck ExpressionIII. Regulation of p56lck; IV. Signal Transduction via p56lck; V. Participation of p56lck in T Cell Signaling; VI. Involvement of p56lck in the Control of Thymocyte Development; VII. Future Directions; References; Chapter 4. Generating the Antibody Repertoire in Rabbit; I. Introduction; II. B Lymphocyte Development; III. Ig Genes and Gene Rearrangements; IV. Development of the Antibody Repertoire; V. GALT and the Antibody Repertoire; VI. Summary; References; Chapter 5. Immunotherapeutic Strategies Directed at the Trimolecular Complex; I. Introduction. II. Target 1: The T CellIII. Target 2: The Peptide Antigen; IV. Target 3: The MHC (la) Molecule; V. Conclusion; References; Chapter 6. Therapeutic Regulation of the Complement System in Acute Injury States; I. Introduction; II. An Overview of Complement Activation; III. Clinical Assessment of Complement Activation; IV. Intrinsic Regulation of Complement Activation; V. Interactions between Leukocytes and Complement; VI. Complement Deficiency States; VII. Clinical Injury and Acute Complement Activation (Failures of Intrinsic Regulation?); VIII. Therapeutic Complement Inhibition Using sCRl. IX. Therapeutic Complement Inhibition Using Other AgentsX. Summary; References; Chapter 7. Chemoimmunoconjugates for the Treatment of Cancer; I. Introduction: Concept of Targeted Chemotherapy; II. Monoclonal Antibodies as Carriers; III. Conjugation Chemistry; IV. Drug-Monoclonal Antibody Conjugates; V. Mode of Action of Drug-Monoclonal Antibody Conjugates; VI. Barriers to Antibody-Targeted Chemotherapy; VII. Clinical Trials; VIII. Conclusion; References; Chapter 8. The Molecular Basis of Susceptibility to Rheumatoid Arthritis; I. Overview; II. Objectives.
Series Title: Advances in immunology.
Responsibility: edited by Frank J. Dixon.

Abstract:

Part of a serial publication that presents developments in immunology, with a focus on cellular and molecular biology, and virology. This issue includes articles on the functions and properties of  Read more...

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