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Advances in immunology

Author: Frederick W Alt
Publisher: Waltham, MA : Elsevier, 2016.
Series: Advances in immunology, vol. 129.
Edition/Format:   eBook : Document : English : First editionView all editions and formats
Summary:
Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Frederick W Alt
ISBN: 0128052155 9780128052150 9780128047989 0128047984
OCLC Number: 934769884
Description: 1 online resource : illustrations.
Contents: Front Cover; Advances in Immunology; Copyright; Contents; Contributors; Chapter One: Context- and Tissue-Specific Regulation of Immunity and Tolerance by Regulatory T Cells; 1. Introduction; 2. Origins of Treg Cells: ``The Third Function of the Thymus (Seddon & Mason, 2000);́́ 3. Suppressive Properties of Treg Cells; 3.1. Suppression of DC Maturation and Function; 3.2. Suppression via Cytolysis; 3.3. Suppression via Metabolic Disruption; 3.4. Suppression Through Secretion of Cytokines; 4. Murine Tissue-Specific Treg Cells; 4.1. Lung-Resident Treg Cells; 4.2. Intestinal Treg Cells. 4.3. Visceral Adipose Tissue Treg Cells4.4. Treg Cells in Skeletal Muscle; 4.5. Treg Cells in the Skin; 5. Human Tissue-Resident Treg Cells; 6. Conclusions; References; Chapter Two: Endogenous Retroelements and the Host Innate Immune Sensors; 1. Introduction; 2. Toll-Like Receptors; 3. RIG-I and MDA5; 4. Protein Kinase R; 5. Inflammasome; 6. Conclusion and Perspectives; References; Chapter Three: B-Lymphopoiesis in Fetal Liver, Guided by Chemokines; 1. Introduction; 2. Lineage Choice Between Myeloid and Lymphoid Development; 3. Cytokine Receptor Expressions on Early Progenitors in Fetal Liver. 4. Changes of Transcription Factor Expressions and of Hematopoietic Differentiation Capacities During Myeloid/Lymphoid Pr ... 5. B-Cell Development from Early Fetal Liver Progenitors; 6. Nonhematopoietic Mesenchymal Stromal Cells, but not Endothelial Cells, Produce Myeloid-Inducing CSF-1 and Lymphoid-Ind ... ; 7. Selective Chemokines Produced by Endothelium or Mesenchyme Guide Migration of Single Progenitors Expressing Several Ch ... ; 8. Outlook; Acknowledgments; References; Chapter Four: The Roles of the Secreted Phospholipase A2 Gene Family in Immunology; 1. General Aspects of sPLA2s. 2. Potential Roles of sPLA2s: Lessons from sPLA2 Transgenic Mice3. Group IIA sPLA2 (PLA2G2A); 3.1. Antibacterial Defense; 3.2. Inflammation; 3.3. Cancer; 3.4. Atherosclerosis; 4. Group IID sPLA2 (PLA2G2D); 4.1. Contact Hypersensitivity; 4.2. Viral Infection; 5. Group IIF sPLA2 (PLA2G2F); 5.1. Psoriasis; 5.2. Skin Cancer; 6. Group III sPLA2 (PLA2G3); 6.1. Anaphylaxis; 6.2. Other Potential Functions; 7. Group V sPLA2 (PLA2G5); 7.1. Macrophage Phagocytosis; 7.2. Th2 Immunity; 7.3. Metabolic Diseases; 7.4. Cardiovascular Diseases; 8. Group X sPLA2 (PLA2G10); 8.1. Asthma and Airway Inflammation. 8.2. Colitis8.3. Cardiovascular Diseases, Metabolic Syndrome, and Beyond; 9. Other sPLA2s and sPLA2 Receptor (PLA2R1); 9.1. Other sPLA2s; 9.2. PLA2R1; 10. Perspectives; Acknowledgments; References; Chapter Five: Pleiotropic Roles of Type 1 Interferons in Antiviral Immune Responses; 1. Type 1 Interferon Signaling During Acute Viral Infection; 1.1. Suppressing Viral Replication/Dissemination; 1.2. Promote Antiviral Immune Responses; 1.3. Augment Pathological Immune Responses; 2. Type I Interferon Signaling and Persistent/Chronic Viral Infection; 2.1. Controlling Virus Replication/Dissemination.
Series Title: Advances in immunology, vol. 129.
Responsibility: edited by Frederick Alt.

Abstract:

Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

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