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Advances in medicinal chemistry. Volume 4

Author: B E Maryanoff; A B Reitz
Publisher: Stamford, Conn. : Jai Press, 1999.
Series: Advances in Medicinal Chemistry.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop,  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Maryanoff, B.E.
Advances in Medicinal Chemistry.
Burlington : Elsevier, ©1999
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: B E Maryanoff; A B Reitz
ISBN: 9780080526379 0080526373
OCLC Number: 234381572
Notes: Title from PDF title page (viewed July 22, 2008).
Description: 1 online resource.
Contents: Front Cover; Advances in Medicinal Chemistry; Copyright Page; CONTENTS; LIST OF CONTRIBUTORS; PREFACE; CHAPTER 1. NOVEL PEPTIDE MIMETIC BUILDING BLOCKS AND STRATEGIES FOR EFFICIENT LEAD FINDING; CHAPTER 2. RECENT ADVANCES IN THE MEDICINAL CHEMISTRY OF TAXOID ANTICANCER AGENTS; CHAPTER 3. SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF PEROXIDIC ANTIMALARIALS BASED ON ARTEMISININ; CHAPTER 4. DESIGN OF COMPOUND LIBRARIES FOR DETECTING AND PURSUING NOVEL SMALL MOLECULE LEADS. CHAPTER 5. A THEORETICAL MODEL OF THE HUMAN THROMBIN RECEPTOR (PAR-1), THE FIRST KNOWN PROTEASE-ACTIVATED G-PROTEIN-COUPLED RECEPTORCHAPTER 6. FARNESYL TRANSFERASE INHIBITORS: DESIGN OF A NEW CLASS OF CANCER CHEMOTHERAPEUTIC AGENTS; INDEX.
Series Title: Advances in Medicinal Chemistry.
Responsibility: editors, Bruce E. Maryanoff, Allen B. Reitz.

Abstract:

Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer dr.

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