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E-mail Message: I thought you might be interested in this item at http://www.worldcat.org/oclc/437596708 Title: Advances in molecular toxicology. / Vol. 1 Author: James C Fishbein Publisher: Amsterdam ; Oxford, UK : Elsevier, 2006. ISBN/ISSN: 6610707995 9786610707997 0080465382 9780080465388 OCLC:437596708

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Advances in molecular toxicology. / Vol. 1

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Advances in molecular toxicology. / Vol. 1

Author:	James C Fishbein
Publisher:	Amsterdam ; Oxford, UK : Elsevier, 2006.
Edition/Format:	eBook : Document : English
Rating:	(not yet rated) 0 with reviews - Be the first.

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Genre/Form:	Electronic books
Material Type:	Document, Internet resource
Document Type:	Internet Resource, Computer File
All Authors / Contributors:	James C Fishbein Find more information about:
ISBN:	6610707995 9786610707997 0080465382 9780080465388
OCLC Number:	437596708
Notes:	Title from e-book title screen (viewed Oct. 15, 2007).
Description:	1 online resource : ill.
Contents:	Cover -- Contents -- Contributors -- Editor's Preface -- Bioactivation of Estrogens to Toxic Quinones -- Introduction -- Mechanisms of Estrogen Carcinogenesis -- Oxidation of Catechol Estrogens to O-Quinones -- DNA Damage Induced by Catechol Estrogens -- Protein Damage Induced by Catechol Estrogens -- Role of the Estrogen Receptor in Estrogen Carcinogenesis -- Substitution of the 4-Hydroxy group on Catechol Estrogens with Fluorine Abolishes Quinoid Formation while Maintaining Estrogenic Activity -- Summary -- Acknowledgment -- References -- Diverse Mechanisms of Endogenous Nucleobase Deamination in DNA and RNA -- Introduction -- Simple Hydrolytic Mechanisms -- Nitrosative Deamination and Inflammation -- Enzymatic Deamination of Nucleobases -- Purine Metabolism as a Source of Nucleobase Deamination in DNA and RNA -- Repair and Mutagenesis of Nucleobase Deamination Products -- Summary -- Acknowledgments -- References -- Site-Specific Modification of the Electrophile Sensor Protein Keap1 and Activation of Nrf2-Dependent Gene Expression -- Introduction -- Patterns of Keap1 Modification by Electrophiles -- Relationship of Keap1 Modification Sites and Functionally Significant Cysteine Residues -- Electrophile-Induced Ubiquitination of Keap1 -- Unresolved Questions about Electrophile-Induced Activation of NRF2 -- Acknowledgments -- References -- Genotoxicity of Chlorophenols and Ochratoxin A -- Introduction -- Chlorophenols -- Ochratoxin A -- Acknowledgments -- References -- Idiosyncratic Drug Reactions: Clinical Evidence for Mechanistic Hypotheses -- Background -- Postulated Mechanisms -- Summary and Conclusions -- Acknowledgments -- References -- Subject Index -- Last Page.
Responsibility:	edited by James C. Fishbein.

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