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Aging of the genome : the dual role of DNA in life and death

Author: Jan Vijg
Publisher: Oxford ; New York : Oxford University Press, 2007.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Aging has long been ascribed to the gradual accumulation of mutations in the genome. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. This book reviews the concept of genomic instability as a possible universal cause of aging in complex organisms resulting from recent advances in functional genomics and systems biology. -  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Vijg, Jan.
Aging of the genome.
Oxford ; New York : Oxford University Press, 2007
(DLC) 2006039672
(OCoLC)76864399
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Jan Vijg
ISBN: 9780191524585 0191524581
OCLC Number: 137237241
Description: 1 online resource (x, 372 pages) : illustrations
Contents: The logic of aging --
Genome structure and function --
Genome maintenance --
Genome instability and accerated aging --
The aging genome --
From genome to phenome --
A genomic limit to life?
Responsibility: Jan Vijg.
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Abstract:

Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. This book reviews the concept of genomic instability as a possible universal cause of  Read more...

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'The book represents a substantial effort and documents the broad and deep insight that Vijg has into the field of aging. It should greatly stimulate interest and the entry of promising new Read more...

 
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