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Alzheimer's disease and frontotemporal dementia : methods and protocols

Author: Erik D Roberson
Publisher: Totowa, N.J. : Humana ; London : Springer [distributor], 2011.
Series: Methods in molecular biology (Clifton, N.J.), 670.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:

Alzheimer's disease and frontotemporal dementia, two of the most prevalent neurodegenerative diseases, are dreaded disorders that attack the neural networks underlying memory and personality, systems  Read more...

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Genre/Form: Electronic books
Additional Physical Format: Print version:
Alzheimer's disease and frontotemporal dementia.
Totowa, N.J. : Humana ; London : Springer [distributor], 2011
(OCoLC)659242931
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Erik D Roberson
ISBN: 9781607617440 1607617447
OCLC Number: 680490600
Description: 1 online resource (x, 277 pages) : illustrations.
Contents: Contemporary approaches to Alzheimer's disease and frontotemporal dementia / E.D. Roberson --
Preparing synthetic A[beta] in different aggregation states / W.B. Stine [and others] --
Isolation of low-N amyloid [beta]-protein oligomers from cultured cells, CSF, and brain / G.M. Shankar [and others] --
Detecting A[beta]*56 oligomers in brain tissues / M.A. Sherman and S.E. Lesne --
Assessing A[beta] aggregation state by atomic force microscopy / J. Legleiter --
Measuring APP carboxy-terminal fragments / L.A. Esposito --
Detection of APP intracellular domain in brain tissue / S.W. Pimplikar and A. Suryanarayana --
Cell-based assays for regulators of tau biology / U.K. Jinwal and C.A. Dickey --
Split GFP complementation assay for quantitative measurement of tau aggregation in situ / W. Chun, G.S. Waldo and G.V. Johnson --
Apolipoprotein E expression and purification / Y. Newhouse and K.H. Weisgraber --
A[beta] toxicity in primary cultured neurons / A. Ferreira [and others] --
Manipulation of gene expression in the central nervous system with lentiviral vectors / B. Sun and L. Gan --
Selecting a mouse model of Alzheimer's disease / J. Chin --
Monitoring spatial learning and memory in Alzheimer's disease mouse models using the Morris Water Maze / K. Scearce-Levie --
Step-by-step in situ hybridization method for localizing gene expression changes in the brain / J.J. Palop, E.D. Roberson and I. Cobos --
Real-time visualization of axonal transport in neurons / Y. Osakada and B. Cui --
Quantifying biomarkers of cognitive dysfunction and neuronal network hyperexcitability in mouse models of Alzheimer's disease: Depletion of calcium-dependent proteins and inhibitory hippocampal remodeling / J.J. Palop, L. Mucke and E.D. Roberson --
Epigenetic changes in the brain: Measuring global histone modifications / G. Rumbaugh and C.A. Miller.
Series Title: Methods in molecular biology (Clifton, N.J.), 670.
Responsibility: edited by Erik D. Roberson.

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From the reviews:"This book brings together research authorities in the field of Alzheimer's disease (AD) and frontotemporal dementia (FTD) to share their laboratory methods and protocols for Read more...

 
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