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Alzheimer's Disease: Lessons from Cell Biology

Author: K S Kosik; D J Selkoe; Y Christen
Publisher: Berlin, Heidelberg : Springer Berlin Heidelberg, 1995.
Series: Research and Perspectives in Alzheimer's Disease, Fondation Ipsen.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
This book brings together recent developments in Alzheimer's disease research with related discoveries in the field of cell biology. The book moves between basic cell biological concepts that form the underpinnings of modern Alzheimer's disease research, and current findings about proteins and cellular processes affected by the disease. Divided into three topics, the book addresses (1) protein trafficking, a problem  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: K S Kosik; D J Selkoe; Y Christen
ISBN: 9783642794230 3642794238
OCLC Number: 851370983
Description: 1 online resource (xix, 243 pages 60 illustrations, 1 illustration in color.).
Contents: Endocytotic Pathways in Neurons --
Mechanisms of Molecular Sorting in Polarized Cells: Relevance to Alzheimer’s Disease --
Regulation of Receptor Trafficking by ras-Like GTPases --
Alzheimer’s Disease and Hemorrhagic Stroke: Their Relationship to ?A4 Amyloid Deposition --
Combining In Vitro Cell Biology and In Vivo Mouse Modelling to Study the Mechanisms Underlying Alzheimer’s Disease --
Implication of the Amyloid Precursor Protein in Neurite Outgrowth --
Physiological Production and Polarized Secretion of the Amyloid ?-Peptide in Epithelial Cells: A Route to the Mechanism of Alzheimer’s Disease --
Regulation and Structure of the MAP Kinases ERK1 and ERK2 --
Calcineurin as a Pivotal Ca2+-Sensitive Switching Element in Biological Responses: Implications for the Regulation of Tau Phosphorylation in Alzheimer’s Disease --
Phosphorylation of Tau and Its Relationship with Alzheimer Paired Helical Filaments --
Posttranslational Modifications of the Tau in PHF: Phosphorylation and Ubiquitination --
Tau Variants in Aging and Neurodegenerative Disorders --
A Phosphorylated Tau Species Is Transiently Present in Developing Cortical Neurons and Is Not Associated with Stable Microtubules --
Modifications of Phosphorylated Tau Immunoreactivity Linked to Excitotoxicity in Neuronal Cultures --
Neurofilaments and Motor Neuron Disease --
Lurcher, Cell Death and the Cell Cycle --
Neuronal Death, Proinflammatory Cytokines and Amyloid Precursor Protein: Studies on Staggerer Mutant Mice --
Amyloid ?-Peptide Induces Necrotic Cell Death in PC12 Cells --
Linking Amyloid Precursor Protein Processing and Tau-Related Pathology in Alzheimer’s Disease.
Series Title: Research and Perspectives in Alzheimer's Disease, Fondation Ipsen.
Responsibility: edited by K.S. Kosik, D.J. Selkoe, Y. Christen.

Abstract:

Like the unflinching gaze of Captain Ahab walking the deck of the Pequod, Alzheimer researchers have had their sights fixed firmly on the disease for many years. Perhaps for most of the years since  Read more...

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