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Alzheimer's disease : methods and protocols

Author: N M Hooper; Humana Press.
Publisher: Totowa, N.J. : Humana Press, ©2000.
Series: Methods in molecular medicine, 32.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
With the molecular mechanisms underlying the various forms of muscular dystrophy now rapidly clarifying, precise diagnosis has become a reality, and even a requirement in clinical practice. In Muscular Dystrophy: Methods and Protocols, Katherine Bushby and Louise Anderson have assembled an outstanding collection of key techniques for the analysis of DNA and protein from patients suspected to suffer from muscular  Read more...
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Genre/Form: Electronic books
Laboratory manuals
Manuels de laboratoire
Additional Physical Format: Alzheimer's disease
(DLC) 99017627
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: N M Hooper; Humana Press.
ISBN: 0585395071 9780585395074 1280821558 9781280821554 9786610821556 6610821550
OCLC Number: 49851558
Language Note: English.
Notes: Source of title; title from Title page.
Reproduction Notes: Electronic reproduction. [S.l.] : HathiTrust Digital Library, 2010. MiAaHDL
Description: 1 online resource (xiv, 408 pages) : illustrations.
Details: Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.
Contents: Introduction to Alzheimer's disease / D. Allsop-The genetics of Alzheimer's disease / N. Brindle and P.S. George-Hyslop-Advances in methodology and current prospects for primary drug therapies for Alzheimer's disease / D.S. Knopman-Production and functional assays of recombinant secreted amyloid precursor protein (app) (sappalpha) / S.W. Barger-Quantifying abeta(1-40) and abeta (1-42) using sandwich-elisa / D.M. Skovronsky [and others]-Electrophoretic separation and immunoblotting of abeta(1-40) and abeta (1-42) / M. Staufenbiel and P.A. Paganetti-Abeta-induced proinflammatory cytokine release from differentiated human thp-1 monocytes / K.R. Brunden [and others]-Effects of the beta-amyloid peptide on membrane ion permeability / H.A. Pearson-Analysis of beta-amyloid peptide degradation in vitro / B. Cordell and A. Naidu-Posttranslational modifications of amyloid precursor protein : Ectodomain phosphorylation and sulfation / J. Walter and C. Haass-Posttranslational modifications of the amyloid precursor protein : Glycosylation / C. Liu [and others]-Using an amyloid precursor protein (app) reporter to characterize alpha-secretase / S.B. Roberts-Inhibition of alpha-secretase by zinc metalloproteinase inhibitors / S. Parvathy, A.J. Turner and N.M. Hooper-Development of neoepitope antibodies against the beta-secretase cleavage site in the amyloid precursor protein / C.W. Gray and E.H. Karran-Beta-secretase : Tissue culture studies of sequence specificity, inhibitors, and candidate enzymes / M. Citron-Using beta-secretase inhibitors to distiguish the generation of the abeta peptides terminating at val-40 and ala-42 / P.A. Paganetti and M. Staufenbiel-Designing animal models of Alzheimer's disease with amyloid precursor protein (app) transgenes / J.F. Loring-Phosphorylation of amyloid precursor protein (app) family proteins / T. Suzuki [and others]-Determining the transmembrane topology of the presenilins / G. Thinakaran and A. Doan-Normal proteolytic processing of the presenilins / H. Hartmann and B.A. Yankner-Apoptotic proteolytic cleavage of the presenilins by caspases / T.W. Kim-The phosphorylation of presenilin proteins / J. Walter-Interaction of the presenilins with the amyloid precursor protein (APP) / A. Weidemann [and others]-Distribution of presenilins and amyloid precursor protein (APP) in detergent-insoluble membrane domains / E.T. Parkin, A.J. Turner and N.M. Hooper-Characterization and use of monoclonal antibodies to tau and paired helical filament tau / P. Davies-Tau phosphorylation both in vitro and in cells / C.H. Reynolds, G.M. Gibb and S. Lovestone-Transglutaminase-catalyzed formation of Alzheimer-like insoluble complexes from recombinant tau / B.J. Balin and D.M. Appelt.
Series Title: Methods in molecular medicine, 32.
Other Titles: Biomedprotocols.
Responsibility: edited by Nigel M. Hooper.

Abstract:

The aim of Alzheimer's Disease: Methods and Protocols is to bring together the main biochemical, cell biological, and molecular biological techniques and approaches that are being used to investigate  Read more...

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"...this volume contains well-written chapters containing factual insights and useful clarifications. An example is David Allsop's introduction of the field through the orthodox views of the amyloid Read more...

 
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<http://experiment.worldcat.org/entity/work/data/795200648#Topic/protein_precursors> # Protein Precursors
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    schema:name "Protein Precursors"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/795200648#Topic/proteinase_inhibitory_proteins_secretory> # Proteinase Inhibitory Proteins, Secretory
    a schema:Intangible ;
    schema:name "Proteinase Inhibitory Proteins, Secretory"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/795200648#Topic/psychiatric_disorders_individual> # Psychiatric Disorders, Individual
    a schema:Intangible ;
    schema:name "Psychiatric Disorders, Individual"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/795200648#Topic/psychiatry_and_psychology> # Psychiatry and Psychology
    a schema:Intangible ;
    schema:name "Psychiatry and Psychology"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/795200648#Topic/wetenschappelijke_technieken> # Wetenschappelijke technieken
    a schema:Intangible ;
    schema:name "Wetenschappelijke technieken"@en ;
    .

<http://id.loc.gov/authorities/subjects/sh2009114748> # Alzheimer's disease--Diagnosis
    a schema:Intangible ;
    schema:name "Alzheimer's disease--Diagnosis"@en ;
    .

<http://id.loc.gov/authorities/subjects/sh93001015> # Molecular diagnosis
    a schema:Intangible ;
    schema:name "Molecular diagnosis"@en ;
    .

<http://qut.eblib.com.au/patron/FullRecord.aspx?p=3037003>
    rdfs:comment "Connect to e-book on ProQuest Ebook Central" ;
    .

<http://viaf.org/viaf/135368212> # Humana Press.
    a schema:Organization ;
    schema:name "Humana Press." ;
    .

<http://viaf.org/viaf/84090966> # N. M. Hooper
    a schema:Person ;
    schema:familyName "Hooper" ;
    schema:givenName "N. M." ;
    schema:name "N. M. Hooper" ;
    .

<http://worldcat.org/entity/work/data/795200648#CreativeWork/alzheimer_s_disease>
    a schema:CreativeWork ;
    rdfs:label "Alzheimer's disease" ;
    schema:isSimilarTo <http://www.worldcat.org/oclc/49851558> ; # Alzheimer's disease : methods and protocols
    .

<http://worldcat.org/isbn/9780585395074>
    a schema:ProductModel ;
    schema:isbn "0585395071" ;
    schema:isbn "9780585395074" ;
    .

<http://worldcat.org/isbn/9781280821554>
    a schema:ProductModel ;
    schema:isbn "1280821558" ;
    schema:isbn "9781280821554" ;
    .

<http://worldcat.org/isbn/9786610821556>
    a schema:ProductModel ;
    schema:isbn "6610821550" ;
    schema:isbn "9786610821556" ;
    .

<https://0-link-springer-com.pugwash.lib.warwick.ac.uk/book/10.1385/1592591957>
    rdfs:comment "Connect to Springer Protocols e-book" ;
    .


Content-negotiable representations

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