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Aminoglycoside antibiotics : from chemical biology to drug discovery

Author: D P Arya
Publisher: Hoboken, N.J. : Wiley-Interscience, ©2007.
Series: Wiley series in drug discovery and development.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:

Advances that open new avenues in developing aminoglycoside antibiotics During the last twenty years, there have been numerous advances in the understanding of the chemistry, biochemistry, and  Read more...

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Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: D P Arya
ISBN: 9780471743026 047174302X
OCLC Number: 144525705
Description: x, 319 pages, [8] pages of plates : illustrations (some color) ; 25 cm.
Contents: Preface. Contributors. 1. In the Beginning There Was Streptomycin (Julian Davies). 2. The Biochemistry and Genetics of Aminoglycoside Producers (Wolfgang Piepersberg, Khaled M. Aboshanab, Heike Schmidt-Beisner, and Udo F. Wehmeier). 3. Mechanisms of Aminoglycoside Antibiotic Resistance (Tushar Shakya and Gerard D. Wright). 4. Design, Chemical Synthesis, and Antibacterial Activity of Kanamycin and Neomycin Class Aminoglycoside Antibiotics (Jinhua Wang and Cheng-Wei Tom Chang). 5. NMR Structural Studies of Aminoglycoside: RNA Interaction (R. Andrew Marshall and Joseph D. Puglisi). 6. Structural Comparisons Between Prokaryotic and Eukaryotic Ribosomal Decoding A Sites Free and Complexed with Aminoglycosides (Jiro Kondo and Eric Westhof). 7. Binding of Antibiotics to the Aminoacyl-tRNA Site of Bacterial Ribosome (Dale Kling, Christine Chow, and Shahriar Mobashery). 8. Metalloaminoglycosides: Chemistry and Biological Relevance (Nikhil Gokhale, Anjali Patwardhan, and J. A. Cowan). 9. Adverse Effects of Aminoglycoside Therapy (Andra E. Talaska and Jochen Schacht). 10. Targeting HIV-1 RNA with Aminoglycoside Antibiotics and Their Derivatives (Lev Elson-Schwab and Yitzhak Tor). 11. Novel Targets for Aminoglycosides (Dev P. Arya, Nicholas Shaw, and Hongjuan Xi). Index.
Series Title: Wiley series in drug discovery and development.
Responsibility: Dev P. Arya.
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"This is a 'must-have' text for anyone involved in AGA teaching or research. No better comprehensive treatise exists..." (Journal of Medicinal Chemistry, October 18, 2007) "There is little Read more...

 
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