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Analogue-based drug discovery III

Author: János Fischer; C R Ganellin; David P Rotella
Publisher: Weinheim : Wiley-VCH, [2013] ©2013
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
"Most drugs are analogue drugs. There are no general rules how a new drug can be discovered, nevertheless, there are some observations which help to find a new drug, and also an individual story of a drug discovery can initiate and help new discoveries. Volume III is a continuation of the successful book series with new examples of established and recently introduced drugs. The major part of the book is written by  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Analogue-based drug discovery III.
Weinheim : Wiley-VCH, [2013]
(OCoLC)825555931
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: János Fischer; C R Ganellin; David P Rotella
ISBN: 9783527651085 352765108X 9783527651115 352765111X 9781299241206 1299241204
OCLC Number: 826637765
Description: 1 online resource (xviii, 385 pages) : illustrations, portraits
Contents: General Aspects. Pioneer and Analogue Drugs / Janos Fischer, C Robin Ganellin, David P Rotella --
Competition in the Pharmaceutical Drug Development / Christian Tyrchan, Fabrizio Giordanetto --
Metabolic Stability and Analogue-Based Drug Discovery / Amit S Kalgutkar, Antonia F Stepan --
Use of Macrocycles in Drug Design Exemplified with Ulimorelin, a Potential Ghrelin Agonist for Gastrointestinal Motility Disorders / Mark L Peterson, Hamid Hoveyda, Graeme Fraser, Eric Marsault, Rene Gagnon --
Drug Classes. The Discovery of Anticancer Drugs Targeting Epigenetic Enzymes / A Ganesan --
Thienopyridyl and Direct-Acting P2Y Receptor Antagonist Antiplatelet Drugs / Joseph A Jakubowski, Atsuhiro Sugidachi --
Selective Estrogen Receptor Modulators / Amarjit Luniwal, Rachael Jetson, Paul Erhardt --
Discovery of Nonpeptide Vasopressin V2 Receptor Antagonists / Kazumi Kondo, Hidenori Ogawa --
The Development of Cysteinyl Leukotriene Receptor Antagonists / Peter R Bernstein --
Case Studies. The Discovery of Dabigatran Etexilate / Norbert Hauel, Andreas Clemens, Herbert Nar, Henning Priepke, Joanne van Ryn, Wolfgang Wienen --
The Discovery of Citalopram and Its Refinement to Escitalopram / Klaus P Bogeso, Connie Sanchez --
Tapentadol : From Morphine and Tramadol to the Discovery of Tapentadol / Helmut Buschmann --
Novel Taxanes: Cabazitaxel Case Study / Herve Bouchard, Dorothee Semiond, Marie-Laure Risse, Patricia Vrignaud --
Discovery of Boceprevir and Narlaprevir: A Case Study for Role of Structure-Based Drug Design / Srikanth Venkatraman, Andrew Prongay, George F Njoroge --
A New-Generation Uric Acid Production Inhibitor: Febuxostat / Ken Okamoto, Shiro Kondo, Takeshi Nishino.
Other Titles: Analogue-based drug discovery 3
Analog-based drug discovery III
Responsibility: edited by János Fischer, C. Robin Ganellin, David P. Rotella.

Abstract:

Most drugs are analogue drugs. There are no general rules how a new drug can be discovered, nevertheless, there are some observations which help to find a new drug, and also an individual story of a  Read more...

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The book s 15 chapters and 40 authors from 9 countries bring important, successful drug discoveries closer to medicinal chemists and all who are interested in the history of drug discoveries. The Read more...

 
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