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Anticancer drug development guide : preclinical screening, clinical trials, and approval

Author: Beverly A Teicher
Publisher: Totowa, N.J. : Humana Press, ©1997.
Series: Cancer drug discovery and development.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Experienced cancer researchers from pharmaceutical companies, government laboratories, and academia comprehensively review and describe in Dr. Beverly Teicher's Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval the arduous process of cancer drug discovery and approval. The expert contributors focus on using in vivo and in vitro methods preclinically to identify molecules of  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Anticancer drug development guide.
Totowa, N.J. : Humana Press, ©1997
(DLC) 96038113
(OCoLC)36084033
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Beverly A Teicher
ISBN: 9781461581529 1461581524 9781461581543 1461581540
OCLC Number: 645867661
Reproduction Notes: Electronic reproduction. [S.l.] : HathiTrust Digital Library, 2010. MiAaHDL
Description: 1 online resource (xii, 311 pages) : illustrations.
Details: Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.
Contents: pt. 1. In vitro methods --
High-volume screening --
The NCI in vitro anticancer drug discovery screen: concept, implementation, and operation, 1985-1995 --
Human tumor screening --
pt. 2. In vivo methods --
Murine L1210 and P388 leukemias --
In vivo methods for screening and preclinical testing: use of rodent solid tumors for drug discovery --
Human tumor xenograft models in NCI drug development --
Fertile seed and rich soil: the development of clinically relevant models of human cancer by surgical orthotopic implantation of intact tissue --
Preclinical models for high-dose therapy --
Models for minimal residual tumor --
Spontaneously occurring tumors in companion animals as models for drug development --
pt. 3. Clinical testing --
Working with the National Cancer Institute --
Phase I trial design and methodology --
Phase II clinical trials in oncology --
Drug development in Europe --
The phase III cancer clinical trial --
FDA role in cancer drug development and requirements for approval.
Series Title: Cancer drug discovery and development.
Responsibility: edited by Beverly A. Teicher.

Abstract:

This work analyzes the processes for the numerous steps involved in preclinical and clincial screening and approval of anticancer agents. It should be of interest to pharmacologists and oncologists.  Read more...

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"Authoritative and up-to-date...takes oncologists, pharmacologists, medicinal chemists and other cancer researchers on an encyclopedic tour of the cancer drug development and approval process, moving Read more...

 
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