skip to content
Antioxidants in disease mechanisms and therapy Preview this item
ClosePreview this item
Checking...

Antioxidants in disease mechanisms and therapy

Author: H Sies
Publisher: San Diego : Academic Press, ©1997.
Series: Advances in pharmacology (San Diego, Calif.), 38.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
Antioxidants in Disease Mechanisms and Therapy presents molecular actions of natural and synthetic antioxidants and emphasizes the potential role in disease mechanisms and therapeutic strategies. The modulationof gene expression by the induction of antioxidant enzymes is a novel role beyond the direct antioxidant action. The volume explores the current state of knowledge on oxidants and antioxidants in disease  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

Subjects
More like this

 

Find a copy online

Links to this item

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Genre/Form: Electronic books
Additional Physical Format: Print version:
Antioxidants in disease mechanisms and therapy.
San Diego : Academic Press, ©1997
(DLC) 96227565
(OCoLC)35842283
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: H Sies
ISBN: 9780080581309 0080581307 0120329395 9780120329397
OCLC Number: 371020133
Description: 1 online resource (xxiii, 707 pages) : illustrations.
Contents: Front Cover; Antioxidants in Disease Mechanisms and Therapy; Copyright Page; Contents; Contributors; Preface; Part I: Natural Antioxidants; Chapter 1. Antioxidants: The Basics-What They Are and How to Evaluate Them; I. Introduction; II. Biologically Relevant ROS/RNS; III. Proving That a Putative Antioxidant Is Important in Vivo; References; Chapter 2. Metabolism of Vitamin C in Health and Disease; I. Introduction and Overview; II. Changes in Vitamin C Status Associated with Disease; III. Mechanism of Changes in Vitamin C Status Associated with Disease. IV. Evidence for Therapeutic Effectiveness of Vitamin CV. Significance and Conclusions; References; Chapter 3. Regulation of Human Plasma Vitamin E; I. Introduction; II. Plasma Kinetics; III. Discrimination between Tocopherols; IV. Genetic Studies; V. Conclusions; References; Chapter 4. Glutathione and Glutathione Delivery Compounds; I. Glutathione; II. Glutathione Delivery Compounds; III. Summary; References; Chapter 5. a-Lipoic Acid: A Metabolic Antioxidant and Potential Redox Modulator of Transcription; I. Introduction; II. Role of Lipoate in Metabolism; III. Antioxidant Properties. IV. NF-kB Role in Normal and Abnormal Cell FunctionReferences; Chapter 6. Antioxidant Actions of Melatonin; I. Introduction; II. Melatonin as a Free Radical Scavenger; III. Melatonin as an Antioxidant; IV. Effect of Melatonin on Enzymes Related to the Antioxidative Defense System; V. Concluding Remarks; References; Chapter 7. Antioxidative and Metal-Chelating Effects of Polyamines; I. Introduction; II. Chemistry and Type Reactions of Polyamines; III. Antioxidative Effects of Polyamines; IV. Conclusions; References; Chapter 8. Antioxidant and Chelating Properties of Flavonoids; I. Introduction. II. Free Radical-Scavenging, Antioxidant, and Chelatory Activities of FlavonoidsIII. Prooxidant Activity of Flavonoids; IV. Cytotoxic Effects of Flavonoids against Tumor Cells; V. Mutagenic and Antimutagenic Properties of Flavonoids; References; Part II: Synthetic Antioxidants and Enzyme Mimics; Chapter 1. Potential Use of Iron Chelators against Oxidative Damage; I. Introduction; II. Iron Homeostasis; III. Iron Release during Oxidative Stress; IV. Iron Chelators; V. Protective Effect of Iron Chelators against Oxidative Damage; VI. Concluding Remarks; References. Chapter 2. N-Acetylcysteine: Pharmacological Considerations and Experimental and Clinical ApplicationsI. Introduction; II. Biopharmaceutical and Pharmacological Aspects; III. General Biochemical and Cellular Effects; IV. Specific Therapeutic Effects of NAC in Animals and Humans; V. Summary; References; Chapter 3. Ebselen as a Glutathione Peroxidase Mimic and as a Scavenger of Peroxynitrite; I. Introduction; II. Synthesis of Ebselen; III. Molecular Activities of Ebselen; IV. Activity in Biological Model Systems; V. Metabolism; VI. Clinical Assessment; VII. Other Selenoorganic Compounds.
Series Title: Advances in pharmacology (San Diego, Calif.), 38.
Responsibility: edited by Helmut Sies.

Abstract:

Presents molecular actions of natural and synthetic antioxidants and emphasizes the potential role in disease mechanisms and therapeutic strategies. This volume explores the state of knowledge on  Read more...

Reviews

Editorial reviews

Publisher Synopsis

Praise for the Serial "Recommended not only to pharmacologists but also to all those in related disciplines." --NATURE "The works do represent an extensive compilation of recent data by outstanding Read more...

 
User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.
Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/371020133> # Antioxidants in disease mechanisms and therapy
    a schema:Book, schema:CreativeWork, schema:MediaObject ;
   library:oclcnum "371020133" ;
   library:placeOfPublication <http://experiment.worldcat.org/entity/work/data/793862517#Place/san_diego> ; # San Diego
   library:placeOfPublication <http://id.loc.gov/vocabulary/countries/cau> ;
   schema:about <http://experiment.worldcat.org/entity/work/data/793862517#Topic/radicaux_libres_chimie_physiopathologie> ; # Radicaux libres (Chimie)--Physiopathologie
   schema:about <http://experiment.worldcat.org/entity/work/data/793862517#Topic/antioxidants> ; # Antioxidants
   schema:about <http://experiment.worldcat.org/entity/work/data/793862517#Topic/antioxidants_therapeutic_use> ; # Antioxidants--therapeutic use
   schema:about <http://experiment.worldcat.org/entity/work/data/793862517#Topic/antioxidanten> ; # Antioxidanten
   schema:about <http://dewey.info/class/616.07/e22/> ;
   schema:about <http://id.worldcat.org/fast/810647> ; # Antioxidants--Therapeutic use
   schema:about <http://experiment.worldcat.org/entity/work/data/793862517#Topic/antioxidants_pharmacology> ; # Antioxidants--pharmacology
   schema:about <http://id.loc.gov/authorities/subjects/sh2009115041> ; # Antioxidants--Health aspects
   schema:about <http://id.worldcat.org/fast/933920> ; # Free radicals (Chemistry)--Pathophysiology
   schema:about <http://experiment.worldcat.org/entity/work/data/793862517#Topic/antioxydants_aspect_sanitaire> ; # Antioxydants--Aspect sanitaire
   schema:about <http://id.loc.gov/authorities/subjects/sh2009113512> ; # Antioxidants--Therapeutic use
   schema:about <http://experiment.worldcat.org/entity/work/data/793862517#Topic/medical_pathology> ; # MEDICAL--Pathology
   schema:about <http://id.worldcat.org/fast/810644> ; # Antioxidants--Health aspects
   schema:about <http://experiment.worldcat.org/entity/work/data/793862517#Topic/antioxydants_emploi_en_therapeutique> ; # Antioxydants--Emploi en thérapeutique
   schema:about <http://id.loc.gov/authorities/subjects/sh2008104080> ; # Free radicals (Chemistry)--Pathophysiology
   schema:about <http://experiment.worldcat.org/entity/work/data/793862517#Topic/medical_pathophysiology> ; # MEDICAL--Pathophysiology
   schema:bookFormat schema:EBook ;
   schema:contributor <http://viaf.org/viaf/108761420> ; # Helmut Sies
   schema:copyrightYear "1997" ;
   schema:datePublished "1997" ;
   schema:description "Antioxidants in Disease Mechanisms and Therapy presents molecular actions of natural and synthetic antioxidants and emphasizes the potential role in disease mechanisms and therapeutic strategies. The modulationof gene expression by the induction of antioxidant enzymes is a novel role beyond the direct antioxidant action. The volume explores the current state of knowledge on oxidants and antioxidants in disease processes, including arteriosclerosis, adult respiratory distress syndrome, cystic fibrosis, Down's syndrome, inflammation, cataract, age-related macular degeneration, afflications of the nervous system, AIDS, liver diseases, diabetes, skin diseases, and cancer. Key Features * Contains cutting-edge information on focused topics written by expert scientists * Provides the first in-depth treatment of novel compounds, such as melatonin and polyamines * Attempts molecular pathophysiology which links basic science and the clinic * Presents critical assessment of controversial topics."@en ;
   schema:description "Front Cover; Antioxidants in Disease Mechanisms and Therapy; Copyright Page; Contents; Contributors; Preface; Part I: Natural Antioxidants; Chapter 1. Antioxidants: The Basics-What They Are and How to Evaluate Them; I. Introduction; II. Biologically Relevant ROS/RNS; III. Proving That a Putative Antioxidant Is Important in Vivo; References; Chapter 2. Metabolism of Vitamin C in Health and Disease; I. Introduction and Overview; II. Changes in Vitamin C Status Associated with Disease; III. Mechanism of Changes in Vitamin C Status Associated with Disease."@en ;
   schema:exampleOfWork <http://worldcat.org/entity/work/id/793862517> ;
   schema:genre "Electronic books"@en ;
   schema:inLanguage "en" ;
   schema:isPartOf <http://experiment.worldcat.org/entity/work/data/793862517#Series/advances_in_pharmacology> ; # Advances in pharmacology ;
   schema:isPartOf <http://experiment.worldcat.org/entity/work/data/793862517#Series/advances_in_pharmacology_san_diego_calif> ; # Advances in pharmacology (San Diego, Calif.) ;
   schema:isSimilarTo <http://www.worldcat.org/oclc/35842283> ;
   schema:name "Antioxidants in disease mechanisms and therapy"@en ;
   schema:productID "371020133" ;
   schema:publication <http://www.worldcat.org/title/-/oclc/371020133#PublicationEvent/san_diego_academic_press_1997> ;
   schema:publisher <http://experiment.worldcat.org/entity/work/data/793862517#Agent/academic_press> ; # Academic Press
   schema:url <http://www.myilibrary.com?id=171228> ;
   schema:url <http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=241575> ;
   schema:url <http://www.sciencedirect.com/science/bookseries/10543589/38> ;
   schema:url <http://public.eblib.com/choice/publicfullrecord.aspx?p=403521> ;
   schema:url <http://site.ebrary.com/id/10240207> ;
   schema:url <http://www.sciencedirect.com/science/book/9780120329397> ;
   schema:workExample <http://worldcat.org/isbn/9780080581309> ;
   schema:workExample <http://worldcat.org/isbn/9780120329397> ;
   wdrs:describedby <http://www.worldcat.org/title/-/oclc/371020133> ;
    .


Related Entities

<http://experiment.worldcat.org/entity/work/data/793862517#Series/advances_in_pharmacology> # Advances in pharmacology ;
    a bgn:PublicationSeries ;
   schema:hasPart <http://www.worldcat.org/oclc/371020133> ; # Antioxidants in disease mechanisms and therapy
   schema:name "Advances in pharmacology ;" ;
    .

<http://experiment.worldcat.org/entity/work/data/793862517#Series/advances_in_pharmacology_san_diego_calif> # Advances in pharmacology (San Diego, Calif.) ;
    a bgn:PublicationSeries ;
   schema:hasPart <http://www.worldcat.org/oclc/371020133> ; # Antioxidants in disease mechanisms and therapy
   schema:name "Advances in pharmacology (San Diego, Calif.) ;" ;
    .

<http://experiment.worldcat.org/entity/work/data/793862517#Topic/antioxidants_pharmacology> # Antioxidants--pharmacology
    a schema:Intangible ;
   schema:name "Antioxidants--pharmacology"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/793862517#Topic/antioxidants_therapeutic_use> # Antioxidants--therapeutic use
    a schema:Intangible ;
   schema:name "Antioxidants--therapeutic use"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/793862517#Topic/antioxydants_aspect_sanitaire> # Antioxydants--Aspect sanitaire
    a schema:Intangible ;
   schema:name "Antioxydants--Aspect sanitaire"@fr ;
    .

<http://experiment.worldcat.org/entity/work/data/793862517#Topic/antioxydants_emploi_en_therapeutique> # Antioxydants--Emploi en thérapeutique
    a schema:Intangible ;
   schema:name "Antioxydants--Emploi en thérapeutique"@fr ;
    .

<http://experiment.worldcat.org/entity/work/data/793862517#Topic/medical_pathology> # MEDICAL--Pathology
    a schema:Intangible ;
   schema:name "MEDICAL--Pathology"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/793862517#Topic/medical_pathophysiology> # MEDICAL--Pathophysiology
    a schema:Intangible ;
   schema:name "MEDICAL--Pathophysiology"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/793862517#Topic/radicaux_libres_chimie_physiopathologie> # Radicaux libres (Chimie)--Physiopathologie
    a schema:Intangible ;
   schema:name "Radicaux libres (Chimie)--Physiopathologie"@fr ;
    .

<http://id.loc.gov/authorities/subjects/sh2008104080> # Free radicals (Chemistry)--Pathophysiology
    a schema:Intangible ;
   schema:name "Free radicals (Chemistry)--Pathophysiology"@en ;
    .

<http://id.loc.gov/authorities/subjects/sh2009113512> # Antioxidants--Therapeutic use
    a schema:Intangible ;
   schema:name "Antioxidants--Therapeutic use"@en ;
    .

<http://id.loc.gov/authorities/subjects/sh2009115041> # Antioxidants--Health aspects
    a schema:Intangible ;
   schema:name "Antioxidants--Health aspects"@en ;
    .

<http://id.worldcat.org/fast/810644> # Antioxidants--Health aspects
    a schema:Intangible ;
   schema:name "Antioxidants--Health aspects"@en ;
    .

<http://id.worldcat.org/fast/810647> # Antioxidants--Therapeutic use
    a schema:Intangible ;
   schema:name "Antioxidants--Therapeutic use"@en ;
    .

<http://id.worldcat.org/fast/933920> # Free radicals (Chemistry)--Pathophysiology
    a schema:Intangible ;
   schema:name "Free radicals (Chemistry)--Pathophysiology"@en ;
    .

<http://viaf.org/viaf/108761420> # Helmut Sies
    a schema:Person ;
   schema:birthDate "1942" ;
   schema:familyName "Sies" ;
   schema:givenName "Helmut" ;
   schema:givenName "H." ;
   schema:name "Helmut Sies" ;
    .

<http://worldcat.org/isbn/9780080581309>
    a schema:ProductModel ;
   schema:isbn "0080581307" ;
   schema:isbn "9780080581309" ;
    .

<http://worldcat.org/isbn/9780120329397>
    a schema:ProductModel ;
   schema:isbn "0120329395" ;
   schema:isbn "9780120329397" ;
    .

<http://www.sciencedirect.com/science/bookseries/10543589/38>
   rdfs:comment "to access electronic resource" ;
    .

<http://www.worldcat.org/oclc/35842283>
    a schema:CreativeWork ;
   rdfs:label "Antioxidants in disease mechanisms and therapy." ;
   schema:description "Print version:" ;
   schema:isSimilarTo <http://www.worldcat.org/oclc/371020133> ; # Antioxidants in disease mechanisms and therapy
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.