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Apoptosis, genomic integrity, and cancer

Author: Julien L Van Lancker
Publisher: Sudbury, Mass. : Jones and Bartlett Publishers, ©2006.
Edition/Format:   Print book : EnglishView all editions and formats
Database:WorldCat
Summary:
Harmonious survival of the entire organism depends on the rigorous preservation of the controls that regulate the balance between the cell's replication and apoptosis. This balance depends largely, although not exclusively, on the integrity of the genome. Cancer is a flagrant illustration of the danger of imbalance between cell proliferation and cell death. As cells replicate unfettered by normal controls, they  Read more...
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Additional Physical Format: Online version:
Van Lancker, Julien L., 1924-
Apoptosis, genomic integrity, and cancer.
Sudbury, Mass. : Jones and Bartlett Publishers, ©2006
(OCoLC)606070841
Document Type: Book
All Authors / Contributors: Julien L Van Lancker
ISBN: 0763745413 9780763745417
OCLC Number: 60543262
Description: xviii, 422 pages : illustrations ; 26 cm
Contents: Morphology and occurrence of apoptosis --
Recognition and disposal of the apoptotic bodies --
Agents that trigger apoptosis --
Genes and gene products in apoptosis of C. elegans --
The Bc1-2 family --
Interleukin 1-B [beta] Converting enzyme (ICE) and caspases --
The cytochrome c-Dependent pathway to apoptosis --
Inhibitor of apoptosis proteins (IAPs) --
The p53 Gene --
Integrity of the genome and programmed cell death --
Enzymes potentially involved in P53 activation --
P53 and the cell cycle --
Cell cycle checkpoints --
Cell cycle arrest --
P53 transactivation of GADD45 and MDM2 --
The P53 family and apoptosis --
Tumor transorming growth factors and cancer --
Protein tyrosine kinase receptors and cancer --
The oncogenic GTPases --
Non-receptor protein kinases and cancer --
The PiK3/AKT pathway cancer and apoptosis --
Transcription factors and cancer --
Cancer and genomic instability --
Cancer and genomic instability: mismatch repair and cancer --
Role of Fanconi anemia, breast cancer, and bloom syndrome genes in oncogenesis --
Cancer and apoptosis.
Responsibility: Julien L. Van Lancker.
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Abstract:

This book introduces readers to the molecules involved in apoptosis and genomal integrity and considers the gain or loss of the functions that lead to cancer.  Read more...

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