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Applied Dermatotoxicology : Clinical Aspects.

Author: Howard Maibach; Golara Honari
Publisher: Burlington : Elsevier Science, 2014.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
Applied Dermatotoxicology: Clinical Aspects provides concise, systematic, and state-of-the-art information on the toxicological effects of substances on skin, and recent advances in dermal toxicity testing. This book specifically addresses the clinical presentations borne out of exposure to a variety of chemicals. It begins with an overview of skin biology to provide toxicologists with a basic understanding of its  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Maibach, Howard.
Applied Dermatotoxicology : Clinical Aspects.
Burlington : Elsevier Science, ©2014
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Howard Maibach; Golara Honari
ISBN: 9780124201996 0124201997
OCLC Number: 882769900
Notes: Additional Series of Patch Tests.
Description: 1 online resource (150 pages)
Contents: Front Cover; Applied Dermatotoxicology: Clinical Aspects; Copyright Page; Contents; List of Contributors; Preface; 1 Skin Structure and Function; Introduction; Structure and Function; Epidermis; Dermis; Hypodermis; Skin Appendages; Skin a Route of Entry; Measuring Skin; Skin Surface pH; Sebum; Desquamation; Thickness; The Measurement of Transepidermal Water Loss; Hydration Measurement; Measurement of Vascular Perfusion; References; 2 Irritant Contact Dermatitis: Clinical Aspects; Introduction; Clinical Manifestations of Irritant Dermatitis; Irritant Reaction; Acute Irritant Dermatitis. Delayed Acute Irritant DermatitisChronic Cumulative ICD; Chemical Burns; Special Clinical Forms of Irritant Dermatitis; Pustular and Acneiform Irritant Dermatitis; Sensory Irritation; Airborne Irritant Dermatitis; Irritant Dermatitis from Physical Factors; Summary; References; Toxicology; Introduction; Predictive In Vitro Testing; Corrosion Testing; Transcutaneous Electrical Resistance Test Method; Membrane Barrier Test Method for Skin Corrosion; Reconstructed Human Epidermis Test Method; Irritation Testing; In Vitro RhE Test Method; Predictive In Vivo Testing. Acute Dermal Irritation/Corrosion TestingInitial Test (In Vivo Dermal Irritation/Corrosion); Confirmatory Test (In Vivo Dermal Irritation); The Draize Rabbit Skin Irritancy Test; Human Irritation Testing; Single-Application Irritation Patch Test; Repeat-Application Cumulative Irritation Patch Test; Exaggerated Exposure Irritation Tests; Use of Bioengineering Devices; References; 3 Photoirritation (Phototoxicity): Clinical Aspects; Introduction; Basic Principles of Photobiology; Mechanisms of Phototoxic Reactions; Clinical Presentations; Main Topical and Systemic Photosensitizers; Summary. Stage 3A of ACDSStage 3B of ACDS; ICD Versus ACD: Clinical Aspects; Topography; Timing of Evolution; Subjective Symptoms; Conclusion; Hand Eczema (Hand Dermatitis) and ACD; Various Clinical Aspects of ACD of the Hands; Overlapping of Eczematous Lesions of the Hands; Protein Contact Dermatitis; Photoallergic Contact Dermatitis; ACD: The Patch Test, First-Line Diagnostic Tool; Reading Time; Scoring Patch Test Results; Dealing with Doubtful Reactions (?+); Clinical Relevance of Patch Test Reactions; Photopatchtest; The Series of Patch Test Allergens; The Baseline (Standard) Series.

Abstract:

Applied Dermatotoxicology: Clinical Aspects provides concise, systematic, and state-of-the-art information on the toxicological effects of substances on skin, and recent advances in dermal toxicity testing. This book specifically addresses the clinical presentations borne out of exposure to a variety of chemicals. It begins with an overview of skin biology to provide toxicologists with a basic understanding of its anatomy and physiology. Next it presents a variety of dermatotoxicological effects, as well at the toxic agents that cause them, with color photographs to illustrat.

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