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Approaches to the conformational analysis of biopharmaceuticals

Author: Roger L Lundblad
Publisher: Boca Raton : CRC Press, ©2010.
Series: Protein science series.
Edition/Format:   Book : EnglishView all editions and formats
Database:WorldCat
Summary:

Conformational analysis is becoming more critical in the development of generic biopharmaceuticals. This book covers physical methods, such as differential scanning calorimetry, light scanning, and  Read more...

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Document Type: Book
All Authors / Contributors: Roger L Lundblad
ISBN: 9781439807804 1439807809
OCLC Number: 403362096
Description: xiii, 354 pages : illustrations ; 25 cm.
Contents: Introduction to biopharmaceutical conformational analysis : issues and methods --
Comparability of biotechnological/biological products and biological generics --
Application of native electrophoresis for the study of protein conformation --
Affinity chromatography including hydrophobic interaction chromatography in the study of biopolymer conformation --
Size-exclusion chromatography and bimolecular conformation --
Use of analytical ultracentrifugation to study biomolecular conformation --
Use of differential scanning calorimetry to measure conformational change in proteins and other biomacromolecules --
Light scattering and biomacromolecular conformation --
Use of luminescence to measure conformational change in biopharmaceuticals with emphasis on protein and protein drug products --
Near-infrared spectroscopy and macromolecular conformation --
Use of mid-infrared and Fourier transform infrared spectroscopy to study conformation of biomacromolecules --
Use of Raman spectroscopy to evaluate biopharmaceutical conformation --
The use of UV-VIS spectrophotometry for the characterization of biopharmaceutical products --
Use of optical rotatory dispersion and circular dichroism to study therapeutic biomacromolecule conformation --
Use of nuclear magnetic resonance for the characterization of biotherapeutic products --
Use of chemical probes for the study of protein conformation --
Use of hydrogen exchange in the study of biopharmaceutical conformation --
Use of chemical modification for the conformational analysis of biopharmaceuticals --
Use of immunology to characterize biopharmaceutical conformation --
Use of limited proteolysis to study the conformation of proteins of biotechnological interest --
Other technologies for the characterization of conformational change in biopharmaceuticals --
Development of an experimental approach for the study of the conformation of a biological therapeutic product.
Series Title: Protein science series.
Responsibility: Roger L. Lundblad.
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"Lundblad (pathology, U. of North Carolina at Chapel Hill) provides coverage of the range of technology used for the conformational analysis of biopharmaceutical polymers, intending to provide Read more...

 
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