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Approaches to the conformational analysis of biopharmaceuticals

Autore: Roger L Lundblad
Editore: Boca Raton : CRC Press, ©2010.
Serie: Protein science series.
Edizione/Formato:   Libro : EnglishVedi tutte le edizioni e i formati
Banca dati:WorldCat
Sommario:

Conformational analysis is becoming more critical in the development of generic biopharmaceuticals. This book covers physical methods, such as differential scanning calorimetry, light scanning, and  Per saperne di più…

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Tipo documento: Book
Tutti gli autori / Collaboratori: Roger L Lundblad
ISBN: 9781439807804 1439807809
Numero OCLC: 403362096
Descrizione: xiii, 354 pages : illustrations ; 25 cm.
Contenuti: Introduction to biopharmaceutical conformational analysis : issues and methods --
Comparability of biotechnological/biological products and biological generics --
Application of native electrophoresis for the study of protein conformation --
Affinity chromatography including hydrophobic interaction chromatography in the study of biopolymer conformation --
Size-exclusion chromatography and bimolecular conformation --
Use of analytical ultracentrifugation to study biomolecular conformation --
Use of differential scanning calorimetry to measure conformational change in proteins and other biomacromolecules --
Light scattering and biomacromolecular conformation --
Use of luminescence to measure conformational change in biopharmaceuticals with emphasis on protein and protein drug products --
Near-infrared spectroscopy and macromolecular conformation --
Use of mid-infrared and Fourier transform infrared spectroscopy to study conformation of biomacromolecules --
Use of Raman spectroscopy to evaluate biopharmaceutical conformation --
The use of UV-VIS spectrophotometry for the characterization of biopharmaceutical products --
Use of optical rotatory dispersion and circular dichroism to study therapeutic biomacromolecule conformation --
Use of nuclear magnetic resonance for the characterization of biotherapeutic products --
Use of chemical probes for the study of protein conformation --
Use of hydrogen exchange in the study of biopharmaceutical conformation --
Use of chemical modification for the conformational analysis of biopharmaceuticals --
Use of immunology to characterize biopharmaceutical conformation --
Use of limited proteolysis to study the conformation of proteins of biotechnological interest --
Other technologies for the characterization of conformational change in biopharmaceuticals --
Development of an experimental approach for the study of the conformation of a biological therapeutic product.
Titolo della serie: Protein science series.
Responsabilità: Roger L. Lundblad.
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"Lundblad (pathology, U. of North Carolina at Chapel Hill) provides coverage of the range of technology used for the conformational analysis of biopharmaceutical polymers, intending to provide Per saperne di più…

 
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