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|Additional Physical Format:||Approche semi-covalente pour la préparation de polymères imprimés par la technique de polymérisation en mini-émulsion [Texte imprimé] / Pascale Curcio
[S.l.] : [s.n.], 2009
1 vol. (189 p.)
|Material Type:||Document, Thesis/dissertation, Internet resource|
|Document Type:||Internet Resource, Computer File|
|All Authors / Contributors:||
Pasquale Curcio; Alain Wagner; Charles Mioskowski; Université de Strasbourg (2009-....).
|Notes:||Titre provenant de l'écran-titre.|
|Description:||1 online resource.|
|Details:||AcceÌs : Internet, reÌserveÌ aux usagers de l'UniversiteÌ de Strasbourg.|
|Responsibility:||Pascale Curcio ; [sous la direction de ] Alain Wagner et Charles Mioskowski.|
Molecular imprinting is a technique that enables the preparation of synthetic receptors in a highly cross-linked polymer matrix. This technique has known a remarkable development in recent decades, and has currently a large number of potential applications, such as stationary phase for chromatographic columns, as a support in solid phase extraction (SPE), as nanoreactors and as catalysts. During my thesis work, we developed a new method for the preparation of surface imprinted nanospheres, combining for the first time the semi-covalent approach with the miniemulsion polymerization. As a first step, we wanted to assess the parameters that influence the selectivity of molecular imprinted polymers (MIPs) prepared with this new imprinting technique. We prepared different imprinted polymers with an increasing number of carboxylic acid functions in the binding sites, using phosphorous templates. This increase leads to the generation of an artificial receptor with greater selectivity for the recognition of original analytes. Then, we applied the new imprinting technique to the preparation of artificial receptors for glucose derivative. The imprinted polymer showed an excellent imprinted factor and a remarkable selectivity for glucose, compared to other epimers. The selectivity factor found between glucopyranoside and galactopyranoside is the highest reported so far.