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The aptamer handbook : functional oligonucleotides and their applications

Author: Sven Klussmann
Publisher: Weinheim : Wiley-VCH, ©2006.
Edition/Format:   Print book : EnglishView all editions and formats
Database:WorldCat
Summary:

Concepts and procedures for the generation and application of aptamers (target-binding oligonucleotides) and aptazymes (catalytically active oligonucleotides) are presented in this first  Read more...

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Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Sven Klussmann
ISBN: 9783527310593 3527310592
OCLC Number: 64571983
Description: xxviii, 490 pages : illustrations
Contents: In vitro selection of functional oligonucleotides and the origins of biochemical activity / James M. Carothers and Jack W. Szostak --
Mathematical models on RNA evolution, simulations in silico, and concepts for in vitro selection / Peter Schuster --
Fitness landscapes, error thresholds, and cofactors in aptamer evolution / Ádam Kun [and others] --
Aptamers to small molecules / Heiko Fickert, Iris G. Fransson, and Ulrich Hahn --
Aptamers to antibiotics / Christina Lorenz and Renée Schroeder --
Aptamers to proteins / Shahid M. Nimjee, Christopher P. Rusconi, and Bruce A. Sullenger --
Aptamers to nucleic acid structures / Jean-Jacques Toulmé [and others] --
Riboswitches : natural metabolite-binding RNAs controlling gene expression / Adam Roth, Rüdiger Welz, and Ronald R. Breaker --
Catalytically active RNA molecules : tools in organic chemistry / Barbara-Sylvia Weigand [and others] --
Deoxyribozymes : catalytically active DNA molecules / Kenny Schlosser, Simon A. McManus, and Yingfu Li --
In vivo and in vitro target validation with nucleic acid aptamers as pharmacological probes / P. Shannon Pendergrast and David M. Epstein --
Intramers for protein function analysis and drug discovery / Michael Famulok and Günter Mayer --
Aptazymes : allosteric ribozymes and deoxyribozymes and biosensors / Scott M. Knudsen and Andrew D. Ellington --
Conversion of aptamers into small-molecule lead compounds / Andreas Jenne --
Aptamers as ligands for affinity chromatography and capillary electrophoresis applications / Eric Peyrin --
Aptamers for in vivo imaging / Sandra Borkowski and Ludger M. Dinkelborg --
Properties of therapeutic aptamers / Sharon T. Cload [and others] --
Spiegelmers for therapeutic applications : use of chiral principles in evolutionary selection techniques / Dirk Eulberg [and others] --
Applications in the clinic : the anti-vegf aptamer / Tony Realini, Eugene W.M. Ng, and Anthony P. Adamis --
A personal perspective : aptamers after 15 years / Larry Gold.
Responsibility: edited by Sven Klussmann.
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"Considering the overall effort by the editor to gather work by some of the leading researchers on aptamers, I believe The Aptamer Handbook will be referred to as an encyclopedia on aptamer research. Read more...

 
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