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Arrestins-- Pharmacology and therapeutic potential

Author: Vsevolod V Gurevich
Publisher: Heidelberg : Springer, 2014.
Series: Handbook of experimental pharmacology, v.219.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
This volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing on the mechanisms of arrestin-mediated regulation of GPCRs and non-receptor signaling proteins in health and disease. The book covers wide range of arrestin functions, emphasizing therapeutic potential of targeting arrestin interactions with individual partners.
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Vsevolod V Gurevich
ISBN: 9783642411991 3642411991
OCLC Number: 869745420
Description: 1 online resource (viii, 447 pages) : illustrations (some color).
Contents: Therapeutic potential of small molecules and engineered proteins.-arrestin interactions with g protein-coupled receptors --
arrestin-biased gpcr¡agonists --
arrestin-1 expression levels, rod function and health --
protective functions of arrestin-1 in photoreceptors --
arrestin-4 and cone function --
enhanced phosphorylation-independent arrestins and gene therapy --
targeting particular receptors with redesigned non-visual arrestins.-¡arrestins binding to clathrin, ap2 and role in gpcr trafficking --
arrestins in ubiquitination and deubiquitination --
arrestin self-association --
arrestin-dependent activation of erk and src --
arrestin-dependent activation of jnk family kinases --
arrestin-mediated p38 activation.-¡arrestin-dependent pde localization --
arrestins in cell migration --
arrestins in host-pathogen interactions --
arrestin regulation of small gtpases --
gpcrs and arrestins in airways: implications for asthma --
arrestins as regulatory signaling hubs in cancer pathways --
arrestins in pain and anesthesia.
Series Title: Handbook of experimental pharmacology, v.219.
Responsibility: Vsevolod V. Gurevich, editor.
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