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Arterial mesenchyme and arteriosclerosis; [proceedings]

Author: William D Wagner; Thomas B Clarkson
Publisher: New York, Plenum Press [1974]
Series: Advances in experimental medicine and biology, v. 43.
Edition/Format:   Print book : Conference publication : EnglishView all editions and formats
Summary:
Presently, and in the past, the predominant investigative emphasis among research workers in arteriosclerosis has been on plasma and arterial lipids. Recent data from a number of laboratories suggest that arterial mesenchyme is of considerable importance in the pathogenesis and fate of arteriosclerotic lesions. The significance of some of these observations made it clear that here was need for intensified research  Read more...
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Genre/Form: Congresses
Conference papers and proceedings
Additional Physical Format: Online version:
International Workshop on Arterial Mesenchyme and Arteriosclerosis (1973 : New Orleans).
Arterial mesenchyme and arteriosclerosis.
New York, Plenum Press [1974]
(OCoLC)610147845
Material Type: Conference publication
Document Type: Book
All Authors / Contributors: William D Wagner; Thomas B Clarkson
ISBN: 0306390434 9780306390432
OCLC Number: 866505
Description: xv, 431 pages illustrations 26 cm.
Contents: Section I The Problem in Perspective.- Mesenchymal Involvement in Arteriosclerosis.- Morphology of Mesenchymal Elements of Normal Artery, Fatty Streaks, and Plaques.- Reaction Patterns of Intimal Mesenchyme to Injury, and Repair in Atherosclerosis.- Proliferation of Arterial Cells in Atherosclerosis.- Section II Lipid-Connective Tissue Interactions.- The Macromolecules of the Intercellular Matrix of the Arterial Wall: Collagen, Elastin, Proteoglycans, and Glycoproteins.- Acid Glycosaminoglycan, Collagen and Elastin Content of Normal Artery, Fatty Streaks and Plaques.- Mucopolysaccharide-Lipoprotein Complexes in Atherosclerotic Aorta.- Some Aspects of the Organization and Interaction of Connective Tissue Proteoglycans.- Age Related and Atherosclerotic Changes in Aortic Elastin.- Components of the Protein-Lipid Complex of Arterial Elastin: Their Role in the Retention of Lipid in Atherosclerotic Lesions.- Studies on the Conformation and Interactions of Elastin.- Section III Tissue Culture Application in Connective Tissue Research.- Tissue Culture Technology Applicable to Arterial Mesenchyme.- Studies of Primate Arterial Smooth Muscle Cells in Relation to Atherosclerosis.- Production of Mucopolysaccharides, Collagen and Elastin Tissue by Aortic Medial Explants.- Effects of Serum Lipoproteins on the Morphology, Growth, and Metabolism of Arterial Smooth Muscle Cells.- Section IV Pathologic Processes and Connective Tissue Interactions.- Thrombosis and Connective Tissue Interrelationships in Arteriosclerosis.- Immunological Properties of Connective Tissue and Smooth Muscle Cells.- Immunologic Injury and Atherosclerosis.- Enzymic vs Non-Enzymic Factors in the Deterioration of Connective Tissue.- Calcification Processes in Atherosclerosis.
Series Title: Advances in experimental medicine and biology, v. 43.
Responsibility: Edited by William D. Wagner and Thomas B. Clarkson.

Abstract:

Presently, and in the past, the predominant investigative emphasis among research workers in arteriosclerosis has been on plasma and arterial lipids. Recent data from a number of laboratories suggest that arterial mesenchyme is of considerable importance in the pathogenesis and fate of arteriosclerotic lesions. The significance of some of these observations made it clear that here was need for intensified research on the connective tissue components of the arteriosclerotic lesion and that arterioscle research workers could benefit from a more comprehensive view of the subject. Because of their experience in the field of arteriosclerosis and their interest in stimulating new directions for research on the lesion, the Committee on Coronary Artery Lesions and Myocardial Infarctions of the Council on Arteriosclerosis, American Heart Association, planned an International Workshop on Arterial Mesenchyme and Arteriosclerosis. The Workshop brought together scientists expert in connective tissue research and research on arteriosclerosis who presented the current status of knowledge in their areas of expertise. The Workshop was held April 2-3, 1973 at the Royal Orleans Hotel, New Orleans, Louisiana and was attended by more than 170 people. The twenty papers and discussions presented in this volume summarize the proceedings of the Workshop and represent a comprehensive review of the role of arterial mesenchyme in arteriosclerosis. The first section of the volume sets the problem in perspective and includes papers by several expert participants who define the mesenchymal components with respect to the arterial wall and the arteriosclerotic lesion. The Workshop then addressed itself to the interaction of lipids with the various connective tissue components such as collagen, elastin, glycosaminoglycans, and glycoproteins. The third section of papers is intended to stimulate interest in tissue culture technology and deals with culture techniques applicable in the study of arteriosclerosis. The final series of papers addresses the pathologic processes resulting from the interactions of connective tissue components and the arterial wall. We are hopeful that the Workshop and the published proceedings will stimulate investigators to undertake specific new directions in investigating the pathogenesis of arteriosclerosis, including progression and regression of lesions, based on new knowledge of mesenchymal tissues. One of our aims was to publish and disseminate to other investigators in arteriosclerosis and connective tissue research the information presented at the workshop as soon as possible. In this regard we apologize for any unavoidable form and stylistic imperfections. During the printing process for the book all illustrations were reduced 10% in addition to any reductions listed for figures.

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