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Aspartic acid proteases as therapeutic targets

Author: Arun K Ghosh, Prof. Dr.
Publisher: Weinheim : Wiley-VCH, ©2010.
Series: Methods and principles in medicinal chemistry, v. 45.
Edition/Format:   Print book : EnglishView all editions and formats

In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of  Read more...


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Genre/Form: Aufsatzsammlung
Document Type: Book
All Authors / Contributors: Arun K Ghosh, Prof. Dr.
ISBN: 9783527318117 3527318119
OCLC Number: 620364633
Description: xxiii, 615 pages : illustrations.
Contents: OVERVIEW OF ASPARTIC ACID PROTEASES Introduction to the Aspartic Proteases Family Aspartic Acid Proteases, Structure, Function and Inhibition Human Aspartic Proteinases Structure-based Drug Design Strategies for the Inhibition of Aspartic Acid Proteases HIV-1 PROTEASE FOR THE TREATMENT OF HIV/AIDS HIV-1 Protease: Role in Viral Replication, Protein-Ligand X-ray Crystal Structures and Inhibitor Design First generation FDA Approved HIV protease inhibitors Second-Generation Approved HIV Protease Inhibitors for Treatment of HIV/AIDS Design, Conception and Clinical Development of Darunavir, a HIV-1 Protease Inhibitor to Combat Drug Resistance Development of Protease Inhibitors and Challenges to Drug-Resistance of HIV-1 RENIN FOR TREATMENT OF HYPERTENSION Discovery and Development of Aliskiren, the First-in-Class Direct Renin Inhibitor for the Treatment of Hypertension Evolution of Diverse Classes of Renin Inhibitors Through the Years GAMMA-SECRETASE FOR TREATMENT OF ALZHEIMER'S DISEASE Chemistry and Biology of gamma-Secretase as a Possible Target for Alzheimer's Disease Gamma-Secretase Inhibition: An overview of Development of Inhibitors for Alzheimer's Disease BETA-SECRETASE FOR TREATMENT OF ALZHEIMER'S DISEASE BACE - An (Almost) Perfect Target for Staving Off Alzheimer's Disease Discovery of Memapsin 2 (BACE1), Design of Inhibitors and Drug-design Tools Peptidomimetic BACE1 Inhibitors for Treatment of Alzheimer's Disease: Design and Evolution Non-Peptide BACE1 Inhibitors: Design and Synthesis PLASMEPSINS AND OTHER ASPARTIC PROTEASES AS DRUG TARGETS The Plasmepsin Family as Antimalarial Drug Targets Design and Synthesis of Plasmepsin Inhibitors for Treatment of Malaria Fungal aspartic proteases as possible therapeutic targets
Series Title: Methods and principles in medicinal chemistry, v. 45.
Responsibility: edited by Arun K. Ghosh.


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"Overall, this book comprises an excellent themes and publications based on aspartic protease research, and I strongly recommend this book for novices, as well as experienced researchers in this Read more...

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