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Aspartic Proteinases : Structure, Function, Biology, and Biomedical Implications

Author: Kenji Takahashi
Publisher: Boston, MA : Springer US : Imprint : Springer, 1995.
Series: Advances in experimental medicine and biology, 362.
Edition/Format:   eBook : Bibliographic data : EnglishView all editions and formats

The 5th International Conference on Aspartic Proteinases was held on September 19 through 24, 1993, at Naito Museum of Pharmaceutical Science and Industry, Kawashima- cho, Gifu Prefecture, Japan,  Read more...


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Genre/Form: Electronic books
Conference papers and proceedings
Additional Physical Format: Printed edition:
Material Type: Bibliographic data, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Kenji Takahashi
ISBN: 9781461518716 1461518717 9781461357612 1461357616
OCLC Number: 840283895
Description: 1 online resource (656 pages).
Contents: Gastric Aspartic Proteinases: Plenary Lectures.- 1. Comparison of the Active Site Specificity of the Aspartic Proteinases Based on a Systematic Series of Peptide Substrates.- 2. The Molecular Structure of Human Progastricsin and Its Comparison with that of Porcine Pepsinogen.- 3. A New Way of Looking at Aspartic Proteinase Structures: A Comparison of Pepsin Structure to Other Aspartic Proteinases in the Near Active Site Region.- 4. Rearranging Pepsinogen and Pepsin by Protein Engineering.- 5. Comparative Investigations on Pig Gastric Proteases and Their Zymogens.- 6. Non-Mammalian Vertebrate Pepsinogens and Pepsins: Isolation and Characterization.- 7. Transcription Regulation of Human and Porcine Pepsinogen A.- Gastric Aspartic Proteinases: Poster Reports.- 8. A Comparative Study on Amino Acid Sequences of Three Major Isoforms of Human Pepsin A.- 9. Molecular Mass Determination by Electrospray Mass Spectrometry of Human Pepsins, Gastricsin, and Porcine Pepsin A Variants.- 10. Evidence for Electrostatic Interactions in the S2 Subsite of Porcine Pepsin.- 11. Protein Engineering of Surface Loops: Preliminary X-Ray Analysis of the CHY155-165RHI Mutant.- 12. Seminal Progastricsin.- 13. Effects of Hydrocortisone on the Pepsinogen-Producing Cells in Rat Stomach Mucosa.- 14. Effects of Omeprazole, a Proton Pump Inhibitor on Pepsinogen-Producing Cells, with Special Reference to Neonatal Development.- 15. Transcription of Embryonic Chick Pepsinogen Gene Is Affected by Mesenchymal Signals through Its 5?-Flanking Region.- 16. Serum Pepsinogen Values as Possible Markers for Evaluating the Possibility of Peptic Ulcer Recurrence under H2-Blocker Half-Dose Maintenance Therapy.- 17. The Clinical Application of the Serum Pepsinogen I and II Levels as a Mass Screening Method for Gastric Cancer.- 18. A Minute Gastric Cancer Detected by a New Screening Method Using Serum Pepsinogen I and II.- 19. Two Cases of Early Colorectal Cancer Associated with Gastric Adenoma Detected by Serum Pepsinogen Screening Method.- Non-Gastric Aspartic Proteinases: Plenary Lectures.- 20. Comparisons of the Three-Dimensional Structures, Specificities and Glycosylation of Renins, Yeast Proteinase A and Cathepsin D.- 21. Discovery of Inhibitors of Human Renin with High Oral Bioavailability.- 22. Structure of Human Cathepsin D: Comparison of Inhibitor Binding and Subdomain Displacement with Other Aspartic Proteases.- 23. Cathepsin D Crystal Structures and Lysosomal Sorting.- 24. Isolation and Characterization of Human Gastric Procathepsin E and Cathepsin E.- 25. Isolation, Characterization, and Structure of Procathepsin E and Cathepsin E from the Gastric Mucosa of Guinea Pig.- 26. Cathepsin E and Cathepsin D: Biosynthesis, Processing, and Subcellular Location.- 27. Glycoproteins of the Aspartyl Proteinase Gene Family Secreted by the Developing Placenta.- 28. Structure and Possible Function of Aspartic Proteinases in Barley and Other Plants.- 29. Aspartic Proteinases (Cyprosins) from Cynara cardunculus spp. flavescens cv. Cardoon Purification, Characterisation, and Tissue-Specific Expression.- Non-Gastric Aspartic Proteinases: Poster Reports.- 30. Acid-Activation of Rat Prorenin following Non-Proteolytic Alteration.- 31. Human Procathepsin D: Three-Dimensional Model and Isolation.- 32. Identification of Five Molecular Forms of Cathepsin D in Bovine Milk.- 33. Site-Directed Mutagenesis of a Disulfide Bridge in Cathepsin D: Expression, Activation, Purification, and Characterization.- 34. Expression of Rat Cathepsin D cDNA in Saccharomyces cerevisiae: Intracellular Sorting of Cathepsin D to Yeast Vacuole.- 35. Molecular Cloning and Immunocytochemical Localization of Jasmonic Acid Inducible Cathepsin D Inhibitors from Potato.- 36. Purification and Characterization of an Acid Proteinase from Dirofilaria immitis Worms.- 37. Inhibition and Entrapment of Aspartic Proteinases by ?2-Macroglobulin.- 38. Recombinant Human Cathepsin E.- 39. Expression of Human Cathepsin E in Methylotrophic Yeast, Pichia pastoris.- 40. Purification and Characterization of Recombinant Human Cathepsin E.- 41. Comparison of Biochemical Properties of Natural and Recombinant Cathepsin E.- 42. Increased Expression and Specific Localization of Cathepsins E and D in Vulnerable Brain Regions of Aged and Postischemic Rats.- 43. Characterization of Cathepsins E and D Accumulated at Early Stages of Neuronal Damage in Hippocampal Neurons of Rats.- 44. Functional Aspects of Cathepsin E: Is It an Embryonic or Fetal Type of Aspartic Proteinase?.- 45. Tissue- and Cell-Specific Control of Guinea Pig Cathepsin E Gene Expression.- 46. Cathepsin E Is Expressed in Fetal Rat Glandular Stomach Epithelial Cells in Primary Culture in the Absence of Mesenchymes.- 47. Cathepsin E Expressed in Pancreatic Cancer.- 48. Plant Aspartic Proteinases from Cynara cardunculus spp. flavescens cv. Cardoon; Nucleotide Sequence of a cDNA Encoding Cyprosin and Its Organ-Specific Expression.- 49. Cardosin A and B, Aspartic Proteases from the Flowers of Cardoon.- Retroviral Aspartic Proteinases: Plenary Lectures.- 50. Mechanism of Autoprocessing of a Mini-Precursor of the Aspartic Protease of Human Immunodeficiency Virus Type 1.- 51. Mutants of HIV-1 Protease with Enhanced Stability to Autodegradation.- 52. Identification of Amino Acid Residues of the Retroviral Aspartic Proteinases Important for Substrate Specificity and Catalytic Efficiency.- 53. Inhibitor-Resistant Mutants of the HIV-1 Aspartic Protease.- 54. Design and Synthesis of HIV Protease Inhibitors Containing Allophenylnorstatine as a Transition-State Mimic.- 55. Breaking the Shackles of the Genetic Code: Engineering Retroviral Proteases through Total Chemical Synthesis.- Retroviral Aspartic Proteinases: Poster Reports.- 56. X-Ray Structure of a Tethered Dimer for HIV-1 Protease.- 57. Structure of HIV-1 Protease with KNI-272: A Transition State Mimetic Inhibitor Containing Allophenylnorstatine.- 58. Molecular Dynamics of HIV-1 Protease in Complex with a Difluoroketone-Containing Inhibitor: Implications for the Catalytic Mechanism.- 59. Activated Dynamics of Flap Opening in HIV-1 Protease.- 60. Computer Simulation and Analysis of the Reaction Pathway for the Decomposition of the Hydrated Peptide Bond in Aspartic Proteases.- 61. Activities of Precursor and Tethered Dimer Forms of HIV Proteinase.- 62. Site-Directed Mutagenesis of HIV-1 Protease: Generation of Mutant Proteases with Increased Stability to Autodigestion.- 63. Molecular Modeling of the Structure of FIV Protease.- 64. Processing, Purification, and Kinetic Characterization of the Gag-Pol Encoded Retroviral Proteinase of Myeloblastosis Associated Virus Expressed in E. coli.- Microbial Aspartic Proteinases: Plenary Lectures.- 65. Extracellular Aspartic Proteinases from Candida Yeasts.- 66. Tyrosine 75 on the Flap Contributes to Enhance Catalytic Efficiency of a Fungal Aspartic Proteinase, Mucor pusillus Pepsin.- 67. Aspartic Proteinases from the Human Malaria Parasite Plasmodium falciparum.- 68. Yeast and Mammalian Basic Residue-Specific Aspartic Proteases in Prohormone Conversion.- 69. Pepstatin-Insensitive Carboxyl Proteinases.- Microbial Aspartic Proteinases: Poster Reports.- 70. The Three-Dimensional X-Ray Crystal Structure of the Aspartic Proteinase Native to Trichoderma reesei Complexed with a Renin Inhibitor CP-80794.- 71. A Quantum Mechanical Model of the Hydration and Acidity of the Active Site in Aspartic Proteases.- 72. Site-Directed Mutagenesis of Rhizopuspepsin: An Analysis of Unique Specificity.- 73. Site-Directed Mutagenesis Revealed Role of Subsite Residues of Mucor pusillus Pepsin in Catalytic Function.- 74. A Novel Intracellular Acid Proteinase from the Plasmodia of a True Slime Mold, Physarum polycephalum.- 75. Characteristics of YAP3, a New Prohormone Processing Aspartic Protease from S. cerevisiae.- 76. Candida albicans Aspartic Proteinase: cDNA Cloning and Comparison among Strains.- 77. Molecular Cloning and Sequence Analysis of a Gene Encoding an Aspartic Proteinase from Aspergillus oryzae.- 78. Aspergillus niger var. macrosporus Proteinase B. cDNA Cloning, Expression, and Activation of the Proenzyme.- 79. Expression and Secretion of Recombinant Aspartic Proteinases by Bacillus brevis.- 80. Expression in E.coliAspergillus niger var. macrosporus Proteinase A, a Non-Pepsin Type Acid Proteinase.- 81. X-Ray Crystallographic Study of a Non-Pepsin-Type Acid Proteinase, Aspergillus niger Proteinase A.- 82. Conformation Analysis of Non-Pepsin-Type Acid Proteinase A from the Fungus Aspergillus niger by NMR.- Author Index.
Series Title: Advances in experimental medicine and biology, 362.
Responsibility: edited by Kenji Takahashi.


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