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Assessing bioavailability of drug delivery systems : mathematical modeling

Author: J M Vergnaud; Iosif-Daniel Rosca
Publisher: Boca Raton, FL : CRC/Taylor & Francis, 2005.
Edition/Format:   Print book : EnglishView all editions and formats

Exploring how to apply in vitro/in vivo correlations for controlled release dosage forms, this book elucidates this phenomena. It introduces mathematical modeling methods for calculating the profiles  Read more...


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Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: J M Vergnaud; Iosif-Daniel Rosca
ISBN: 9780849330445 0849330440
OCLC Number: 61351568
Description: 223 pages : illustrations ; 24 cm
Contents: DEFINITIONS Drugs (Active Agents) and Their Supply Forms (Dosage Forms) Biopharmaceutics and Its Goal Pharmacokinetics Pharmacodynamics Liberation of the Drug Membranes Bioavailability Absorption of the Drug in the Blood Distribution of the Drug Elimination of the Drug Therapeutic Index Determination of the Pharmaceutical Parameters INTRAVENOUS ADMINISTRATION Administration of a Single Dose Repeated Intravenous Injections (DIV) Continuous Intravenous Infusion (CIV) Repeated Dosage at Constant Flow Rate ORAL DOSAGE FORMS WITH IMMEDIATE RELEASE Single Dose Effect of the Pharmacokinetic Parameters' Values Multiple Oral Doses Area under the Curve with Oral Dosage Forms Comparison Between Oral and I.V. Drug Delivery KINETICS OF DRUG RELEASE FROM ORAL SUSTAINED DOSAGE FORMS Drug Release Controlled by Diffusion Drug Release Controlled by Erosion Comparisons and Other Kinetics of Release BIBLIOGRAPHY ON IN VITRO-IN VIVO CORRELATIONS General Survey on In Vitro-In Vivo Problems In Vitro-In Vivo Correlations for Oral Immediate-Release Dosage Forms In Vitro-In Vivo Correlations with Oral Sustained-Release Dosage Forms PLASMA DRUG LEVEL WITH ORAL DIFFUSION-CONTROLLED DOSAGE FORMS Methods of Calculation Results Obtained for a Single Dose Sustained Release with Repeated Doses Prediction of the Characteristics of the Dosage Form PLASMA DRUG LEVEL WITH EROSION-CONTROLLED DOSAGE FORMS Method of Calculation Plasma Drug Profile with a Single Dose Plasma Drug Profile with Repeated Multidoses Prediction of the Characteristics of the Dosage Forms EFFECT OF PATIENT'S NONCOMPLIANCE Limited Reliability of the Patient Noncompliance with Erosion-Controlled Dosage Forms Noncompliance with Diffusion-Controlled Dosage Forms DRUG TRANSFER IN VARIOUS TISSUES Drug Transfer into and through the Lung and Bronchial Mucus Drug Transfer into the Blister Fluid Drug Transfer into Endocarditis TRANSDERMAL THERAPEUTIC SYSTEMS General Mechanisms of Drug Delivery Overview of the Skin and Its Role Calculation of the Drug Transport Results for the Transdermal Delivery of Metropolol Effect of the Characteristics of the TTS Effect of the Parameters of the Skin
Responsibility: Jean-Maurice Vergnaud, Iosif-Daniel Rosca.
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