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Assessing bioavailability of drug delivery systems : mathematical modeling

Author: J M Vergnaud; Iosif-Daniel Rosca
Publisher: Boca Raton, FL : CRC/Taylor & Francis, 2005.
Edition/Format:   Print book : EnglishView all editions and formats

Exploring how to apply in vitro/in vivo correlations for controlled release dosage forms, this book elucidates this phenomena. It introduces mathematical modeling methods for calculating the profiles  Read more...


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Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: J M Vergnaud; Iosif-Daniel Rosca
ISBN: 9780849330445 0849330440
OCLC Number: 61351568
Description: 223 pages : illustrations ; 24 cm
Contents: DEFINITIONSDrugs (Active Agents) and Their Supply Forms (Dosage Forms)Biopharmaceutics and Its GoalPharmacokineticsPharmacodynamicsLiberation of the DrugMembranesBioavailabilityAbsorption of the Drug in the BloodDistribution of the DrugElimination of the DrugTherapeutic IndexDetermination of the Pharmaceutical ParametersINTRAVENOUS ADMINISTRATIONAdministration of a Single DoseRepeated Intravenous Injections (DIV)Continuous Intravenous Infusion (CIV)Repeated Dosage at Constant Flow RateORAL DOSAGE FORMS WITH IMMEDIATE RELEASESingle DoseEffect of the Pharmacokinetic Parameters' ValuesMultiple Oral DosesArea under the Curve with Oral Dosage FormsComparison Between Oral and I.V. Drug DeliveryKINETICS OF DRUG RELEASE FROM ORAL SUSTAINED DOSAGE FORMSDrug Release Controlled by DiffusionDrug Release Controlled by ErosionComparisons and Other Kinetics of ReleaseBIBLIOGRAPHY ON IN VITRO-IN VIVO CORRELATIONSGeneral Survey on In Vitro-In Vivo Problems In Vitro-In Vivo Correlations for Oral Immediate-Release Dosage FormsIn Vitro-In Vivo Correlations with Oral Sustained-Release Dosage FormsPLASMA DRUG LEVEL WITH ORAL DIFFUSION-CONTROLLED DOSAGE FORMSMethods of CalculationResults Obtained for a Single DoseSustained Release with Repeated DosesPrediction of the Characteristics of the Dosage FormPLASMA DRUG LEVEL WITH EROSION-CONTROLLED DOSAGE FORMSMethod of CalculationPlasma Drug Profile with a Single DosePlasma Drug Profile with Repeated MultidosesPrediction of the Characteristics of the Dosage FormsEFFECT OF PATIENT'S NONCOMPLIANCELimited Reliability of the PatientNoncompliance with Erosion-Controlled Dosage FormsNoncompliance with Diffusion-Controlled Dosage FormsDRUG TRANSFER IN VARIOUS TISSUESDrug Transfer into and through the Lung and Bronchial MucusDrug Transfer into the Blister FluidDrug Transfer into EndocarditisTRANSDERMAL THERAPEUTIC SYSTEMSGeneral Mechanisms of Drug DeliveryOverview of the Skin and Its RoleCalculation of the Drug TransportResults for the Transdermal Delivery of MetropololEffect of the Characteristics of the TTSEffect of the Parameters of the Skin
Responsibility: Jean-Maurice Vergnaud, Iosif-Daniel Rosca.
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