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Biflavanoids : chemical and pharmacological aspects

Author: Shabir Hussain Lone; Mohd Akbar Khuroo
Publisher: Amsterdam, Netherlands : Elsevier Ltd., 2016.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Biflavanoids are an important class of plant metabolites offering a range of activities, good availability and relatively low toxicity. Long thought to hold possible therapeutic potential, the recent surge in interest for natural product drug discovery has further highlighted the possibility of using them in the discovery of new drugs, and Biflavanoids: Chemical and Pharmacological Aspects provides a quick reference  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Lone, Shabir Hussain.
Biflavanoids : Chemical and Pharmacological Aspects.
London : Elsevier Science, ©2016
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Shabir Hussain Lone; Mohd Akbar Khuroo
ISBN: 9780081011904 0081011903
OCLC Number: 946997807
Description: 1 online resource : illustrations
Contents: Front Cover; Biflavanoids; Copyright Page; Contents; 1 Structural Features and Occurrence of Biflavanoids; 1.1 Introduction; 1.2 Nomenclature of Biflavanoids; 1.3 Structures of Biflavanoids; 1.4 Natural Distribution of Biflavanoids; 1.5 Conclusion; References; 2 Isolation and Identification of Biflavanoids; 2.1 Introduction; 2.2 Separation and Purification; 2.2.1 Preparative PC and TLC; 2.2.2 Column Chromatography; 2.2.3 Droplet Counter-Current Chromatography; 2.2.4 High-Pressure Liquid Chromatography; 2.3 Identification; 2.3.1 UV Spectroscopy; 2.3.2 Mass Spectrometry; 2.3.3 NMR Spectroscopy. 2.4 ConclusionReferences; 3 Synthesis of Biflavanoids; 3.1 Ullmann Coupling of Halogenated Flavones; 3.2 Synthesis of Biflavones via 1,12 Biphenyls; 3.3 Metal-Catalyzed Cross-Coupling of Flavones; 3.4 Wessely-Moser Rearrangements; 3.5 Phenol Oxidative Coupling of Flavones; 3.6 Ullmann Condensation With Flavone Salts; 3.7 Nucleophilic Substitution; 3.8 Dehydrogenation of Biflavanones Into Biflavones; 3.9 Hydrogenation of Biflavone Into Biflavanone; 3.10 Special Approaches for the Synthesis of Selective Biflavanoids; 3.10.1 Photoreductive Dimerization of Flavones. 3.10.2 Synthesis of 2,42 and 2,22 Biflavanoids Using Photoinduced Electron Transfer Reactions of Flavones With Amines3.11 Conclusion; References; 4 Biochemical Pharmacology of Biflavanoids; 4.1 General Biological Properties of Biflavanoids; 4.2 Anticancer Action of Bioflavonoids; 4.3 Antimicrobial and Antiviral Activity of Bioflavonoids; 4.4 Antiinflammatory Activity of Bioflavonoids: Cellular Mechanisms of Antiinflammatory Bioflavonoids; 4.5 Analgesic Activity of Bioflavonoids; 4.6 Antiinflammatory Activity of Synthetic Flavanoids; 4.7 Conclusion; References; Back Cover.
Responsibility: Shabir Hussain Lone, Mohd Akbar Khuroo.

Abstract:

Biflavanoids are an important class of plant metabolites offering a range of activities, good availability and relatively low toxicity. Long thought to hold possible therapeutic potential, the recent surge in interest for natural product drug discovery has further highlighted the possibility of using them in the discovery of new drugs, and Biflavanoids: Chemical and Pharmacological Aspects provides a quick reference to the area in a focused manner, to support and encourage further research. Beginning with a focus on the structural features and occurrence of biflavanoids, Chapter 1 reviews key background information including notes on nomenclature and natural distribution. Chapter 2 then goes on to discuss methods for identification and isolation, with separation and purification using various chromatography methods reviewed, followed by identification via UV spectroscopy, NRM spectroscopy and mass spectrometry. Synthesis is the focus of Chapter 3, with a broad range of synthetic methods outlined, before the book concludes in Chapter 4 by describing the biochemical pharmacology of Biflavanoids and their anticancer, antimicrobial, antiviral, anti-inflammatory and analgesic activity. With its discussion of both the underlying chemistry and biological activity of Biflavanoids, Biflavanoids: Chemical and Pharmacological Aspects is a concise guide to this important class of compounds for all those working in the fields of medicinal chemistry and natural products drug discovery.

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