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Biochemical Modulation of Anticancer Agents: Experimental and Clinical Approaches : Proceedings of the 18th Annual Detroit Cancer Symposium Detroit, Michigan, USA - June 13-14, 1986

Author: Frederick A Valeriote; Laurence H Baker
Publisher: Boston, MA : Springer US, 1986.
Series: Developments in oncology, 47.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Biochemical Modulation at the present time defines an area of study in which the intracellular metabolism of a given anti cancer agent is modulated (usually by a noncytotoxic agent or a cytotoxic agent at sufficiently low dosage to make it non cytotoxic) in order to either increase the effectiveness of the particular agent against tumor cells or decrease its cytotox icity against normal cells. The major focus of  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Frederick A Valeriote; Laurence H Baker
ISBN: 9781461323310 1461323312
OCLC Number: 852792967
Description: 1 online resource (368 pages).
Contents: 1. Biochemical Modulation of Anticancer Agents: An Overview --
2. Biochemical Loci for Modulation of 5-Fluorouracil Activity --
3. Biochemical Modulation of 5-Fluorouracil with Pyrimidines, Purines and their Nucleosides --
4. Biochemical Modulation of Pyrimidine Pools for Enhancement of Antipyrimidine Cytotoxicity --
5. Modulation of 5-Fluorouracil Cytotoxicity by Intracellular Pools of 5-Phosphoribosyl-1-Pyrophosphate (PRPP) --
6. Biochemical Rationale for Selectivity in the Modulation of Methotrexate Activity During Leucovorin Rescue or Early Nucleoside Protection --
7. Clinical Aspects of FUra Metabolism Brian Leyland-Jones and --
8. Metabolic Modulation of Ara-C --
9. Enhancement of Alkylating Agent Cytotoxicity by Radiation Sensitizers --
10. Modulation of Alkylating Agents by Radiation Sensitizers --
Clinical Aspects --
11. The Role of Cellular Glutathione in Response of Tumor Cells to Radiation and Drugs --
12. Modulation of Intracellular Levels of Glutathione --
13. Glutathione Depletion with Buthionine Sulfoximine: Potential Clinical Applications --
14. Modification of Cell Sensitivity to Anticancer Agents by Polyenes --
15. Modulation of the Efflux of Anticancer Agents --
16. Problems in the Clinical Evaluation of Biochemical Modulation Therapy.
Series Title: Developments in oncology, 47.
Other Titles: Proceedings of the 18th Annual Detroit Cancer Symposium, Detroit, Michigan, USA, June 13-14, 1986
Responsibility: edited by Frederick A. Valeriote, Laurence H. Baker.

Abstract:

Proceedings of the 18th Annual Detroit Cancer Symposium, Detroit, Michigan, USA, June 13-14, 1986  Read more...

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`As a whole this book is a useful reference in a relatively new field of cancer research that may eventually expand the scope of cancer chemotherapy.' Adverse Drug Reaction, Vol. 7, No. 1, Spring Read more...

 
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