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Biochemistry of Brain.

Author: Sudhir Kumar
Publisher: Burlington : Elsevier Science, 1980.
Edition/Format:   eBook : Document : EnglishView all editions and formats
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Kumar, Sudhir.
Biochemistry of Brain.
Burlington : Elsevier Science, ©1980
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Sudhir Kumar
ISBN: 9781483153599 1483153592
OCLC Number: 869641755
Notes: 9 hyperthyroidism vs. mania.
Biochemistry of Brain.
Description: 1 online resource (1435 pages)
Contents: Cover image; Title page; Table of Contents; Copyright; PREFACE; Chapter 1: STRUCTURE, FUNCTION AND METABOLISM OF GLYCOSPHINGOLIPIDS; Publisher Summary; INTRODUCTION; STRUCTURE AND NOMENCLATURE OF SPHINGOSINE AND RELATED BASES; CLASSIFICATION OF SPHINGOLIPIDS; CHEMICAL STRUCTURES AND OCCURRENCE; ISOLATION OF GLYCOSPHINGOLIPIDS; BIOSYNTHESIS OF GLYCOSPHINGOLIPIDS; CATABOLISM OF GLYCOSPHINGOLIPIDS; PHYSIOLOGICAL FUNCTIONS OF GLYCOSPHINGOLIPIDS; ACKNOWLEDGEMENT; Chapter 2: METABOLIC DISORDERS IN SPHINGOLIPIDOSES; Publisher Summary; INTRODUCTION. BIOCHEMICAL GENETICS OF SPHINGOLIPID STORAGE DISORDERSTAY-SACHS AND SANDHOFF'S DISEASES; FABRY'S DISEASE; METACHROMATIC LEUKODYSTROPHY (SULFATIDE LIPIDOSIS); NIEMANN-PICK DISEASE; GAUCHER'S DISEASE; ACKNOWLEDGEMENT; Chapter 3: MYELIN BASIC PROTEIN: WHAT DOES IT DO?; Abstract.; I STRUCTURE OF THE BASIC PROTEIN; II ORIENTATION OF THE BASIC PROTEIN WITHIN THE MYELIN SHEATH; III BASIC PROTEIN-LIPID INTERACTIONS; IV METHYLATION OF THE BASIC PROTEIN; V PHOSPHORYLATION AND DEPHOSPHORYLATION OF THE BASIC PROTEIN; VI PRESENCE OF TWO DIFFERENT BASIC PROTEINS IN THE CNS MYELIN OF SOME RODENTS. CONCLUDING REMARKSACKNOWLEDGEMENTS; Chapter 4: THE BIOCHEMICAL AND MORPHOLOGICAL HETEROGENEITY OF MYELIN AND MYELIN-RELATED MEMBRANES; Abstract.; INTRODUCTION; SUBFRACTIONATION OF PURIFIED MYELIN; MYELIN-RELATED MEMBRANES WHICH ARE DISCARDED DURING THE PURIFICATION OF MYELIN.; POSSIBLE MORPHOLOGICAL SIGNIFICANCE OF MYELIN SUBFRACTIONS; OLIGODENDROGLIAL DERIVED FRACTIONS AS POSSIBLE PRECURSORS OF MYELIN; MYELIN-SUBFRACTIONS IN PATHOLOGICAL STATES; CURRENT STATUS AND POSSIBLE DIRECTIONS FOR FURTHER RESEARCH; ACKNOWLEDGEMENTS; ADDENDUM; Chapter 5: FOLATE METABOLISM IN BRAIN; Publisher Summary. INTRODUCTION1 GENERAL ASPECTS OF FOLATE BIOCHEMISTRY; 2 TRANSPORT OF FOLATE INTO THE CENTRAL NERVOUS SYSTEM; 3 FOLATE AND RELATED ENZYMES IN BRAIN; 4 INBORN ERRORS OF FOLATE METABOLISM; 5 FOLATE DEFICIENCY; 6 CONVULSANT EFFECTS OF FOLATE ADMINISTRATION; ADDENDUM; Chapter 6: VITAMIN B12 AND THE NERVOUS SYSTEM; Abstract.; 1 INTRODUCTION; 2 CLINICAL SYNDROMES: FETUS, INFANCY AND CHILDHOOD; 3 CLINICAL SYNDROMES: ADULTS; 4 PREVALENCE OF NERVOUS SYSTEM INVOLVEMENT; 5 INTERMEDIARY METABOLISM; 6 CONGENITAL DISORDERS OF INTERMEDIARY METABOLISM; 7 CONCLUSIONS; ADDENDUM. Chapter 7: BRAIN BIOGENIC AMINES IN MENTAL DYSFUNCTIONS ATTRIBUTABLE TO THYROID HORMONE ABNORMALITIESPublisher Summary; 1 INTRODUCTION; 2 HORMONAL IMPACT ON BIOCHEMICAL MATURATION OF THE CENTRAL NERVOUS SYSTEM; 3 CRETINISM-PHYSICAL AND BEHAVIOURAL MANIFESTATIONS; 4 NEONATAL HYPOTHYROIDISM AND CHANGES IN CENTRAL AMINE METABOLISM; 5 THYROID HORMONES-VULNERABLE PERIODS OF BRAIN DEVELOPMENT; 6 THYROID DYSFUNCTION AND AFFECTIVE DISORDERS; 7 THYROID-IMIPRAMINE INTERACTION AND THE USE OF THYROID HORMONE IN DEPRESSIVE ILLNESS; 8 THYROTROPIN RELEASING HORMONE: AN ANTIDEPRESSANT AGENT.

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