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Biochemistry of collagens : structure, function and biomarkers

Author: Morten Karsdal
Publisher: London, United Kingdom : Academic Press, ©2016.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers provides a comprehensive introduction to collagen and structural proteins. Type I collagen is one of the most abundant molecules in the body, playing essential roles in different tissues, particularly bone and skin. A key aspect of type I collagen is its post-translational modifications which are essential for correct synthesis and  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Biochemistry of collagens.
London, United Kingdom : Academic Press, ©2016
(OCoLC)945028687
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Morten Karsdal
ISBN: 0128098996 9780128098998
OCLC Number: 955139533
Notes: Includes index.
Description: 1 online resource (274)
Contents: Chapter 1. Type I Collagen Chapter 2. Type II Collagen Chapter 3. Type III Collagen Chapter 4. Type IV Collagen Chapter 5. Type V Collagen Chapter 6. Type VI Collagen Chapter 7. Type VII Collagen Chapter 8. Type VIII Collagen Chapter 9. Type IX Collagen Chapter 10. Type X Collagen Chapter 11. Type XI Collagen Chapter 12. Type XII Collagen Chapter 13. Type XIII Collagen Chapter 14. Type XIV Collagen Chapter 15. Type XV Collagen Chapter 16. Type XVI Collagen Chapter 17. Type XVII Collagen Chapter 18. Type XVIII Collagen Chapter 19. Type XIX Collagen Chapter 20. Type XX Collagen Chapter 21. Type XXI Collagen Chapter 22. Type XXII Collagen Chapter 23. Type XXIII Collagen Chapter 24. Type XXIV Collagen Chapter 25. Type XXV Collagen Chapter 26. Type XXVI Collagen Chapter 27. Type XXVII Collagen Chapter 28. Type XXVIII Collagen Chapter 29. Laminins Chapter 30. Elastin Chapter 31. Structural Biomarkers
Responsibility: edited by Morten A. Karsdal ; co-editors: Diana J. Leeming, Kim Henriksen, Anne-Christine Bay-Jensen.

Abstract:

Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers provides a comprehensive introduction to collagen and structural proteins. Type I collagen is one of the most abundant molecules in the body, playing essential roles in different tissues, particularly bone and skin. A key aspect of type I collagen is its post-translational modifications which are essential for correct synthesis and structural integrity of collagens, for tissue-specific functionality, as well as for application as biomarkers of different pathologies. This volume summarizes current data on key structural proteins (collagens, laminins and elastin), reviews how these molecules affect pathologies, and describes selected modifications of proteins that result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the ECM harbor cryptic signaling functions that may be viewed as endocrine functions. Additionally, it highlights how this knowledge can be exploited to modulate fibrotic disease.

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