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Biocombinatorial approaches for drug finding

Author: W Wohlleben; T Spellig; B Müller-Tiemann
Publisher: Berlin ; New York : Springer, ©2005.
Series: Ernst Schering Research Foundation workshop, 51.
Edition/Format:   eBook : Document : Conference publication : EnglishView all editions and formats
Summary:
Genome- and proteome-based research is generating a significant increase in the number of available drug targets. Correspondingly there is an increasing need for novel, diverse compounds, particularly based on natural compounds, as screening resource. The purpose of the Ernst Schering Research Foundation Workshop 51 was to provide a forum for an open exchange on perspectives and limitations of biocombinatorial  Read more...
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Genre/Form: Electronic books
Conference papers and proceedings
Congresses
Congrès
Additional Physical Format: Print version:
Biocombinatorial approaches for drug finding.
Berlin ; New York : Springer, ©2005
(OCoLC)57222109
Material Type: Conference publication, Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: W Wohlleben; T Spellig; B Müller-Tiemann
ISBN: 3540220925 9783540220923 9783540270553 3540270558
OCLC Number: 152577945
Description: 1 online resource (xviii, 284 pages) : illustrations (some color).
Contents: Protein Domain Fold Similarity and Natural Product Structure as Guiding Principles for Compound Library Design --
Sources of Polyketides and Non-Ribosomal Peptides --
Polyketide Synthases: Mechanisms and Models --
Functional and Structural Basis for Targeted Modification of Non-Ribosomal Peptlde Synthetases --
Prerequisites for Combinatorial Biosynthesis: Evolution of Hybrid NRPS/PKS Gene Clusters --
Engineering Glycosylation in Bioactive Compounds by Combinatorial Biosynthesis --
Glycosyltransferases and Other Tailoring Enzymes as Tools for the Generation of Novel Compounds --
Enzymatic Incorporation of Halogen Atoms into Natural Compounds --
From Glucose to Antibiotics: What Controls the Fluxes? --
Precursor-Directed Biosynthesis for the Generation of Novel Glycopetides --
Tool-Box: Tailoring Enzymes for Bio-Combinatorial Lead Development and as Markers for Genome-Based Natural Product Lead Discovery --
Natural Product Biosynthetic Assembly Lines: Prospects and Challenges for Reprogramming.
Series Title: Ernst Schering Research Foundation workshop, 51.
Responsibility: W. Wohlleben, T. Spellig, B. Müller-Tiemann, editors.
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Abstract:

Genome- and proteome-based research is generating a significant increase in the number of available drug targets. Correspondingly there is an increasing need for novel, diverse compounds,  Read more...

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