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Biological DNA sensor : the impact of nucleic acids on diseases and vaccinology

Author: Ken J Ishii; Choon Kit Tang
Publisher: Amsterdam : Elsevier/Academic Press, [2014]
Edition/Format:   Print book : EnglishView all editions and formats
Database:WorldCat
Summary:

Defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease  Read more...

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Document Type: Book
All Authors / Contributors: Ken J Ishii; Choon Kit Tang
ISBN: 9780124047327 0124047327
OCLC Number: 854749418
Description: xvi, 352 pages : illustrations ; 24 cm
Contents: Route to discovering the immunogenic properties of DNA from TLR9 to cytosolic DNA sensors / Choon Kit Tang, Cevayir Coban, Shizuo Akira and Ken J. Ishii --
The PYHIN family of molecules and their functions sensing dsDNA / Sivapriya Kailasan Vanaja, Vijay A.K. Rathinam and Katherine A. Fitzgerald --
Cytosolic DNA-sensing and the STING pathway / Glen N. Barber --
Regulation of intracellular dsDNA-induced innate immune responses by autophagy-related proteins / Tatsuya Saitoh --
Host DNA induced inflammation and autoimmune diseases 103 / Surya Pandey and Taro Kawai --
Toll-like receptor 9 and toll-like receptor 7 in the development and regulation of systemic autoimmune disease / Ann Marshak-Rothstein and Michael P. Cancro --
Bacterial infections and the DNA sensing pathway / Jan Naujoks and Bastian Opitz --
Viral infections and the DNA sensing pathway: lessons from herpesviruses and beyond / Søren R. Paludan and Andrew G. Bowie --
Cancer pathogenesis and DNA sensing / Y.J. Shen, A.R. Lam, S.S.W. Ho, C.X. Koo, N. Le Bert and S. Gasser --
DNA damage responses in atherosclerosis / Kenichi Shimada, Timothy R. Crother and Moshe Arditi --
DNA vaccine: does it target the double stranded-DNA sensing pathway? / Cevayir Coban, Miyuki Tozuka, Nao Jounai, Kouji Kobiyama, Fumihiko Takeshita, Choon Kit Tang and Ken J. Ishii --
Adjuvants targeting the DNA sensing pathways - alum based adjuvants / Christophe J. Desmet --
Adjuvants targeting the DNA sensing pathways - cyclic-di-GMP and other cyclic-dinucleotides / Rebecca Schmidt and Laurel L. Lenz.
Responsibility: [edited by] Ken J. Ishii, Choon Kit Tang.
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"The overall themes are the discovery of double-stranded DNA immunogenicity and the definition of DNA sensing pathways, double-stranded DNA and its part in modulating human diseases, and the DNA Read more...

 
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