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| Material Type: | Internet resource |
|---|---|
| Document Type: | Book, Internet Resource |
| All Authors / Contributors: |
Russell Schwartz |
| ISBN: | 9780262195843 0262195844 |
| OCLC Number: | 192050050 |
| Description: | xii, 389 p. : ill. ; 24 cm. |
| Contents: | Classic discrete optimization problems -- Hard discrete optimization problems -- Case study : sequence assembly -- General continuous optimization -- Constrained optimization -- Sampling from probability distributions -- Markov models -- Markov chain Monte Carlo sampling -- Mixing times of Markov models -- Continuous-time Markov models -- Case study : molecular evolution -- Discrete event simulation -- Numerical integration 1 : ordinary differential equations -- Numerical integration 2 : partial differential equations -- Numerical integration 3 : stochastic differential equations -- Case study : simulating cellular biochemistry -- Parameter-tuning as optimization -- Expectation maximization -- Hidden Markov models -- Linear system-solving -- Interpolation and extrapolation -- Case study : inferring gene regulatory networks -- Model validation. |
| Series Title: | Computational molecular biology series. |
| Responsibility: | Russell Schwartz. |
| More information: |
Reviews
Publisher Synopsis
"In twenty-first-century biology, modeling has a similar role as the microscope had in earlier centuries; it is arguably the most important research tool for studying complex phenomena and processes in all areas of the life sciences, from molecular biology to ecosystems analysis. Every biologist therefore needs to be familiar with the basic approaches, methods, and assumptions of modeling. Biological Modeling and Simulation is an essential guide that helps biologists explore the fundamental principles of modeling. It should be on the bookshelf of every student and active researcher." --Manfred D. Laubichler, School of Life Sciences, Arizona State University, and co-editor of Modeling Biology (MIT Press, 2007) "Russell Schwartz has produced an excellent and timely introduction to biological modeling. He has found the right balance between covering all major developments of this recently accelerating research field and still keeping the focus and level of the book at a level that is appropriate for all newcomers." --Zoltan Szallasi, Children's Hospital, Boston Read more...
