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Biology of Cellular Transducing Signals

Author: Jack Y Vanderhoek
Publisher: Boston, MA : Springer US, 1990.
Series: GWUMC Department of Biochemistry annual spring symposia.
Edition/Format:   eBook : Bibliographic data : EnglishView all editions and formats
Summary:
Intercellular communication in multicellular organisms enables cells to respond to environmental changes. Intercellular signal transduction transmitters include hormones, peptide growth factors, neurotransmitters as well as some lipid-soluble mediators. Once signalling molecules are bound to their cell surface receptors, one or more intracellular signals are generated which alter the Qehavior of the target cell. The  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Printed edition:
Material Type: Bibliographic data, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Jack Y Vanderhoek
ISBN: 9781461305590 1461305594 9781461278665 146127866X
OCLC Number: 840281002
Description: 1 online resource (428 pages).
Contents: I — Receptors --
1. Real—Time Analysis of Macromolecular Assembly During Cell Activation --
2. Identification of Residues Essential for the Active Conformation of the ?-Adrenergic Receptor by Site—Directed Mutagenesis --
3. Mechanisms for Diversification of Responses of Human Polymorphonuclear Leukocytes to Leukotrienes --
4. The Role of Covalent and Non—covalent Mechanisms in Insulin Receptor Action --
5. EGF Triggers A Similar Signalling Cascade in Different Cell Types Overexpressing the EGF Receptor --
6. Second Messenger Receptors in the Phosphoinositide Cycle --
7. Mechanisms of Receptor Regulation for the Phosphoinositide Signalling System --
8. Computer Simulation of Prostaglandin—Regulated Cyclic AMP Metabolism in Platelets: Activation and Desensitization of Adenylate Cyclase Appear to be Mediated Through Separate Prostaglandin Receptors Coupled to Gs and Gi --
II — G Proteins --
9. The Family of G Proteins --
10. Roles of G Protein Subunits in Coupling of Receptors to Ionic Channels and Other Effector Systems --
11. Receptor—Mediated Alterations of Calcium Channel Function in the Regulation of Neurosecretion --
12. Antibodies as Probes of G—Protein Structure and Function --
13. Transducin: A Model of Biological Coupling Enzymes --
14. Co—Localization by Immunofluorescence of the ? subunit(s) of Gi with Cytoplasmic Structures --
15. “Cross-Talk” and the Regulation of Hepatocyte Adenylate Cyclase Activity: Desensitization, Gi and Cyclic AMP Phosphodiesterase Regulation --
16. Activation of Human Neutrophils by Granulocyte—Macrophage Colony—Stimulating Factor: Role of Guanine—Nucleotide Binding Proteins --
17. Cytoskeletal Participation in the Signal Transduction Process: Tubulin G Protein Interactions in the Regulation of Adenylate Cyclase --
18. Initiation and Modulation of Signal Output from the T cell Antigen Receptor --
19. Selective Phosphorylation of a G Protein within Permeabilized and Intact Platelets Caused by Activators of Protein Kinase C --
20. G Proteins and Toxin-Catalyzed ADP-Ribosylation --
21. Novel Endogenous ADP—Ribosylations of Proteins in Transformed Cells: Effects of Cellular Transformation and Differentiation --
III — Inositol Phosphates --
22. Inositol 1,4,5—Trisphosphate and Inositol 1,3,4,5—Tetrakisphosphate: Two Second Messengers in a Duet of Calcium Regulation --
23. The Role of Endogenously Stimulated Protein Kinase C in Regulating Inositol Polyphosphate Accumulation in Human Platelets --
24. Leukotriene D4 Increases the Metabolism of an Inositol Tetrakisphosphate-Containing Phospholipid in U937 Cells --
IV — Kinases --
25. Immunocytochemical Localization of Protein Kinase C --
26. A Protein Kinase C Pseudosubstrate Peptide Blocks G—Protein and Mitogenic Lectin Induced Phosphorylation of the CD3 Antigen in Human T—Lymphocytes --
27. Growth Factor—Stimulated Tyrosine Phosphorylation of Phospholipase C --
V — Phospholipases --
28. Eicosanoid Formation and Regulation of Phospholipase A2 --
29. Inhibition of Phospholipase A2 Activation in P388D1 Macrophage—like Cells --
30. The Role of GTP—Binding Proteins in the Regulation of Phospholipase A2 and C in Bovine Retinal Rod Outer Segments --
31. Stimulus—Coupled Activation of Phospholipase D --
VI — Calcium --
32. The Orchestration of Stimulatory Signals for Secretion in Rat Basophilic Leukemia (RBL-2H3) Cells --
33. Synchronized Ca2+ Transients induced by Glucagon in Fura2 Loaded Hepatocytes --
34. Calcium Mobilization Mechanisms in Bovine Chromaffin Cells by Vasoactive Peptides: Angiotensin, Bradykinin and Endothelin --
35. Influence of GDP(B)S on Agonist—Induced Calcium Mobilization and Platelet Function --
VII — Eicosanoids --
36. Regulation of the Production of Lipoxygenase Products and the Role of Eicosanoids in Signal Transduction --
37. Eicosanoid Synthesis in Resident Macrophages: Role of Protein Kinase C --
38. Modulation of the S—K+ Channel of Aplysia Sensory Neurons by Lipoxygenase Metabolites of Arachidonic Acid and cAMP --
39. Inhibition of Leukotriene D4 Mediated Release of Prostacyclin Using Antisense DNA --
VIII --
Glycosylated Phosphoinositides --
40. Second Messengers of Insulin Action --
41. Control by TSH of the Production by Thyroid Cells of an Inositol Phosphateglycan, Putative Mediator of the cAMP—Independent Effects in the Gland.
Series Title: GWUMC Department of Biochemistry annual spring symposia.
Other Titles: Proceedings of the Ninth International Washington Spring Symposium at the George Washington University, held in Washington, D.C., May 8-12, 1989
Responsibility: edited by Jack Y. Vanderhoek.

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Proceedings of the Ninth International Washington Spring Symposium at the George Washington University, held in Washington, D.C., May 8-12, 1989  Read more...

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