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Biology of Cellular Transducing Signals

Author: Jack Y Vanderhoek
Publisher: Boston, MA : Springer US, 1990.
Series: GWUMC Department of Biochemistry annual spring symposia.
Edition/Format:   eBook : Bibliographic data : EnglishView all editions and formats

Proceedings of the Ninth International Washington Spring Symposium at the George Washington University, held in Washington, D.C., May 8-12, 1989


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Genre/Form: Electronic books
Additional Physical Format: Printed edition:
Material Type: Bibliographic data, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Jack Y Vanderhoek
ISBN: 9781461305590 1461305594 9781461278665 146127866X
OCLC Number: 840281002
Description: 1 online resource (428 pages).
Contents: I - Receptors.- 1. Real-Time Analysis of Macromolecular Assembly During Cell Activation.- 2. Identification of Residues Essential for the Active Conformation of the ?-Adrenergic Receptor by Site-Directed Mutagenesis.- 3. Mechanisms for Diversification of Responses of Human Polymorphonuclear Leukocytes to Leukotrienes.- 4. The Role of Covalent and Non-covalent Mechanisms in Insulin Receptor Action.- 5. EGF Triggers A Similar Signalling Cascade in Different Cell Types Overexpressing the EGF Receptor.- 6. Second Messenger Receptors in the Phosphoinositide Cycle.- 7. Mechanisms of Receptor Regulation for the Phosphoinositide Signalling System.- 8. Computer Simulation of Prostaglandin-Regulated Cyclic AMP Metabolism in Platelets: Activation and Desensitization of Adenylate Cyclase Appear to be Mediated Through Separate Prostaglandin Receptors Coupled to Gs and Gi.- II - G Proteins.- 9. The Family of G Proteins.- 10. Roles of G Protein Subunits in Coupling of Receptors to Ionic Channels and Other Effector Systems.- 11. Receptor-Mediated Alterations of Calcium Channel Function in the Regulation of Neurosecretion.- 12. Antibodies as Probes of G-Protein Structure and Function.- 13. Transducin: A Model of Biological Coupling Enzymes.- 14. Co-Localization by Immunofluorescence of the ? subunit(s) of Gi with Cytoplasmic Structures.- 15. "Cross-Talk" and the Regulation of Hepatocyte Adenylate Cyclase Activity: Desensitization, Gi and Cyclic AMP Phosphodiesterase Regulation.- 16. Activation of Human Neutrophils by Granulocyte-Macrophage Colony-Stimulating Factor: Role of Guanine-Nucleotide Binding Proteins.- 17. Cytoskeletal Participation in the Signal Transduction Process: Tubulin G Protein Interactions in the Regulation of Adenylate Cyclase.- 18. Initiation and Modulation of Signal Output from the T cell Antigen Receptor.- 19. Selective Phosphorylation of a G Protein within Permeabilized and Intact Platelets Caused by Activators of Protein Kinase C.- 20. G Proteins and Toxin-Catalyzed ADP-Ribosylation.- 21. Novel Endogenous ADP-Ribosylations of Proteins in Transformed Cells: Effects of Cellular Transformation and Differentiation.- III - Inositol Phosphates.- 22. Inositol 1,4,5-Trisphosphate and Inositol 1,3,4,5-Tetrakisphosphate: Two Second Messengers in a Duet of Calcium Regulation.- 23. The Role of Endogenously Stimulated Protein Kinase C in Regulating Inositol Polyphosphate Accumulation in Human Platelets.- 24. Leukotriene D4 Increases the Metabolism of an Inositol Tetrakisphosphate-Containing Phospholipid in U937 Cells.- IV - Kinases.- 25. Immunocytochemical Localization of Protein Kinase C.- 26. A Protein Kinase C Pseudosubstrate Peptide Blocks G-Protein and Mitogenic Lectin Induced Phosphorylation of the CD3 Antigen in Human T-Lymphocytes.- 27. Growth Factor-Stimulated Tyrosine Phosphorylation of Phospholipase C.- V - Phospholipases.- 28. Eicosanoid Formation and Regulation of Phospholipase A2.- 29. Inhibition of Phospholipase A2 Activation in P388D1 Macrophage-like Cells.- 30. The Role of GTP-Binding Proteins in the Regulation of Phospholipase A2 and C in Bovine Retinal Rod Outer Segments.- 31. Stimulus-Coupled Activation of Phospholipase D.- VI - Calcium.- 32. The Orchestration of Stimulatory Signals for Secretion in Rat Basophilic Leukemia (RBL-2H3) Cells.- 33. Synchronized Ca2+ Transients induced by Glucagon in Fura2 Loaded Hepatocytes.- 34. Calcium Mobilization Mechanisms in Bovine Chromaffin Cells by Vasoactive Peptides: Angiotensin, Bradykinin and Endothelin.- 35. Influence of GDP(B)S on Agonist-Induced Calcium Mobilization and Platelet Function.- VII - Eicosanoids.- 36. Regulation of the Production of Lipoxygenase Products and the Role of Eicosanoids in Signal Transduction.- 37. Eicosanoid Synthesis in Resident Macrophages: Role of Protein Kinase C.- 38. Modulation of the S-K+ Channel of Aplysia Sensory Neurons by Lipoxygenase Metabolites of Arachidonic Acid and cAMP.- 39. Inhibition of Leukotriene D4 Mediated Release of Prostacyclin Using Antisense DNA.- VIII -- Glycosylated Phosphoinositides.- 40. Second Messengers of Insulin Action.- 41. Control by TSH of the Production by Thyroid Cells of an Inositol Phosphateglycan, Putative Mediator of the cAMP-Independent Effects in the Gland.
Series Title: GWUMC Department of Biochemistry annual spring symposia.
Other Titles: Proceedings of the Ninth International Washington Spring Symposium at the George Washington University, held in Washington, D.C., May 8-12, 1989
Responsibility: edited by Jack Y. Vanderhoek.


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