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Biology of IGF-1 : its interaction with insulin in health and malignant states

Author: Gregory Bock; Jamie Goode
Publisher: The Atrium, Southern Gate, Chichester, UK ; Hoboken, NJ : John Wiley & Sons, ©2004.
Series: Novartis Foundation symposium, 262.
Edition/Format:   eBook : Document : Conference publication : EnglishView all editions and formats
Database:WorldCat
Summary:
"The clinical use of long-term growth hormone treatment is increasing and such treatment leads to raised IGF-1 levels. Increased insulin levels are also more common as the prevalence of insulin resistance, which frequently presages obesity and/or type 2 diabetes, increases in the population. Therefore, a careful discussion of the role of IGF-1 and insulin in various cancers is urgently needed. This book examines  Read more...
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Genre/Form: Congresses
Electronic books
Congrès
Additional Physical Format: Print version:
Symposium on Biology of IGF-1 (2003 : Novartis Foundation).
Biology of IGF-1.
The Atrium, Southern Gate, Chichester, UK ; Hoboken, NJ : John Wiley & Sons, ©2004
(DLC) 2004048819
(OCoLC)55877555
Material Type: Conference publication, Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Gregory Bock; Jamie Goode
ISBN: 0470869976 9780470869970
OCLC Number: 609346133
Reproduction Notes: Electronic reproduction. [S.l.] : HathiTrust Digital Library, 2010. MiAaHDL
Description: 1 online resource (viii, 280 pages) : illustrations.
Details: Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.
Contents: Circulating IGF-I and its role in cancer: lessons from the IGF-1 gene-deletion (LID) mouse --
Physiology of the IGF system --
Molecular basis of insulin action --
IGF-1 and insulin as growth hormones --
Insulin-like growth factors and neoplasia --
Loss of IGF2 imprinting: mechanisms and consequences --
Insulin and IGF-1 receptor trafficking and signalling --
The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb --
Structural biology of insulin and IGF-1 receptors --
Genetic blockade of the insulin-like growth factor-I receptor for human malignancy --
IGF-1 and prostate cancer --
IGF-1 and breast cancer --
IGFBPs and cancer --
The IGF receptor as anticancer treatment target --
Nutrition, insulin, IGF-1 metabolism and cancer risk: a summary of epidemiological evidence.
Series Title: Novartis Foundation symposium, 262.
Responsibility: [edited by Gregory Bock, Jamie Goode].
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Abstract:

An invaluable book containing a series of interdisciplinary discussions between clinical and basic scientists.  Read more...

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