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Bioorganic chemistry : highlights and new aspects

Author: Ulf Diederichsen
Publisher: Weinheim ; New York : Wiley-VCH, ©1999.
Edition/Format:   Print book : EnglishView all editions and formats
Database:WorldCat
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Bioorganic chemistry unites the central questions of biochemistry, medicinal chemistry, organic chemistry, and spectroscopy. This book gives an introduction for advanced students and researchers.

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Genre/Form: Aufsatzsammlung
Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Ulf Diederichsen
ISBN: 3527296654 9783527296651
OCLC Number: 41660997
Description: xxvii, 439 pages : illustrations ; 24 cm
Contents: 1. Natural Products and Drug Research. 1.1. Structural diversity of surface lipids from spiders / Stefan Schulz. 1.2. Chemistry of marine pyrrole-imidazole alkaloids / Thomas Lindel, Holger Hoffmann and Matthias Hochgurtel. 1.3. Natural products and their role in pesticide discovery / Robert Velten, Hubert Dyker and Matthias Gehling / [and others]. 1.4. Common principles in marginolactone (macrolactone) biosynthesis / Marion Zerlin and Ralf Thiericke. 1.5. Synthesis and biological activity of leukotriene derivatives / Stefan Jaroch, Bernd Buchmann and Werner Skuballa. 1.6. Diazoketones --
versatile starting materials for the diastereoselective synthesis of [beta]-lactams / Joachim Podlech and Michael R. Linder. 1.7. Selenium compounds in chemical and biochemical oxidation reactions / Gianfranco Fragale, Sara Hauptli and Michele Leuenberger / [et al.]. 1.8. Synthetic routes to oligo-tetrahydrofurans and oligo-pyrrolidines / Ulrich Koert. 1.9. Glycosphingolipids of myelin: Potential target antigens of demyclinating antibody activity in multiple sclerosis / Eckhard Kirschning and Rudolf Dernick. 1.10. Combinatorial chemistry for the identification of novel bioactive compounds / Andreas L. Marzinzik and Eduard R. Felder. 1.11. Supramolecular polymer chemistry based on multiple hydrogen bonding / Ronald F.M. Lange and E.W. Meijer --
2. Enzymatic Synthesis and Biotransformation. 2.1. Enzymatic C-C coupling: The development of aromatic prenylation for organic synthesis / Ludger Wessjohann, Bernd Sontag and Marco-Aurelio Dessoy. 2.2. Are there enzyme-catalyzed Diels --
Alder reactions? An investigation into the polyketide-synthase system required for the biosynthesis of cytochalasans / Alfons Hadener, Gilles Ritter and Patrick M. Schaeffer / [et al.]. 2.3. The truth about enzymatic halogenation in bacteria / Karl-Heinz van Pee. 2.4. Enzymatic Baeyer-Villiger oxidation with cyclohexanone monooxygenase: A new system of cofactor regeneration / Marina Vogel and Ulrich Schwarz-Linek. 2.5. The synthesis of optically active [2.2]paracyclophanes by biotransformations / Markus Pietzsch and Henning Hopf. 2.6. Multivariate analysis of biotransformations for a more effective strain selection (Intelligent screening) / Wolf-Rainer Abraham. 2.7. Extending the applicability of lipases and esterases for organic synthesis / Uwe T. Bornscheuer --
3. Carbohydrate Chemistry and Glycobiology. 3.1. Multivalent neoglycoconjugates for the inhibition of mannose-sensitive carbohydrate-protein interactions / Thisbe K. Lindhorst. 3.2. Octyl O- and S-glycosides related to the GPI anchor of Trypanosoma brucei as probes for in vitro galactosylation by trypanosomal [alpha]-galactosyltransferases / Thomas Ziegler, Ralf Dettmann and Michael Duszenko. 3.3. Convenient synthesis of C-branched carbohydrates from glycals / Thomas Sommermann, Michael Maurer and Torsten Linker. 3.4. Enzymatic tools for the synthesis of nucleotide (deoxy)sugars / Lothar Elling. 3.5. The enzyme dTDP-glucose-4,6-dehydratase as a tool for the synthesis of deoxy sugars / Werner Klaffke --
4. Peptide Chemistry and Applications. 4.1. [alpha], [alpha]-Disubstituted amino acids and bicyclic lactams: Potential building blocks for the synthesis of peptide mimics / Bernhard Westermann, Nicole Diedrichs and Ina Gedrath / [et al.]. 4.2. [beta]-Amino acids as building blocks for peptide modification / Norbert Sewald. 4.3. Reactions of chelated amino acid ester enolates and their application to natural product synthesis / Uli Kazmaier. 4.4. Cyclodepsipeptides: From natural product to anthelmin-tically active synthetic enniatins / Peter Jeschke, Winfried Etzel and Achim Harder / [et al.]. 4.5. Artificial biomimetic receptor molecules / Thomas Schrader, Michael Herm and Christian Kirsten. 4.6. Design and synthesis of modulators of sphingolipid biosynthesis / Christoph Arenz and Athanassios Giannis --
5. Nucleic Acid Chemistry: Mechanisms and Mimetics. 5.1. Structural alterations of the isopolar phosphonate bond in nucleotide and oligonucleotide analogs / Magdalena Endova, Sarka Kralikova and Radek Liboska / [et al.]. 5.2. DNA Repair: From model compounds to artificial enzymes / Thomas Carell, Lars Burgdorf and Jens Butenandt / [et al.]. 5.3. Alanyl-PNA: A model system for DNA using a linear peptide backbone as scaffold / Ulf Diederichsen. 5.4. New PNA buildings block for antisense research / Stephan Jordan and Christoph Schwemler. 5.5. RNAse active site model systems / Markus Kalesse and Thorsten Oost. 5.6. Studies on hairpin ribozymes / Sabine Muller --
6. Biosynthetic Pathways and Biochemistry. 6.1. Neuropeptide Y: A molecule for hunger, stress and memory / Annette G. Beck-Sickinger, Chiara Cabrele and Richard Soll. 6.2. Biosynthetic studies on deoxysugars: Implications for enzyme-mediated synthesis of deoxyoligosaccharides / Andreas Kirschning, Carsten Oelkers and Monika Ries / [et al.]. 6.3. Investigations on the biosynthesis of landomycin A / Sven-Eric Wohlert, Andreas Bechthold and Claus Beninga / [et al.]. 6.4. Oligosacharide antibiotics: Perspective for combinatorial biosynthesis / Andreas Bechthold and Jurgen Rohr. 6.5. Biosynthesis of plant xanthones / Ludger Beerhues, Wagner Barillas and Stefan Peters / [et al.]. 6.6. Screening of peptide libraries for the identification of mimotopes which crossreact with antibody epitopes / Christoph Seidel, Michael Grol and Hans-Georg Batz / [et al.]. 6.7. Probes for DNA base flipping by DNA methyltransferases / Birgit Holz and Elmar Weinhold. 6.8. Manipulating intracellular signal transduction / Carsten Schultz, Andrew Schnaars and Marco T. Rudolf --
7. Physical and Analytical Methods. 7.1. Adventures with atomic force microscopy / Chris Abell, Rachel McKendry and Trevor Rayment. 7.2. Marine natural products: New ways in the constitutional assignment / Matthias Kock and Jochen Junker. 7.3. Structural studies of intermolecular interactions by NMR spectroscopy / Gerd Gemmecker. 7.4. Tailor-made experimental building blocks for NMR studies of bioorganic compounds / Steffen J. Glaser. 7.5. NMR Techniques for the investigation of carbohydrate-protein interactions / Thomas Weimar. 7.6. Access to structural diversity via chemical screening / Susanne Grabley and Ralf Thiericke. 7.7. Carbohydrate --
protein interaction studies by various NMR methods and computational calculations / Hans-Christian Siebert.
Responsibility: edited by Ulf Diederichsen [and others].
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Rezensionen: ..."bietet dieses Buch einen guten \berblick und Einstieg sowohl von chemischer als auch von biologischer Seite...F]r alle, die Interesse an spannenden neuen Themen wie enzymatische Read more...

 
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