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Biopharmaceutics modeling and simulations : theory, practice, methods, and applications

Author: Kiyohiko Sugano
Publisher: Hoboken, N.J. : John Wiley & Sons, ©2013.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
BA comprehensive introduction to using modeling and simulation programs in drug discovery and development/b/ Biopharmaceutical modeling has become integral to the design and development of new drugs. Influencing key aspects of the development process, including drug substance design, formulation design, and toxicological exposure assessment, biopharmaceutical modeling is now seen as the linchpin to a drug's future  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Sugano, Kiyohiko.
Biopharmaceutics modeling and simulations.
Hoboken, N.J. : John Wiley & Sons, ©2013
(DLC) 2012007296
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Kiyohiko Sugano
ISBN: 9781118354315 1118354311 9781118354322 111835432X 9781118354308 1118354303 9781118354339 1118354338
OCLC Number: 778314813
Description: 1 online resource.
Contents: Introduction --
Theoretical framework I : solubility --
Theoretical framework II : dissolution --
Theoretical framework III : biological membrane permeation --
Theoretical framework IV : gastrointestinal transit models and integration --
Physiology of gastrointestinal tract and other administration sites in humans and animals --
Drug parameters --
Validation of mechanistic models --
Bioequivalence and biopharmaceutical classification system --
Dose and particle size dependency --
Enabling formulations --
Food effect --
Biopharmaceutical modeling for miscellaneous cases --
Intestinal transporters --
Strategy in drug discovery and development --
Epistemology of biopharmaceutical modeling and good simulation practice.
Responsibility: Kiyohiko Sugano.

Abstract:

This book provides pharmaceutical professionals with essential tools for modeling biopharmaceutics. The author uses illustrations and practical problems rather than heavy math to explain the basics  Read more...

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This book serves as an invaluable source of information for the formulation scientist, the preclinical, translational or clinical pharmacokineticist, as well as the modeling and simulation scientist. Read more...

 
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