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Biophysical approaches determining ligand binding to biomolecular targets

Author: A D Podjarny; Annick P Dejaegere; Bruno Kieffer
Publisher: Cambridge : Royal Society of Chemistry, 2010.
Series: RSC biomolecular sciences.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
The binding of small ligands to biological molecules is central to most aspects of biological function. The past twenty years has seen the development of an increasing armoury of biophysical methods that not only detect such binding, but also provide varying degrees of information about the kinetics, thermodynamics and structural aspects of the process. These methods have received increasing attention with the  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Biophysical approaches determining ligand binding to biomolecular targets.
Cambridge : Royal Society of Chemistry, 2010
(OCoLC)495938622
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: A D Podjarny; Annick P Dejaegere; Bruno Kieffer
ISBN: 9781849732666 1849732663 9781849730099 1849730091
OCLC Number: 725827817
Description: 1 online resource.
Contents: Introduction: The who, where, why questions; NMT; X-ray; Surface plasmon resonance Flourescence; Electropspray ionization mass spectrometry; Synchrotron circular dicroism; Thermal denaturation in presence of a fluorescent dye; Calorimetry; Molecular modelling Examples of the simultaneous use of several techniques to determine ligand binding
Series Title: RSC biomolecular sciences.
Responsibility: editors, Alberto Podjarny, Annick P. Dejaegere and Bruno Kieffer.

Abstract:

This book provides a complete overview of current techniques to identify ligands, characterise their binding sites and understand binding mechanisms. Suitable for biomolecular scientists at graduate  Read more...

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