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Biotransformation and metabolite elucidation of xenobiotics

Author: Ala F Nassar; Wiley InterScience (Online service)
Publisher: Hoboken, N.J. : John Wiley & Sons, ©2010.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
The goal of this book is to improve the readers' knowledge of metabolite elucidation in drug metabolism by exposing them to in depth coverage of the biotransformation of xenobiotics, strategies for identifying and characterizing metabolites, FDA guidelines, and case studies on how to improve the decision-making process in structural modification of drug candidates to reduce toxicity. The book consists of 8 chapters;  Read more...
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Genre/Form: Electronic books
Identification guides
Additional Physical Format: Print version:
Biotransformation and metabolite elucidation of xenobiotics.
Hoboken, N.J. : John Wiley & Sons, ©2010
(DLC) 2010016629
(OCoLC)612188534
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Ala F Nassar; Wiley InterScience (Online service)
ISBN: 9780470890387 047089038X 9780470890370 0470890371
OCLC Number: 669165475
Description: 1 online resource (xi, 328 pages)
Contents: Frontmatter --
Human Biotransformation / Andrew Parkinson, Brian W Ogilvie, Brandy L Paris, Tiffini N Hensley, Greg J Loewen --
Analytical Tools and Approaches for Metabolite Identification in Drug Metabolism / Yongmei Li --
Tools of Choice for Accelerating Metabolite Identification: Mass Spectrometry Technology Drives Metabolite Identification Studies Forward / Ala F Nassar --
Improving Drug Design: Considerations for the Structural Modification Process / Ala F Nassar --
Case Study: The Unanticipated Loss of N from Novel DNA Alkylating Agent Laromustine by Collision-Induced Dissociation: Novel Rearrangements / Ala F Nassar, Jing Du, David Roberts, Kevin Lin, Mike Belcourt, Ivan King, Tukiet T Lam --
Case Study: Identification of Metabolite/Decomposition Products of the Novel DNA Alkylating Agent Laromustine / Ala F Nassar, Jing Du, David Roberts, Kevin Lin, Mike Belcourt, Ivan King, Tukiet T Lam --
Strategies for the Detection of Reactive Intermediates in Drug Discovery and Development / Mark P Grillo --
Safety Testing of Drug Metabolites: Mist Guidance Impact on the Practice of Industrial Drug Metabolism / J Greg Slatter --
Index. Human biotransformation / Andrew Parkinson --
Analytical tools and approaches for metabolite identification in drug metabolism / Yongmei Li --
Tools of choice for accelerating metabolite identification : mass spec technology drives metabolite identification studies forward / Ala Nassar --
Improving drug design : considerations for the structural modification process / Ala Nassar --
Case study : the unanticipated loss of N2 from novel dna alkylating agent laromustine by collision-induced dissociation : novel rearrangements / Ala Nassar, Tukiet T. Lam --
Case study : identification of in vitro metabolite/decomposition products of the novel DNA alkylating agent laromustine / Ala Nassar, TuKiet T. Lam --
Strategies for the detection of reactive intermediates in drug discovery and development / Mark P. Grillo --
Safety testing of drug metabolites : MIST guidance impact on the practice of industrial drug metabolism / J. Greg Slatter.
Responsibility: edited by Ala F. Nassar.

Abstract:

Considerable attention has been focused recently on the potential role of human drug metabolites in drug safety and on how to provide a risk assessment for these molecules using preclinical safety  Read more...

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"The goal of this book is to improve the readers' knowledge of metabolite elucidation in drug metabolism by exposing them to in depth coverage of the biotransformation of xenobiotics, strategies for Read more...

 
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