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The brain without oxygen : causes of failure--physiological and molecular mechanisms for survival

Author: Peter L Lutz; Göran E Nilsson; Howard M Prentice
Publisher: Dordrecht ; Boston : Kluwer Academic Pub., ©2003.
Edition/Format:   Print book : English : 3rd edView all editions and formats
Summary:

The Brain Without Oxygen: Causes of failure - Physiological and molecular mechanisms for survival, Third edition, discusses the mechanisms of brain hypoxia tolerance in these exceptional vertebrates,  Read more...

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Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Peter L Lutz; Göran E Nilsson; Howard M Prentice
ISBN: 1402011652 9781402011658
OCLC Number: 51476984
Description: viii, 252 pages : illustrations ; 25 cm
Contents: Normal Brain Function --
Neuronal Communication --
Brain Energy Consumption --
Oxygen Sensing and Hypoxia Signaling --
Theories of Oxygen Sensing --
Hypoxia Signaling in the Brain --
Mechanisms of Transcriptional Activation by HIF-1 --
Hypoxia Responsive Genes and Neuroprotection --
Hypoxia Response Pathways that do not Involve HIF-1 --
Oxygen Sensing Ion Channels --
The Brain in Crisis --
Energy Failure --
Metabolic Depression, a Mechanism for Protection --
Complete Energy Failure and Anoxic Depolarization --
Neuronal Destruction --
Nitric Oxide Production --
Free Radical Formation --
Lipolysis --
Cell Swelling --
Lactate and Acidosis --
Mitochondrial Damage --
Apoptosis --
Molecular Aspects of Brain Ischemia in Mammals --
In Vivo Models of Cerebral Ischemia --
Molecular Signaling Pathways Regulating Death and Survival in Cerebral Ischemia --
Gene Activation and Transcription Factor Induction in Cerebral Ischemia --
Activation of Heat Shock Protein Genes --
Signaling Molecules in Cerebral Ischemia --
Mediators and Modulators of Apoptosis --
Brains that survive: Adaptations to Anoxia --
Phylogenetic Factors --
Transition to the Anoxic State --
The Anoxic State --
Mechanisms of Brain Anoxia Tolerance --
Energy Production --
Metabolic Depression --
Electrical Activity --
Neurotransmitters and Neuromodulators --
Ion Channels --
pH and CO[subscript 2] --
Free Radicals --
Protein Synthesis --
Brain Swelling --
Freshwater Turtles Versus Carassius --
Special Cases of enhanced Tolerance --
The Mammalian Neonate.
Responsibility: by Peter L. Lutz, Göran E. Nilsson, and Howard M. Prentice.
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