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Calmodulin antagonists and cellular physiology.

Author: Hiroyoshi Hidaka
Publisher: Oxford : Elsevier Science, 1985.
Edition/Format:   eBook : Document : EnglishView all editions and formats
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Calmodulin antagonists and cellular physiology.
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Hidaka, Hiroyoshi.
Calmodulin antagonists and cellular physiology.
Oxford : Elsevier Science, ©1985
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Hiroyoshi Hidaka
ISBN: 9780323145732 0323145736
OCLC Number: 831117148
Notes: II. Calmodulin and Calmodulin-Dependent Enzymes in Oocytes.
Description: 1 online resource (569 pages)
Contents: Front Cover; Calmodulin Antagonists and Cellular Physiology; Copyright Page; Table of Contents; Contributors; Preface; Part I: Introduction; Chapter 1. Calmodulin: An Introduction to Biochemical Aspects; I. History of Calmodulin; II. Physicochemical Properties; III. Distribution; IV. Functions of Calmodulin; V. Ca2+-Binding Properties; VI. Drug Binding to Calmodulin; References; Chapter 2. Modulation of Ca2+-Dependent Regulatory Systems by Calmodulin Antagonists and Other Agents; I. Introduction; II. The Calcium Messenger System and Specific Inhibitors. III. Calcium Channel Blockers (Calcium Antagonists)IV. Intracellular Calcium Antagonists; V. Calmodulin Antagonists; VI. Perspective; References; Part II: Mechanism of Action; Chapter 3. The Interaction of Various Drugs with Calmodulin as Monitored by 113Cd NMR; I. Introduction; II. Experimental Details; III. Binding of Cations to Calmodulin; IV. Interaction of Various Drugs with Calmodulin; V. Conclusions and Further Studies; References; Chapter 4. Calmodulin Antagonists: Structure-Activity Relationships; I. Introduction; II. Interaction of Phenothiazines with Calmodulin. III. Peptide Inhibitors of CalmodulinIV. Other Types of Calmodulin Inhibitors; V. Agents that Act at Calmodulin-Binding Sites on Calmodulin-Sensitive Enzymes; VI. Conclusions; References; Chapter 5. Structural Studies on Calmodulin and Troponin C: Phenothiazine, Peptide, and Protein Interactions with Calcium-Induced Helices; I. Introduction; II. EF Hand Structure; III. Calcium-Induced Helix; IV. Calcium-Induced Exposure of Hydrophobic Sites; V. Phenothiazine-Binding Sites and Specificity; VI. Location of Phenothiazine-Binding Sites; VII. Peptide Interactions; VIII. Protein Interactions. IX. Mechanism of Action of Troponin C and CalmodulinX. Conclusions; References; Part III: Cell Proliferation and Growth; Chapter 6. Effects of Calmodulin Antagonists on Cell Proliferation; I. Introduction; II. Effect of Calmodulin Antagonists on Growth of Cells in Culture; III. Calmodulin Levels in the Cell Division Cycle; IV. Effect of Calmodulin Levels on Actin-Containing Microfilaments; V. Conclusions; References; Chapter 7. Potential Role of Calmodulin in Tumor Promotion: Modulator of Gap Junctional Intercellular Communication; I. Initiation and Promotion Concept of Carcinogenesis. II. Potential Role of Gap Junctional Intercellular Communication in Tumor PromotionIII. Role of Calcium in the Modulation of Gap Junctional Structure and Function; IV. Role of Calmodulin in the Modulation of Gap Junctional Structure and Function; V. Summary; References; Chapter 8. Acrosome Reaction of Echinoderm Sperm; I. Introduction; II. Morphological Changes and Their Significance in Fertilization; III. Mechanism of the Acrosome Reaction; IV. The Acrosome Reaction and Calmodulin; V. Conclusion; References; Chapter 9. The Role of Calmodulin in Oocyte Maturation; I. Introduction.

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Calmodulin antagonists and cellular physiology.

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