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Camptothecins in cancer therapy

Author: Thomas G Burke, PhD.; Val R Adams
Publisher: Totowa, N.J. : Humana Press, ©2005.
Series: Cancer drug discovery and development.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:

Additional chapters describe what is known about the biochemistry, the pharmacology, and the chemistry of the camptothecins, including the mechanism of topoisomerase and how camptothecins poison this  Read more...

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Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Thomas G Burke, PhD.; Val R Adams
ISBN: 1588290271 9781588290274 1592598668 9781592598663
OCLC Number: 55633965
Description: xiii, 460 pages : illustrations (some color) ; 24 cm.
Contents: Mechanism of action of topoisomerase I poisons / Leroy F. Liu and Shyamal D. Desai --
Crystallographic insight into the mechanism of drug-induced topoisomerase I DNA damage / Alex B. Burgin, Jr., Bart L. Staker, and Lance Stewart --
Inhibitors of topoisomerase I function / Sidney M. Hecht --
Cytotoxic mechanisms of the topoisomerase I inhibitors / Yves Pommier [and others] --
Biochemical and genetic analyses of DNA topoisomerase I-mediated DNA damage / Robert C.A.M. Van Waardenburg and Mary-Ann Bjornsti --
Preclinical models for evaluating topoisomerase-I targeted drugs / Aarti S. Juvekar [and others] --
Mechanisms of resistance to camptothecins / Zeshaan A. Rasheed and Eric H. Rubin --
Recent advances in camptothecin drug design and delivery strategies / Thomas G. Burke [and others] --
Clinical experience with 9-aminocamptothecin: lessons for new drug development / Chris H. Takimoto --
Clinical studies of rubitecan (9-nitro 20(s) camptothecin) / Hilary Hewes, Judith A. Smith, and Claire Verschraegen --
Irinotecan: current clinical status and pharmacological aspects / Laurent P. Rivory --
Clinical experience with topotecan / Aimee K. Bence and Val R. Adams --
The clinical development of lurtotecan: experience with water-soluble and liposomal forms / Keith T. Flaherty [and others] --
Preclinical and clinical development of dx-8951f (exatecan mesylate): a hexacyclic camptothecin analog / Eric K. Rowinsky --
Camptothecins in the treatment of primary brain tumors / Clinton F. Stewart, Markos Leggas, and Henry S. Friedman --
Camptothecins in the treatment of lung cancer / Pankaj Kumar [and others] --
Use of camptothecins in the treatment of leukemia and related disorders / Bejamin M.F. Mow and Scott H. Kaufmann.
Series Title: Cancer drug discovery and development.
Responsibility: edited by Val R. Adams and Thomas G. Burke.
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"...an excellent all-around reference appropriate for researchers or clinicians in anticancer drug literature." - Doody's Health Science Book Review Journal

 
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