skip to content
Cancer. A Comprehensive Treatise : Volume 1. Etiology: Chemical and Physical Carcinogenesis Preview this item
ClosePreview this item
Checking...

Cancer. A Comprehensive Treatise : Volume 1. Etiology: Chemical and Physical Carcinogenesis

Author: Frederick F Becker
Publisher: Boston, MA : Springer US, 1975.
Edition/Format:   eBook : Document : English
Database:WorldCat
Rating:

(not yet rated) 0 with reviews - Be the first.

Subjects
More like this

 

Find a copy online

Links to this item

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Genre/Form: Electronic books
Additional Physical Format: Printed edition
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Frederick F Becker
ISBN: 9781461344513 1461344514 9781461344490 1461344492
OCLC Number: 852789664
Description: 1 online resource (volumes)
Contents: General Concepts.- Cytogenetics.- 1. Introduction.- 2. Human Leukemias.- 2.1. Chronic Granulocytic Leukemia and the Philadelphia-Chromosome.- 2.2. Other Myeloproliferative Disorders and "Preleukemia".- 2.3. Acute Leukemias.- 2.4. Lymphoproliferative Disorders.- 3. Human Solid Tumors.- 3.1. Malignant Tumors.- 3.2. Benign and Precancerous Lesions.- 4. Animal Tumors.- 4.1. Viral Tumors and Transformed Cells.- 4.2. Solid Tumors and Clonal Evolution.- 5. Chromosome Breakage and Cancer.- 5.1. Genetic Disorders.- 5.2. Exogeneous Agents-Radiation, Chemicals, Viruses.- 6. Conclusions and Speculations.- 7. References.- Genetics: Animal Tumors.- 1. Introduction.- 2. Speciation and Tumor Formation.- 2.1. Invertebrates.- 2.2. Vertebrates.- 3. Hybridization and Tumor Formation.- 3.1. Hybridization of Species.- 3.2. Hybridization of Strains.- 4. Inbreeding and Occurrence of Tumors.- 4.1. Development of Inbred Strains.- 4.2. Tumor Characteristics of Inbred Strains of Mice.- 4.3. Role of Inbred Strains and Their Hybrids in Cancer Research.- 5. Genetics of Spontaneous Tumors.- 5.1. The Threshold Concept in the Inheritance of Cancer.- 5.2. The Somatic Mutation Hypothesis.- 6. Genetics of Chemically Induced Tumors.- 6.1. Pulmonary Tumors in Mice.- 6.2. Subcutaneous Sarcomas in Mice.- 6.3. Selection of Appropriate Strain for Testing Carcinogens.- 7. Genetics of Hormonally Induced Tumors.- 7.1. Mammary Tumors.- 7.2. Hypophyseal Tumors.- 7.3. Adrenocortical Tumors.- 8. Genetics of Virally Induced Tumors.- 8.1. Inheritance of Susceptibility to the Mammary Tumor Virus.- 8.2. Inheritance of Susceptibility to Leukemia.- 8.3. GeneticTransmissionof Tumor Viruses.- 9. References.- Genetic Influences in Human Tumors.- 1. Introduction.- 2. Genetic States Predisposing to Cancer.- 2.1. Chromosomal Disorders.- 2.2. Mendelian Conditions.- 3. Dominantly Inherited Tumors.- 3.1. Tumor Syndromes.- 3.2. Specific Tumors.- 4. A Mutation Model for Human Cancer.- 4.1. Initiation in Two or More Steps.- 4.2. Genetic Consequences.- 4.3. Role of Environmental Carcinogens.- 5. Conclusions.- 6. References.- Hormones as Etiological Agents in Neoplasia.- 1. General Considerations.- 1.1. Historical.- 1.2. Nomenclature and Abbreviations.- 1.3. Neoplasia: Basic Defect and Types.- 1.4. Homeostasis (Cybernetics) and Neoplasia.- 1.5. Tumorigenesis by Hormonal Derangement.- 2. The Four Levels of Communications.- 2.1. Neurohypothalamic Areas and Neoplasia.- 2.2. Cell Type of the Adenohypophysis and Their Neoplasms.- 2.3. Neoplasia in Peripheral Endocrine-Related Organs.- 3. Detection of Hormonal Activity.- 3.1. General Considerations.- 3.2. Detection and Quantitation of Hormones.- 3.3. Steroid vs. Protein Hormones: Their Receptors and Translation of their Messages.- 4. Ectopic Hormones.- 5. Sequential Events: Multiglandular Syndromes.- 5.1. Neonatal Ovariectony.- 5.2. Thyroidal Carcinogenesis.- 5.3. Multiglandular Diseases.- 6. Problems and Prospects.- 6.1. The Basic Change in Neoplasia.- 6.2. Carcinogenesis without Extrinsic Carcinogens.- 6.3. Relation of Neoplasia to Aging.- 6.4. Prospects.- 7. References.- Immunocompetence and Malignancy.- 1. Introduction.- 2. Deliberate Immunosuppression and Malignancy in Experimental Animals.- 2.1. Immunosuppression and Infection with Oncogenic Viruses.- 2.2. Effects of Immunosuppression on Oncogenesis by Chemicals.- 2.3. Effects of Immunosuppression on Development of Spontaneous Tumors.- 3. Spontaneous Immunosuppression and Malignancy in Experimental Animals.- 3.1. Congenitally Athymic (Nude) Mice.- 3.2. Immunocompetence of Animals with a High Incidence of Tumors.- 3.3. Immunosuppressionby Oncogenic Viruses.- 3.4. Immunosuppression by Carcinogenic Chemicals.- 4. Immunosuppression and Malignancy in Human Beings.- 4.1. Immunodeficiency Diseases.- 4.2. Neoplasms in Recipientsof Organ Allografts.- 5. Conclusions.- 6. References.- Pathogenesis of Plasmacytomas in Mice.- 1. Introduction.- 2. "Spontaneous" Plasmacytomas.- 2.1. Ileocecal Plasmacytomas in Mice.- 2.2. Ileocecal Immunocytomas in Rats.- 2.3. Comment.- 3. Induced Plasmacytomas in Mice.- 3.1. Plasmacytomagenic Peritoneal Granuloma Inducing Agents.- 3.2. Genetic Basis of Susceptibility.- 3.3. The Peritoneal Site.- 3.4. Role of the Oil Granuloma.- 3.5. Role of Viruses in Plasmacytoma Development.- 4. Summary.- 5. References.- Chemical Carcinogenesis.- Metabolism of Chemical Carcinogens.- 1. Cancer, a Class of Diseases Due Mainly to Environmental Factors: Synthetic or Naturally Occurring.- 2. Types of Chemical Carcinogens.- 3. Metabolism of Chemical Carcinogens.- 3.1. Direct-Acting Carcinogens.- 3.2. Procarcinogens.- 3.3. Specific Activation and Metabolic Systems.- 4. Variation in Carcinogen Metabolism.- 4.1. Species and Strain.- 4.2. Sex and Endocrine Status.- 4.3. Age.- 5. Modification of Carcinogen Metabolism.- 5.1. Diet.- 5.2. Effect of Mode and Frequency of Exposure.- 5.3. Effect of Other Agents.- 5.4. Chemical Carcinogens and Mutagens.- 6. Concluding Remarks and Prospects.- 7. References.- Chemical Carcinogenesis: Interactions of Carcinogens with Nucleic Acids.- 1. Introduction.- 2. Interaction of Chemical Carcinogens with DNA.- 2.1. Covalent Interactions.- 2.2. Noncovalent Interactions.- 2.3. Purine-N-Oxides.- 2.4. Carcinogenic Metals.- 3. Interaction of Chemical Carcinogens with Mitochondrial DNA.- 4. Interaction of Chemical Carcinogens with RNA.- 4.1. General.- 4.2. Alkylating Agents.- 4.3. Aromatic Amines and Amides.- 4.4. Polycyclic Aromatic Hydrocarbons.- 4.5. 4-Nitroquinoline-N-Oxide.- 5. Influence of Carcinogen-Nucleic Acid Interactions on the Structure, Synthesis, and Function of DNA and RNA.- 5.1. Alterations in DNA Structure.- 5.2. Alterations in the Synthesis and Function of DNA and RNA.- 6. Carcinogen-DNA Interaction and Carcinogenesis.- 6.1. Carcinogen-DNA Interaction: Quantitative Analysis.- 6.2. Carcinogen-DNA Interaction: Qualitative Analysis.- 6.3. Repair in Vivo of DNA Damage Induced by Chemical Carcinogens.- 7. Perspectives and Conclusions.- 8. References.- Some Effects of Chemical Carcinogens on Cell Organelles.- 1. Introduction.- 2. The Carcinogens.- 2.1. Aflatoxins.- 2.2 Azo Dyes.- 2.3. Ethionine.- 2.4. Nitrosamines.- 2.5. Pyrrolizidine Alkaloids.- 2.6. Thioacetamide.- 3. Organelles.- 3.1. Endoplasmic Reticulum.- 3.2. Plasma Membrane.- 3.3. Mitochondria, Lysosomes, Microbodies.- 3.4. Nucleolus.- 4. Comment.- 5. References.- Sequential Aspects of Chemical Carcinogenesis: Skin.- 1. Origin of the Concept of Sequential Stages of Skin Carcinogenesis.- 2. The Search for Other Initiators and Promoters of Skin Carcinogenesis.- 3. Quantitative Analysis of the Two-Stage Mechanism.- 4. Critique of the Two-Stage Hypothesis.- 5. Extensions of the Two-Stage System.- 6. Factors Influencing Initiation and Promotion.- 7. Promoting Action in Other Tissues.- 8. The Mechanism of the Two-Stage Process.- 9. References.- Sequential Aspects of Liver Carcinogenesis.- 1. Introduction.- 2. Attempts to Differentiate between Toxic and Premalignant Changes in Experimental Liver Carcinogenesis.- 3. Methods of Determining the Sequence of Events in Hepatocarcinogenesis.- 4. References.- Neoantigen Expression in Chemical Carcinogenesis.- 1. Introduction.- 2. Neoantigens on Chemically Induced Tumors.- 2.1. Tumor-Associated Neoantigens.- 2.2. Tumor-Associated Embryonic Antigens.- 2.3. Neoantigen Expression on Cells Transformed in Vitro by Chemical Carcinogens.- 3. Conclusions and Perspectives.- 4. References.- Physical Carcinogenesis.- Physical Carcinogenesis: Radiation-History and Sources.- 1. Introduction.- 2. Types of Radiations.- 3. Sources and Levels of Radiation in the Environment.- 4. Historical Developments in Carcinogenesis by Ionizing Radiation.- 4.1. Observations in Humans.- 4.2. Observations in Experimental Animals.- 5. Evolution of Radiation Protection Standards.- 6. References.- Biophysical Aspects of Radiation Carcinogenesis.- 1. Introduction.- 2. Interaction of Radiation and Matter.- 2.1. Mechanisms.- 2.2. Dosimetry.- 2.3. Microdosimetry.- 3. General Stochastic Considerations.- 3.1. The Linear Dose-Effect Relation at Small Doses.- 3.2. Dose-Effect Relation and the Number of Absorption Events.- 4. The Quadratic Dependence of the Cellular Effect on Specific Energy.- 4.1. Dose-Effect Relations.- 4.2. Dose-RBE Relations.- 5. Applications to Radiation Carcinogenesis.- 5.1. Mammary Neoplasms in the Sprague-Dawley Rat.- 5.2. Radiation Leukemogenesis.- 6. Appendix.- 7. References.- 8. Selected General References.- Ultraviolet Radiation: Interaction with Biological Molecules.- 1. Introduction.- 2. Effects of Ultraviolet Radiation on Biological Systems.- 3. Photochemistryof Nucleic Acids.- 4. Photochemistryof Proteins.- 5. Photoinactivation of Cells and Tissues.- 6. DNA Repair.- 7. Enzyme-Catalyzed Photoreactivation.- 8. Excision Repair.- 9. Recombination Repair.- 10. Ultraviolet Light, DNA Repair, and Carcinogenesis.- 11. References.- Radiation Carcinogenesis.- 1. Introduction.- 2. Tissue Sensitivity.- 2.1. Man.- 2.2. Experimental Animals.- 3. Dose-Response Relationships.- 3.1. Theoretical Considerations.- 3.2. Observed Dose-Response Relationships in Man.- 3.3. Observed Dose-Response Relationships in Experimental Animals.- 4. Threshold or Minimum Effective Doses.- 5. Physical Factors.- 5.1. Dose Rate.- 5.2. Radiation Quality.- 5.3. Internal Emitters vs. External Exposure.- 5.4. Total-Body Exposure vs. Partial-Body Exposure.- 6. Host Factors.- 7. Relationship to Spontaneous Incidence Rate.- 8. Effect on Longevity.- 9. Interactions with Other Agents.- 10. Mechanisms.- 11. References.- Foreign Body Induced Sarcomas.- 1. Introduction.- 2. Historical Background.- 3. Foreign Body-Associated Tumors in Man.- 4. Characteristics of Foreign Body Sarcomas.- 4.1. Histopathology.- 4.2. Ultrastructure.- 4.3. Growth Characteristics, Metastasibility, Transplantability.- 4.4. Antigenicity.- 4.5. Karyological Aberrations.- 5. Factors Determining Tumor Incidence and Latency.- 5.1. Genetic Background of Host Species.- 5.2. Genetic Background of Inbred Animal Strains.- 5.3. Influence of Sex.- 5.4. Histopathology of Foreign Body Reaction.- 5.5. Chemical and Physiochemical Properties of Foreign Bodies.- 5.6. Size and Shape of Foreign Bodies.- 5.7. Porosity of Foreign Bodies.- 5.8. Concluding Remark.- 6. Exploration of Preneoplastic Events in Foreign Body Tumorigenesis.- 6.1. Histologically Suspected Preneoplastic Foci.- 6.2. Monoclonal Origin of Preneoplastic Cells.- 6.3. Appearance Time and Location of Preneoplastic Parent Cells and Clones in Relation to Foreign Body Reaction.- 6.4. Number of Preneoplastic Parent Cells Relative to Foreign Body Surface Area.- 6.5. Evidence for the Existence of Several Classes of Preneoplastic Cells According to Inherent Neoplastic Latency.- 6.6. Cell Type of Origin and Identification of Preneoplastic Parent Cells.- 7. The Tumorigenic Process: Experimental Findings in Mice and Attempts at Interpretation.- 7.1. Acquisition of a Specific Neoplastic Potential by "Parent Cells" During Early Foreign Body Reaction.- 7.2. Neoplastic "Maturation" of Clonal Cells During the Latency Period.- 7.3. Switch to Autonomous Tumor Growth.- 8. Etiological Hypotheses of Foreign Body Tumorigenesis: A Critical Appraisal.- 8.1. Chemical Components.- 8.2. Physiochemical Surface Properties.- 8.3. Interruption of Cellular Contact or Communication.- 8.4. Tissue Anoxia and Insufficient Exchange of Metabolites.- 8.5. Virus.- 8.6. Disturbance of Cellular Growth Regulation.- 9. References.
Responsibility: edited by Frederick F. Becker.

Reviews

User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.

Similar Items

Related Subjects:(2)

Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/852789664> # Cancer. A Comprehensive Treatise : Volume 1. Etiology: Chemical and Physical Carcinogenesis
    a schema:MediaObject, schema:CreativeWork, schema:Book ;
   library:oclcnum "852789664" ;
   library:placeOfPublication <http://experiment.worldcat.org/entity/work/data/1432006055#Place/boston_ma> ; # Boston, MA
   library:placeOfPublication <http://id.loc.gov/vocabulary/countries/mau> ;
   schema:about <http://id.worldcat.org/fast/1014893> ; # Medicine
   schema:about <http://id.worldcat.org/fast/1045739> ; # Oncology
   schema:about <http://dewey.info/class/616.994/e23/> ;
   schema:bookFormat schema:EBook ;
   schema:creator <http://viaf.org/viaf/55387307> ; # Frederick F. Becker
   schema:datePublished "1975" ;
   schema:exampleOfWork <http://worldcat.org/entity/work/id/1432006055> ;
   schema:genre "Electronic books"@en ;
   schema:inLanguage "en" ;
   schema:isSimilarTo <http://worldcat.org/entity/work/data/1432006055#CreativeWork/> ;
   schema:name "Cancer. A Comprehensive Treatise : Volume 1. Etiology: Chemical and Physical Carcinogenesis"@en ;
   schema:productID "852789664" ;
   schema:publication <http://www.worldcat.org/title/-/oclc/852789664#PublicationEvent/boston_ma_springer_us_1975> ;
   schema:publisher <http://experiment.worldcat.org/entity/work/data/1432006055#Agent/springer_us> ; # Springer US
   schema:url <http://link.springer.com/openurl?genre=book&isbn=978-1-4613-4451-3> ;
   schema:url <http://link.springer.com/10.1007/978-1-4613-4449-0> ;
   schema:url <http://dx.doi.org/10.1007/978-1-4613-4449-0> ;
   schema:workExample <http://worldcat.org/isbn/9781461344490> ;
   schema:workExample <http://worldcat.org/isbn/9781461344513> ;
   wdrs:describedby <http://www.worldcat.org/title/-/oclc/852789664> ;
    .


Related Entities

<http://id.worldcat.org/fast/1014893> # Medicine
    a schema:Intangible ;
   schema:name "Medicine"@en ;
    .

<http://id.worldcat.org/fast/1045739> # Oncology
    a schema:Intangible ;
   schema:name "Oncology"@en ;
    .

<http://link.springer.com/10.1007/978-1-4613-4449-0>
   rdfs:comment "from Springer" ;
   rdfs:comment "(Unlimited Concurrent Users)" ;
    .

<http://viaf.org/viaf/55387307> # Frederick F. Becker
    a schema:Person ;
   schema:familyName "Becker" ;
   schema:givenName "Frederick F." ;
   schema:name "Frederick F. Becker" ;
    .

<http://worldcat.org/entity/work/data/1432006055#CreativeWork/>
    a schema:CreativeWork ;
   schema:description "Printed edition" ;
   schema:isSimilarTo <http://www.worldcat.org/oclc/852789664> ; # Cancer. A Comprehensive Treatise : Volume 1. Etiology: Chemical and Physical Carcinogenesis
    .

<http://worldcat.org/isbn/9781461344490>
    a schema:ProductModel ;
   schema:isbn "1461344492" ;
   schema:isbn "9781461344490" ;
    .

<http://worldcat.org/isbn/9781461344513>
    a schema:ProductModel ;
   schema:isbn "1461344514" ;
   schema:isbn "9781461344513" ;
    .

<http://www.worldcat.org/title/-/oclc/852789664>
    a genont:InformationResource, genont:ContentTypeGenericResource ;
   schema:about <http://www.worldcat.org/oclc/852789664> ; # Cancer. A Comprehensive Treatise : Volume 1. Etiology: Chemical and Physical Carcinogenesis
   schema:dateModified "2017-09-02" ;
   void:inDataset <http://purl.oclc.org/dataset/WorldCat> ;
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.