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Cardiac disease in the older diabetic: management considerations.
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Cardiac disease in the older diabetic: management considerations.

Author: TJ Regan Affiliation: Division of Cardiovascular Diseases, UMDNJ-New Jersey Medical School.
Edition/Format: Article Article : English
Publication:Geriatrics, 1989 May; 44(5): 91-4, 96
Database:From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
Summary:
A number of experimental and clinical studies have indicated that the process of aging and diabetes mellitus may result in alterations of cardiac function and composition. These appear to be independent of myocardial ischemia. Left ventricular diastolic compliance is diminished in both situations associated with interstitial collagen accumulation. There is also a reduction in the relaxation rate of the ventricle. In  Read more...
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Details

Document Type: Article
All Authors / Contributors: TJ Regan Affiliation: Division of Cardiovascular Diseases, UMDNJ-New Jersey Medical School.
ISSN:0016-867X
Language Note: English
Unique Identifier: 117120596
Awards:

Abstract:

A number of experimental and clinical studies have indicated that the process of aging and diabetes mellitus may result in alterations of cardiac function and composition. These appear to be independent of myocardial ischemia. Left ventricular diastolic compliance is diminished in both situations associated with interstitial collagen accumulation. There is also a reduction in the relaxation rate of the ventricle. In the subclinical state, the aged heart cell undergoes enlargement, but this has not been described in diabetes. In an unknown portion of patients with subclinical abnormalities, the process may advance to abnormalities of systolic function, heart failure, and arrhythmias. There is no convincing evidence that intramural small vessel disease can account for the diffuse cardiomyopathy of these two states. Management requires a particularly cautious use of cardioactive agents.

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