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CDC anthrax vaccine safety and efficacy research program : interim report

Author: Institute of Medicine (U.S.); Communicable Disease Center (U.S.)
Publisher: Washington, D.C. : National Academy Press, [2001] ©2001
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Anthrax in its inhalational form is a deadly but very rare manifestation of infection with a common organism, Bacillus anthracis. Anthrax spores are very stable, a characteristic that makes possible their delivery as a weapon of biological warfare, and examples of weapons development efforts using anthrax are well known. It is important to protect the men and women in our armed services to the greatest extent  Read more...
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Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Institute of Medicine (U.S.); Communicable Disease Center (U.S.)
OCLC Number: 961548245
Notes: "Prepublication copy; uncorrected proofs."
Description: 1 online resource (xii, 45 pages) : illustrations
Contents: ""CDC Anthrax Vaccine Safety & Efficacy Research Program""; ""Copyright""; ""Contents""; ""Preface""; ""Acknowledgments""; ""REVIEWERS""; ""Executive Summary""; ""PROJECT-SPECIFIC FINDINGS AND RECOMMENDATIONS""; ""NCID-Directed Projects in the Research Program""; ""Human Clinical Trial, or Part A""; ""Animal dose ranging and challenge studies, or Part B""; ""Assays addressing correlates of immunity, or Part C""; ""Human Leukocyte Antigen (HLA) substudy""; ""NIP-Directed Projects of the Research Program"" ""Survey of knowledge, attitudes, and beliefs of military personnel about the anthrax vaccine""""Survey of knowledge, attitudes, and beliefs of military vaccinee providers about VAERS reporting""; ""CDC proposal for use of the Short Form 36""; ""Remaining components of the research program directed by the NIP""; ""1 Introduction and Background ""; ""ANTHRAX DISEASE AND PREVENTION""; ""Anthrax Disease""; ""Anthrax Vaccine""; ""VACCINE RELATED ADVERSE EVENTS""; ""POLICY CONTEXT OF REPORT""; ""Anthrax Vaccination Policy""; ""CDC'S RESPONSE TO CONGRESS"" ""2 Interim Findings and Recommendations """"NCID RESEARCH ACTIVITIES""; ""Part A: Clinical Trial""; ""CDC proposal for use of the Short Form 36""; ""Part B: Non-human Primate Dose-Ranging and Challenge Study""; ""Part C: Assays of Immunologic Correlates of Protection""; ""NIP RESEARCH ACTIVITIES""; ""Knowledge, Attitudes, and Beliefs of Military Personnel about the Anthrax Vaccine""; ""Knowledge, Attitudes, and Beliefs of Vaccine Providers about VAERS Reporting""; ""Data Mining Using the VAERS Database""; ""Meta-Analysis of Existing Studies on the Anthrax Vaccine""; ""REFERENCES"" ""ACRONYMS""""Appendix A Study Activities ""; ""Appendix B Biographical Sketches ""
Responsibility: Institute of Medicine.

Abstract:

Anthrax in its inhalational form is a deadly but very rare manifestation of infection with a common organism, Bacillus anthracis. Anthrax spores are very stable, a characteristic that makes possible their delivery as a weapon of biological warfare, and examples of weapons development efforts using anthrax are well known. It is important to protect the men and women in our armed services to the greatest extent possible. The Department of Defense (DoD) established the Anthrax Vaccine Immunization Program (AVIP) in order to do so; however, some parties have raised questions about the safety and even the efficacy of the vaccine. As a result, the DoD is sponsoring an Institute of Medicine (IOM) study of the safety and efficacy of the vaccine, and Congress has instructed the Centers for Disease Control and Prevention (CDC) to conduct further safety and efficacy research. The CDC contracted with the IOM to review their research program for completeness and appropriateness. This document is an interim report of the Committee to Review the CDC Anthrax Vaccine Safety and Efficacy Research Program, and reflects only a preliminary review of a program still in development.

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