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Cell and Molecular Biology of Breast Cancer

Author: Heide Schatten
Publisher: Dordrecht : Springer, 2013.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
Highlighting recent advances in our understanding of breast cancer, this book is intended for a wide audience as a reference book. Included are reviews of genetics, epigenetics, various aspects of cell and molecular biology, and several other areas of breast cancer that are aimed at determining new intervention sites for treatments and cures of the disease. The chapters are written by internationally recognized  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Schatten, Heide.
Cell and Molecular Biology of Breast Cancer.
Dordrecht : Springer, ©2013
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Heide Schatten
ISBN: 9781627036344 1627036342 9781627036337 1627036334
OCLC Number: 862048921
Notes: 4.18 Targeting the Tumour Microenvironment, Clinical Implications and Perspective.
Description: 1 online resource (382 pages)
Contents: Preface; Contents; Chapter 1: Histopathology and Grading of Breast Cancer; 1.1 Introduction; 1.2 Ductal Carcinoma In Situ; 1.3 Infiltrating Ductal Carcinoma; 1.4 Infiltrating Lobular Carcinoma; 1.5 Other Histologic Types; 1.5.1 Tubular Carcinoma; 1.5.2 Mucinous (Colloid) Carcinoma; 1.5.3 Medullary Carcinoma; 1.5.4 Tubulolobular Carcinoma; 1.5.5 Micropapillary Carcinoma (Fig. 1.12); 1.5.6 Metaplastic Carcinoma; 1.5.7 Adenoid Cystic Carcinoma (Fig. 1.14); 1.6 Tests on Breast Tissue; 1.6.1 Hormone Receptors; 1.6.2 Markers of Proliferation; 1.6.3 HER2 Overexpression. 1.6.4 Multigene Predictors of Clinical Outcome1.6.5 Urokinase Plasminogen Activator System; 1.6.6 P53 Gene Analysis; 1.6.7 Other Markers of Invasion and Metastasis; 1.7 Summary; References; Chapter 2: Multicentric/Multifocal Breast Cancer: Overview, Biology, and Therapy; 2.1 Introduction; 2.2 Multifocality: What Definition?; 2.3 Multifocality and Breast Conservative Treatment; 2.4 Multifocality and Outcome; 2.5 Assessing Tumor Burden in Multiple Foci; 2.6 Tumor Burden Versus Lymphatic Metastases; 2.7 Future Perspectives: Biological Determinants of Aggressiveness; 2.8 Closing Remarks. 3.3.3 Immune-Induced EMT in Cancer Progression3.3.4 Immune-Induced EMT Can Lead to Cancer Stem Cell Phenotype; 3.4 Conclusions; References; Chapter 4: Remodelling of the Extracellular Matrix: Implications for Cancer; 4.1 What Is the Extracellular Matrix?; 4.2 Laying Down the ECM; 4.3 Functional Properties of the ECM; 4.4 The Dynamic Nature of the ECM; 4.5 Regulation of ECM Dynamics; 4.6 Posttranslational Cross-Linking of the ECM; 4.7 The Importance of Correct Cell-ECM Interactions; 4.8 Biochemical Cues; 4.9 Biomechanical Cues. 4.10 The Importance of the ECM in Development: Mammary Gland Morphogenesis4.11 ECM Dynamics in Adult Mammary Gland Tissue; 4.12 When It All Goes Wrong: The ECM and the Tumour Microenvironment; 4.13 Deregulated ECM Dynamics Play a Critical Role in Influencing the Tumour Microenvironment; 4.14 Disrupting ECM Dynamics and Turnover; 4.15 The ECM in Metastatic Dissemination and Colonisation: The Century Old Seed and Soil Hypothesis; 4.16 ECM Dynamics and the Pre-metastatic Niche; 4.17 Influence of the Tumour Microenvironment on Response to Therapy.

Abstract:

Highlighting recent advances in our understanding of breast cancer, this book is intended for a wide audience as a reference book. Included are reviews of genetics, epigenetics, various aspects of cell and molecular biology, and several other areas of breast cancer that are aimed at determining new intervention sites for treatments and cures of the disease. The chapters are written by internationally recognized experts and include reviews of key topics in breast cancer research. Each chapter highlights the new aspects of specific research topics and the various impacts of designing new strateg.

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